2021
C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters
Zhang X, Detering L, Sultan D, Heo G, Luehmann H, Taylor S, Choksi A, Rubin J, Liu Y. C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters. ACS Applied Bio Materials 2021, 5: 235-242. PMID: 35014818, DOI: 10.1021/acsabm.1c01056.Peer-Reviewed Original ResearchConceptsC-X-C chemokine receptor 4C-X-CGlioblastoma multiformePositron emission tomographyAggressive primary malignant brain cancerAssociated with poor patient survivalDifficult-to-treat cancersPET/computed tomography imagingPoor patient survivalChemokine receptor 4GBM mouse modelPositron emission tomography imagingEffective drug deliveryGBM imagingMalignant brain cancerPrimary malignant brain cancerOverall survivalMultimodal treatmentDrug deliveryPatient survivalPoor prognosisTreatment responseTargeted PET imagingRenal clearanceMouse model
2020
Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma
Zhang X, Ye D, Yang L, Yue Y, Sultan D, Pacia C, Pang H, Detering L, Heo G, Luehmann H, Choksi A, Sethi A, Limbrick D, Becher O, Tai Y, Rubin J, Chen H, Liu Y. Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma. ACS Applied Nano Materials 2020, 3: 11129-11134. PMID: 34337344, PMCID: PMC8320805, DOI: 10.1021/acsanm.0c02297.Peer-Reviewed Original ResearchDiffuse intrinsic pontine gliomaBlood-brain tumor barrierIntrinsic pontine gliomaBlood-brain barrierPositron emission tomographyPontine gliomaBrainstem malignancyDelivery of therapeuticsTumor barrierWildtype miceEffective treatmentEmission tomographyFUS treatmentTumorDelivery efficiencyMiceFUS pressureGliomaTreatmentEffective deliveryDeliveryTime-dependent diffusionPET/CTMalignancyFUS