2024
Deterministic reprogramming of neutrophils within tumors
Ng M, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo G, Yang K, Zhang Y, Jin J, Liong K, Wu D, He R, Liu D, Teh Y, Bleriot C, Caronni N, Liu Z, Duan K, Narang V, Ballesteros I, Moalli F, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y, Tey H, Chong S, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng L. Deterministic reprogramming of neutrophils within tumors. Science 2024, 383: eadf6493. PMID: 38207030, PMCID: PMC11087151, DOI: 10.1126/science.adf6493.Peer-Reviewed Original Research
2023
3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo
Klemt I, Varzatskii O, Selin R, Vakarov S, Kovalska V, Bila G, Bilyy R, Voloshin Y, Cuartero I, Hidalgo A, Frey B, Becker I, Friedrich B, Tietze R, Friedrich R, Alexiou C, Ursu E, Rotaru A, Solymosi I, Pérez-Ojeda M, Mokhir A. 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo. Journal Of The American Chemical Society 2023, 145: 22252-22264. PMID: 37773090, DOI: 10.1021/jacs.3c08827.Peer-Reviewed Original ResearchEndoplasmic reticulum stressCancer cellsDose-limiting side effectReticulum stressPrimary tumor growthSK-MES-1ER stressBone marrow cellsPromyelocytic leukemia HL-60Acute promyelocytic leukemia HL-60LLC1 cellsActive doseSide effectsER stress inducersTumor growthSuch drugsLeukemia HL-60Normal bloodProteosome inhibitorMarrow cellsT cell leukemia JurkatOvarian carcinoma A2780DrugsROS increaseNormal cells