2023
Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeuronsOrigin and development of the claustrum in rhesus macaque
Li H, Duque A, Rakic P. Origin and development of the claustrum in rhesus macaque. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220918120. PMID: 37406098, PMCID: PMC10334778, DOI: 10.1073/pnas.2220918120.Peer-Reviewed Original Research
2020
Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Datta D, Leslie SN, Morozov YM, Duque A, Rakic P, van Dyck CH, Nairn AC, Arnsten AFT. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex. Journal Of Neuroinflammation 2020, 17: 8. PMID: 31906973, PMCID: PMC6945481, DOI: 10.1186/s12974-019-1683-1.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsComplement C1qMacaca mulattaNeuronsPrefrontal CortexRatsRats, Sprague-DawleyConceptsRat medial PFCPrimate dlPFCC1q levelsMedial PFCLayer IIIC1q proteinPrecise anatomical distributionMacaque dorsolateral prefrontal cortexAge-related degenerationDorsolateral prefrontal cortexAge-related changesC1q expressionSynapse lossBackgroundCognitive impairmentSpine lossComplement signalingInhibitory synapsesAnatomical distributionSynaptic localizationDisease pathogenesisGlial phagocytosisAlzheimer's diseaseClassical complementPrimate cortexPrefrontal cortex
2019
Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex
Datta D, Yang ST, Galvin VC, Solder J, Luo F, Morozov YM, Arellano J, Duque A, Rakic P, Arnsten A, Wang M. Noradrenergic α1-Adrenoceptor Actions in the Primate Dorsolateral Prefrontal Cortex. Journal Of Neuroscience 2019, 39: 2722-2734. PMID: 30755491, PMCID: PMC6445993, DOI: 10.1523/jneurosci.2472-18.2019.Peer-Reviewed Original ResearchConceptsΑ1-AR stimulationPosttraumatic stress disorderExcitatory effectsNeuronal firingDorsolateral prefrontal cortexBasal conditionsPrefrontal cortexΑ1-ARΑ1-adrenoceptorsInverted-U dose responseUncontrollable stressStress disorderTreatment of PTSDPrimate dorsolateral prefrontal cortexΑ1-AR expressionMajority of neuronsΑ1-AR agonistsPrefrontal cortical physiologyNoradrenergic releasePresynaptic excitationEndogenous NEPostsynaptic actionsExcitatory actionGlutamate releaseAxon terminals
2016
Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates
Duque A, Krsnik Z, Kostović I, Rakic P. Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9892-9897. PMID: 27503885, PMCID: PMC5024589, DOI: 10.1073/pnas.1610078113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineageCell MovementCerebral CortexGestational AgeHumansMacacaMacaca mulattaNeurogenesisNeuronsConceptsSP neuronsSP cellsTransient embryonic zonesLayer 6 neuronsAssociation cortical areasTransient subplate zoneHuman postmortem tissuePositional changesAdequate experimental modelsEarly embryonic agesHuman subplateSubplate zoneBasal forebrainImmunohistochemical comparisonReplication markersCortical areasSP zoneMacaque monkeysPostmortem tissueVentricular zoneFetal ageCorticocortical axonsExperimental modelNonhuman primatesEmbryonic age
2011
Different Effects of Bromodeoxyuridine and [3H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and Fate
Duque A, Rakic P. Different Effects of Bromodeoxyuridine and [3H]Thymidine Incorporation into DNA on Cell Proliferation, Position, and Fate. Journal Of Neuroscience 2011, 31: 15205-15217. PMID: 22016554, PMCID: PMC3225276, DOI: 10.1523/jneurosci.3092-11.2011.Peer-Reviewed Original Research
2007
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell 2007, 129: 397-410. PMID: 17448997, DOI: 10.1016/j.cell.2007.03.015.Peer-Reviewed Original ResearchConceptsHCN channel blockadePrefrontal cortical neuronsDelay-related firingΑ2A adrenoceptorsChannel blockadeCortical neuronsInhibition of cAMPAlpha2A adrenoceptorsDendritic spinesNetwork firingElectrophysiological studiesPFC neuronsRecurrent excitationFunctional connectivityHCN channelsPrefrontal cortexHCN1 channelsPFC networksCAMP inhibitionStimulationBlockade