2024
Global Disparities in the Characteristics and Outcomes of Leukemia Clinical Trials: A Cross-Sectional Study of the ClinicalTrials.gov Database.
Alhajahjeh A, Rotter L, Stempel J, Grimshaw A, Bewersdorf J, Blaha O, Kewan T, Podoltsev N, Shallis R, Mendez L, Stahl M, Zeidan A. Global Disparities in the Characteristics and Outcomes of Leukemia Clinical Trials: A Cross-Sectional Study of the ClinicalTrials.gov Database. JCO Global Oncology 2024, 10: e2400316. PMID: 39621951, DOI: 10.1200/go-24-00316.Peer-Reviewed Original ResearchEndoscopic therapy for gastrointestinal angiodysplasia
Alhamid A, Aljarad Z, Chaar A, Grimshaw A, Hanafi I. Endoscopic therapy for gastrointestinal angiodysplasia. 2024, 2024: cd014582. PMID: 39297500, PMCID: PMC11411905, DOI: 10.1002/14651858.cd014582.Peer-Reviewed Original ResearchTrustworthy and ethical AI-enabled cardiovascular care: a rapid review
Mooghali M, Stroud A, Yoo D, Barry B, Grimshaw A, Ross J, Zhu X, Miller J. Trustworthy and ethical AI-enabled cardiovascular care: a rapid review. BMC Medical Informatics And Decision Making 2024, 24: 247. PMID: 39232725, PMCID: PMC11373417, DOI: 10.1186/s12911-024-02653-6.Peer-Reviewed Original ResearchConceptsHealthcare provider perspectiveRisk of patient harmCardiovascular careProvider perspectiveAI-based medical devicesPatient harmLoss of patient autonomyLack of robust evidenceTrust barriersHealthcare inequalitiesImprove careHealthcare providersCitation chasingPerceived lack of transparencyHealthcare existPatient careEthical concernsIntegration of AIPatient autonomyPatient interestLiterature reviewPerceived lackPractice guidelinesCareStudy designDyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocol
Choy C, McAdow M, Rosenberg J, Grimshaw A, Martinez-Brockman J. Dyadic care to improve postnatal outcomes of birthing people and their infants: A scoping review protocol. PLOS ONE 2024, 19: e0298927. PMID: 38625992, PMCID: PMC11020692, DOI: 10.1371/journal.pone.0298927.Peer-Reviewed Original ResearchConceptsCare interventionsBirthing personsHealth outcomesCare studiesJoanna Briggs Institute critical appraisal toolsPostnatal health outcomesReduce healthcare disparitiesImprove healthcare deliveryProvision of careCritical appraisal toolsWHO regional databasesRisk of biasOpen Science FrameworkObstetric careHealthcare disparitiesImplementation outcomesNarrative synthesisAppraisal ToolImprove disparitiesHealthcare deliveryGrey literaturePractice gapReview protocolWeb of Science Core CollectionHealthcare systemLow skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis
Anabtawi N, Pasala M, Grimshaw A, Kharel P, Bal S, Godby K, Siwakoti A, Buford T, Bhatia S, Costa L, Williams G, Giri S. Low skeletal muscle mass and treatment outcomes among adults with haematologic malignancies: A systematic review and meta‐analysis. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1084-1093. PMID: 38558541, PMCID: PMC11154774, DOI: 10.1002/jcsm.13446.Peer-Reviewed Original ResearchConceptsLow skeletal muscle massNon-relapse mortalityProgression free survivalTreatment-related toxicityHaematological malignanciesOverall survivalSkeletal muscle massMuscle massEffects of low skeletal muscle massImpact of low skeletal muscle massIncreased risk of treatment-related toxicityPresence of low skeletal muscle massRisk of treatment-related toxicityHazard ratioAssociated with worse survival outcomesAssociated with worse OSDerSimonian-Laird random-effects modelModerate heterogeneityInferior overall survivalWorse survival outcomesConfidence intervalsRandom-effects modelFree survivalSolid malignanciesPre-published protocolDigital Health Interventions for Hypertension Management in US Populations Experiencing Health Disparities
Katz M, Mszar R, Grimshaw A, Gunderson C, Onuma O, Lu Y, Spatz E. Digital Health Interventions for Hypertension Management in US Populations Experiencing Health Disparities. JAMA Network Open 2024, 7: e2356070. PMID: 38353950, PMCID: PMC10867699, DOI: 10.1001/jamanetworkopen.2023.56070.Peer-Reviewed Original ResearchConceptsDigital health interventionsHealth disparitiesHealth interventionsSystematic reviewSystolic BPSocial determinants of healthHypertension managementCommunity health workersFactors associated with cardiovascular diseaseDeterminants of healthLeveraging digital healthRemote BP monitoringDigital health technologiesStandard care groupMeta-analysisBlood pressureDiastolic BPPreferred Reporting ItemsControl groupSystolic BP changeBaseline to 6Random-effects modelSkilled nursingCultural tailoringSocial determinants
2023
Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review.
