2014
Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphateIntracellular Ca2Prefrontal cortical pyramidal neuronsReceptor-mediated intracellular Ca2Regulation of cAMPPrefrontal cortical slicesCortical pyramidal neuronsDISC1 functionMajor depressive disorderPyramidal neuron activityPatch-clamp recordingsTRPC channel activityDISC1 disruptionPrefrontal cortex activityPyramidal neuronsCortical slicesDepressive disorderAdult ratsIntracellular calcium wavesSustained depolarizationViral knockdownNeuron activityBipolar disorderMental disordersCAMP generation
2013
Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction
Gamo NJ, Duque A, Paspalas CD, Kata A, Fine R, Boven L, Bryan C, Lo T, Anighoro K, Bermudez L, Peng K, Annor A, Raja A, Mansson E, Taylor SR, Patel K, Simen AA, Arnsten AF. Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. Translational Psychiatry 2013, 3: e328-e328. PMID: 24301646, PMCID: PMC4030323, DOI: 10.1038/tp.2013.104.Peer-Reviewed Original ResearchConceptsPrefrontal cortexCyclic adenosine monophosphateMental illnessRestraint stressCognitive dysfunctionControl groupStress-induced cognitive dysfunctionPhosphodiesterase 4Schizophrenia 1Prefrontal cognitive dysfunctionMild restraint stressH restraint stressUnoperated control groupKD ratsDISC1 mutationViral knockdownNormal animalsPFC dysfunctionImpair functionIncreases SusceptibilityDysfunctionDISC1 geneIllnessCAMP levelsMultifunctional scaffolding protein