2023
Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon
Micali N, Ma S, Li M, Kim S, Mato-Blanco X, Sindhu S, Arellano J, Gao T, Shibata M, Gobeske K, Duque A, Santpere G, Sestan N, Rakic P. Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon. Science 2023, 382: eadf3786. PMID: 37824652, PMCID: PMC10705812, DOI: 10.1126/science.adf3786.Peer-Reviewed Original ResearchOrigin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original ResearchLaminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization
Junaković A, Kopić J, Duque A, Rakic P, Krsnik Ž, Kostović I. Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization. Brain Structure And Function 2023, 228: 613-633. PMID: 36592215, PMCID: PMC9944618, DOI: 10.1007/s00429-022-02606-7.Peer-Reviewed Original Research
2022
Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Rash B, Arellano J, Duque A, Rakic P. Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 120: e2210967120. PMID: 36574666, PMCID: PMC9910595, DOI: 10.1073/pnas.2210967120.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubcortical white matterCerebral cortexWhite matterFormation of gyriPrimate cerebral cortexMammalian cerebral cortexMarkers of proliferationCortical malformationsCortical plateGlial cellsGyral developmentSubventricular zoneCortical neurogenesisFetal developmentVentricular zoneCortical foldingNeuronal progenitorsGyrificationNeuronal growthNeuropil growthPrimary gyriCortexNeurodevelopmental disordersGyrus
2020
Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Datta D, Leslie SN, Morozov YM, Duque A, Rakic P, van Dyck CH, Nairn AC, Arnsten AFT. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex. Journal Of Neuroinflammation 2020, 17: 8. PMID: 31906973, PMCID: PMC6945481, DOI: 10.1186/s12974-019-1683-1.Peer-Reviewed Original ResearchConceptsRat medial PFCPrimate dlPFCC1q levelsMedial PFCLayer IIIC1q proteinPrecise anatomical distributionMacaque dorsolateral prefrontal cortexAge-related degenerationDorsolateral prefrontal cortexAge-related changesC1q expressionSynapse lossBackgroundCognitive impairmentSpine lossComplement signalingInhibitory synapsesAnatomical distributionSynaptic localizationDisease pathogenesisGlial phagocytosisAlzheimer's diseaseClassical complementPrimate cortexPrefrontal cortex
2019
A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders
Duque A, Spector R. A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders. Brain Structure And Function 2019, 224: 2281-2295. PMID: 31278571, PMCID: PMC6852840, DOI: 10.1007/s00429-019-01917-6.Peer-Reviewed Original ResearchConceptsAdult human brainAdult neurogenesisHuman brainAdult human neurogenesisNormal neuronal circuitsBrain homeostatic systemsNeural stem cellsDentate gyrusBrain neuronsAdult brainCertain drugsNeuronal circuitsHigher cognitive functionsNeuropsychiatric disordersCognitive functionNeurogenesisHuman neurogenesisBrainHomeostatic systemNeuronsStem cellsRecent studiesPrevention of damageDifferent stimuliHumansGliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum
Rash BG, Duque A, Morozov YM, Arellano JI, Micali N, Rakic P. Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 7089-7094. PMID: 30894491, PMCID: PMC6452694, DOI: 10.1073/pnas.1822169116.Peer-Reviewed Original ResearchConceptsOuter subventricular zoneSubventricular zoneWhite matterCompletion of neurogenesisSuperficial layers IISubcortical white matterUnderlying white matterProduction of astrocytesRadial glial cellsElaboration of dendritesCortical surface areaSuperficial neuronsCerebral neuronsCortical connectionsGlial cellsCerebral convolutionsDay 90Layers IIFormation of convolutionsMacaque monkeysRapid enlargementCerebrumNeuronal growthNeuronsEmbryonic day 90
2016
Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates
Duque A, Krsnik Z, Kostović I, Rakic P. Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9892-9897. PMID: 27503885, PMCID: PMC5024589, DOI: 10.1073/pnas.1610078113.Peer-Reviewed Original ResearchConceptsSP neuronsSP cellsTransient embryonic zonesLayer 6 neuronsAssociation cortical areasTransient subplate zoneHuman postmortem tissuePositional changesAdequate experimental modelsEarly embryonic agesHuman subplateSubplate zoneBasal forebrainImmunohistochemical comparisonReplication markersCortical areasSP zoneMacaque monkeysPostmortem tissueVentricular zoneFetal ageCorticocortical axonsExperimental modelNonhuman primatesEmbryonic age
2014