Wang L, Grimshaw A, Mezzacappa C, Rahimi Larki N, Yang Y, Justice A. Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1490-1497. PMID: 37610426, PMCID: PMC10873036, DOI: 10.1158/1055-9965.epi-23-0468.Peer-Reviewed Original ResearchConceptsRoutine risk factorsPancreatic cancerRisk factorsPolygenic risk scoresClinical dataRisk scoreAddition of PRSClinical risk factorsRoutine clinical dataCancer risk predictionDatabase inceptionCancerClinical applicabilityRelevant exposuresGenetic riskRisk predictionCancer-specific polygenic risk scoresScoping ReviewRiskEuropean ancestryPopulation representativeScoresMost studiesAppropriate controlsFactorsEndometrial responses to bacterial and viral infection: a scoping review.
Lindsay C, Potter J, Grimshaw A, Abrahams V, Tong M. Endometrial responses to bacterial and viral infection: a scoping review. Human Reproduction Update 2023, 29: 675-693. PMID: 37290428, PMCID: PMC10477945, DOI: 10.1093/humupd/dmad013.Peer-Reviewed Original ResearchConceptsEndometrial responseViral infectionUterus/endometriumFull-text studiesInnate immune sensingInnate immune responseFree-text termsEmbase/MedlineIntrauterine infectionObstetric complicationsEndometrial productionCochrane LibraryFuture studiesImplantation failureNeisseria gonorrheaImmune cellsMost infectionsImmune responseUterine functionChlamydia trachomatisAnimal modelsImmune sensingEndometriumZika virusMajority of studiesOffspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review
Chock E, Dahal S, Grimshaw A, Suter L, Liew Z, Felson D. Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review. Seminars In Arthritis And Rheumatism 2023, 61: 152230. PMID: 37295300, PMCID: PMC10521166, DOI: 10.1016/j.semarthrit.2023.152230.Peer-Reviewed Original ResearchConceptsChronic inflammatory arthritisOffspring neurodevelopmental outcomesAntirheumatic therapyNeurodevelopmental outcomesInflammatory arthritisTumor necrosis factor-alpha inhibitorsNecrosis factor-alpha inhibitorsNonsteroidal anti-inflammatory drugsEarly first trimesterOffspring health outcomesAnti-inflammatory drugsMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsWeb of ScienceAttention deficit hyperactive disorderCorticosteroid useRheumatic diseasesFirst trimesterCochrane LibraryAlpha inhibitorsStudy qualityMedication safetyFetal wellbeingIndependent reviewersMost womenIdiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis
Rozner R, Gisriel S, Damianos J, Grimshaw A, Rizwan R, Nawaz A, Chan K, Wan D, Pantel H, Bhutta A, Fenster M, Brandt L, Barbieri A, Robert M, Feuerstadt P, Li D. Idiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis. Journal Of Gastroenterology And Hepatology 2023, 38: 1040-1046. PMID: 37086041, DOI: 10.1111/jgh.16193.Peer-Reviewed Original ResearchConceptsIdiopathic myointimal hyperplasiaColonic ischemiaMesenteric veinRectal bleedingRectal involvementMyointimal hyperplasiaSystematic reviewYounger ageMultivariate logistic regression analysisCurative surgical resectionInferior mesenteric veinPre-surgical identificationLogistic regression analysisRegression analysisIschemic colitisAbdominal painMucosal ulcerationEndoscopic findingsSelect patientsSurgical resectionUncommon causeDiagnostic delaySurgical treatmentClinical featuresHospital recordsEstimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis
Carey G, Holleck J, Alshaeba S, Jayakrishnan R, Gordon K, Grimshaw A, Gunderson C. Estimated mortality with early empirical antibiotic coverage of methicillin-resistant Staphylococcus aureus in hospitalized patients with bacterial infections: a systematic review and meta-analysis. Journal Of Antimicrobial Chemotherapy 2023, 78: 1150-1159. PMID: 36964648, DOI: 10.1093/jac/dkad078.Peer-Reviewed Original ResearchConceptsCommon infectious syndromesEmpirical antibioticsPrevalence of MRSAInfectious syndromesMRSA infectionIll patientsMortality rateSystematic reviewAbsolute mortality benefitAnti-MRSA therapyEmpirical antibiotic coverageLow-risk infectionsSoft tissue infectionsUrinary tract infectionAbsolute risk reductionMethicillin-resistant Staphylococcus aureusCatheter-related infectionsStudy of patientsBaseline mortality ratesSystematic literature searchWeb of ScienceMRSA coverageAntibiotic coverageEmpirical antimicrobialsMortality benefitBurden of bone disease in chronic pancreatitis: A systematic review and meta-analysis
Chhoda A, Hernandez-Woodbine M, Addo N, Nasir S, Grimshaw A, Gunderson C, Ahmed A, Freedman S, Sheth S. Burden of bone disease in chronic pancreatitis: A systematic review and meta-analysis. World Journal Of Gastroenterology 2023, 29: 1374-1394. PMID: 36925454, PMCID: PMC10011962, DOI: 10.3748/wjg.v29.i8.1374.Peer-Reviewed Original ResearchConceptsPrevalence of osteopeniaChronic pancreatitisFragility fracturesBone diseaseCP patientsClinical featuresPooled prevalenceSystematic reviewBaseline clinical featuresSignificant bone diseasePrevalence of osteoporosisBody mass indexCause of morbidityBone mineralization parametersRandom-effects modelPaucity of dataWeb of SciencePERT useSmoking exposureSystemic inflammationTherapy useMass indexTrue burdenCochrane LibraryMean ageOvarian absence: a systematic literature review and case series report
Chen H, Grimshaw A, Taylor-Giorlando M, Vijayakumar P, Li D, Margetts M, Pelosi E, Vash-Margita A. Ovarian absence: a systematic literature review and case series report. Journal Of Ovarian Research 2023, 16: 13. PMID: 36642704, PMCID: PMC9841619, DOI: 10.1186/s13048-022-01090-1.Peer-Reviewed Original ResearchConceptsOvarian absenceUterine abnormalitiesVascular accidentRenal abnormalitiesInfertility/subfertilityCase series reportWeb of SciencePelvic painDiagnostic laparoscopyClinical presentationVascular etiologyOvid EmbaseCochrane LibraryFrequent presentationUncommon conditionSeries reportCongenital anomaliesOvid MEDLINEOvarian abnormalitiesFertility considerationsGenitourinary anatomyExclusion criteriaEmbryological defectUnpublished casesSystematic review
2022
The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimatesRandomized Clinical Trials of Machine Learning Interventions in Health Care
Plana D, Shung DL, Grimshaw AA, Saraf A, Sung JJY, Kann BH. Randomized Clinical Trials of Machine Learning Interventions in Health Care. JAMA Network Open 2022, 5: e2233946. PMID: 36173632, PMCID: PMC9523495, DOI: 10.1001/jamanetworkopen.2022.33946.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsRisk of biasClinical trialsSystematic reviewNon-RCT designHealth careCONSORT-AIClinical adoptionCochrane riskOvid EmbaseCochrane LibraryTrial characteristicsOvid MEDLINEPrimary interventionExclusion criteriaCommon reasonMedian proportionPatient careRCT designLiterature searchOverall riskRelevant articlesLack of participantsTrialsGoogle ScholarInvestigational venetoclax combination therapy in acute myeloid leukemia – a systematic review and meta-analysis
Shimony S, Rozental A, Bewersdorf J, Goldberg A, Stein E, Grimshaw A, Stone R, DeAngelo D, Wolach O, Stahl M. Investigational venetoclax combination therapy in acute myeloid leukemia – a systematic review and meta-analysis. Haematologica 2022, 107: 2955-2960. PMID: 36453519, PMCID: PMC9713559, DOI: 10.3324/haematol.2022.281453.Peer-Reviewed Original ResearchDrug repurposing: a systematic review on root causes, barriers and facilitators