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphateIntracellular Ca2Prefrontal cortical pyramidal neuronsReceptor-mediated intracellular Ca2Regulation of cAMPPrefrontal cortical slicesCortical pyramidal neuronsDISC1 functionMajor depressive disorderPyramidal neuron activityPatch-clamp recordingsTRPC channel activityDISC1 disruptionPrefrontal cortex activityPyramidal neuronsCortical slicesDepressive disorderAdult ratsIntracellular calcium wavesSustained depolarizationViral knockdownNeuron activityBipolar disorderMental disordersCAMP generation
2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2010
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2007
Morphological characterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropeptide Y-containing neurons
Duque A, Tepper JM, Detari L, Ascoli GA, Zaborszky L. Morphological characterization of electrophysiologically and immunohistochemically identified basal forebrain cholinergic and neuropeptide Y-containing neurons. Brain Structure And Function 2007, 212: 55-73. PMID: 17717698, DOI: 10.1007/s00429-007-0143-3.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAxonsBasal Nucleus of MeynertBrain MappingCell PolarityCell ShapeCholine O-AcetyltransferaseCholinergic FibersDendritesElectrophysiologyImage CytometryImmunohistochemistryLysineMaleNeural PathwaysNeuronsNeuropeptide YPresynaptic TerminalsRatsRats, Sprague-DawleySoftwareStaining and LabelingConceptsLocal axon collateralsNeuropeptide YBasal forebrainCholinergic neuronsAxon collateralsExtensive local axon collateralsBasal forebrain cholinergicBF cholinergic neuronsLocal axonal arborsCortical slow wavesCortical EEG activityDendritic arborization patternDendritic surface areaDistinct neuronal populationsForebrain cholinergicNPY neuronsBrainstem inputsDendritic thicknessAxonal arborsNeuronal firingArborization patternsSynaptic integrationNeuronal populationsCortical releaseCholinergicEnhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generationα2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell 2007, 129: 397-410. PMID: 17448997, DOI: 10.1016/j.cell.2007.03.015.Peer-Reviewed Original ResearchConceptsHCN channel blockadePrefrontal cortical neuronsDelay-related firingΑ2A adrenoceptorsChannel blockadeCortical neuronsInhibition of cAMPAlpha2A adrenoceptorsDendritic spinesNetwork firingElectrophysiological studiesPFC neuronsRecurrent excitationFunctional connectivityHCN channelsPrefrontal cortexHCN1 channelsPFC networksCAMP inhibitionStimulationBlockade
2006
Prenatal exposure to ultrasound waves impacts neuronal migration in mice
Ang ES, Gluncic V, Duque A, Schafer ME, Rakic P. Prenatal exposure to ultrasound waves impacts neuronal migration in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 12903-12910. PMID: 16901978, PMCID: PMC1538990, DOI: 10.1073/pnas.0605294103.Peer-Reviewed Original ResearchConceptsCortical layersPrenatal ultrasound exposureEmbryonic cerebral cortexSubjacent white matterSuperficial cortical layersSingle BrdU injectionEmbryonic day 16Non-human primatesDuration of exposureCerebral cortexLabel neuronsPrenatal exposureCerebral neocortexBrdU injectionFetal lifeWhite matterDay 16Neuronal positionNeuronal migrationOutside sequenceNeuronsProliferative zoneMiceFurther investigationUltrasound exposureNeocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibitionModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2000
Local synaptic connections of basal forebrain neurons
Zaborszky L, Duque A. Local synaptic connections of basal forebrain neurons. Behavioural Brain Research 2000, 115: 143-158. PMID: 11000417, DOI: 10.1016/s0166-4328(00)00255-2.Peer-Reviewed Original ResearchConceptsBasal forebrainLocal collateralsLocal synaptic connectionsBasal forebrain neuronsBasal forebrain regionsCholinergic neuronsElectron microscopic levelProjection neuronsCortical plasticityForebrain neuronsFrontal cortexForebrain regionsPutative interneuronsAxon arborsSynaptic connectionsNeural circuitryNeuronsForebrainInterneuronsIntegrative processingCollateralsNPYSomatostatinBiocytinCortexEEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain
Duque A, Balatoni B, Detari L, Zaborszky L. EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain. Journal Of Neurophysiology 2000, 84: 1627-1635. PMID: 10980032, DOI: 10.1152/jn.2000.84.3.1627.Peer-Reviewed Original ResearchConceptsLow-voltage fast activityBasal forebrainCortical slow wavesDistinct temporal relationshipsDifferent EEG patternsBF neuronsCortical circuitryCerebral hemispheresFast activityIdentified neuronsVentral aspectPeptidergic cellsCortical releaseFiring rateNeuron firingEEG patternsNeurons increasesNeuronsNeurotransmitter acetylcholineSlow wavesEEG correlationForebrainTemporal relationshipCell typesSpecific role