Krishnamurthy N, Grimshaw AA, Axson SA, Choe SH, Miller JE. Drug repurposing: a systematic review on root causes, barriers and facilitators. BMC Health Services Research 2022, 22: 970. PMID: 35906687, PMCID: PMC9336118, DOI: 10.1186/s12913-022-08272-z.Peer-Reviewed Original ResearchConceptsData accessIntellectual property challengesDesign decisionsCompound databasesExamples of companiesBusiness reasonsCore approachRoot causeMulti-partner collaborationsText termsFull potentialText reviewBusiness Source CompleteResourcesAccessCollaborationDatabaseSuperiorityMore informationSafety problemsThe Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review
Hanchuk S, Casilla-Lennon M, Zheng S, Kim DD, Press B, Nguyen JV, Grimshaw A, Leapman MS, Rickey LM, Cavallo JA. The Medical Community’s Evolving Focus on Physician and Surgeon Pregnancy: Thematic Trends From a Scoping Review. Academic Medicine 2022, 97: 1071-1078. PMID: 35171119, PMCID: PMC9247020, DOI: 10.1097/acm.0000000000004629.Peer-Reviewed Original ResearchConceptsPhysician pregnancyMulti-institutional prospective observational studyDefinitive evidence-based recommendationsMaternal-fetal health outcomesProspective observational studyImpact of pregnancyEvidence-based recommendationsFull-text reviewOvid EmbaseCochrane LibraryPhysician specialtyObservational studyOvid MEDLINEInclusion criteriaStudy populationPregnancyHealth outcomesPhysiciansCommunity studySurgical specialtiesGoogle ScholarWork productivityWomen physiciansScoping ReviewPublication yearShortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis
Park DY, Wang P, An S, Grimshaw AA, Frampton J, Ohman EM, Rao SV, Nanna MG. Shortening the duration of dual antiplatelet therapy after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta-analysis. American Heart Journal 2022, 251: 101-114. PMID: 35654162, PMCID: PMC10904033, DOI: 10.1016/j.ahj.2022.05.019.Peer-Reviewed Original ResearchConceptsMonths of DAPTHazard ratioIschemic eventsDuration of DAPTSelect patient characteristicsDual antiplatelet therapyAcute coronary syndromeCoronary artery lesionsPercutaneous coronary interventionConfidence intervalsAssociation of outcomesRandom-effects modelComprehensive literature searchMeta-regression analysisMajor bleedingAntiplatelet therapyCoronary syndromeArtery lesionsCoronary interventionControlled TrialsPatient characteristicsPrespecified outcomesGreater proportionSimilar efficacySystematic reviewMicroangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study
Lam R, Tarangelo N, Wang R, Horibe M, Grimshaw AA, Jain D, Haffar S, Bazerbachi F, Kunz PL, Li DK. Microangiopathic Hemolytic Anemia Is a Late and Fatal Complication of Gastric Signet Ring Cell Carcinoma: A Systematic Review and Case-Control Study. The Oncologist 2022, 27: 751-759. PMID: 35589098, PMCID: PMC9438916, DOI: 10.1093/oncolo/oyac093.Peer-Reviewed Original ResearchConceptsGastric signet ring cell carcinomaSignet ring cell carcinomaMicroangiopathic hemolytic anemiaHemolytic anemiaCell carcinomaMultivariable Cox proportional hazards regression modelingCox proportional hazards regression modelingSystematic reviewRare paraneoplastic syndromeStage-matched casesEnd Results (SEER) databaseLate-stage complicationsRisk of mortalityCase-control studyBone painParaneoplastic syndromeFatal complicationMedian survivalMetastatic diseaseOverall survivalLymph nodesIndex presentationPrognostic featuresResults databasePooled cohort