2021
An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group.
Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas AHEM, Prescott E, Karam N, Appelman Y, Fraccaro C, Buchanan GL, Manzo-Silberman S, Al-Lamee R, Regar E, Lansky A, Abbott JD, Badimon L, Duncker DJ, Mehran R, Capodanno D, Baumbach A. An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. EuroIntervention 2021, 16: 1049-1069. PMID: 32624456, PMCID: PMC9707543, DOI: 10.4244/eijy20m07_01.Peer-Reviewed Original ResearchConceptsNon-obstructive coronary arteriesConsensus documentCoronary arteryObstructive coronary artery diseaseCardiology Working GroupCoronary artery diseasePercutaneous Cardiovascular InterventionsInternational Study GroupExpert consensus documentQuality of lifeHealth care costsCoronary vasospasmINOCA patientsCardiovascular eventsMicrovascular dysfunctionAngina pectorisArtery diseaseHospital admissionCoronary pathophysiologyInvasive angiographyAsymptomatic individualsINOCAStudy groupClinical practiceCare costs
2020
An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group
Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas AHEM, Prescott E, Karam N, Appelman Y, Fraccaro C, Buchanan G, Manzo-Silberman S, Al-Lamee R, Regar E, Lansky A, Abbott JD, Badimon L, Duncker DJ, Mehran R, Capodanno D, Baumbach A. An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. European Heart Journal 2020, 41: 3504-3520. PMID: 32626906, PMCID: PMC7577516, DOI: 10.1093/eurheartj/ehaa503.Peer-Reviewed Original ResearchMeSH KeywordsCardiologyConsensusCoronary VesselsFemaleHumansIschemiaMaleMicrocirculationQuality of LifeConceptsNon-obstructive coronary arteriesConsensus documentCoronary arteryObstructive coronary artery diseaseCardiology Working GroupCoronary artery diseasePercutaneous Cardiovascular InterventionsInternational Study GroupExpert consensus documentQuality of lifeHealth care costsCoronary vasospasmINOCA patientsCardiovascular eventsMicrovascular dysfunctionAngina pectorisArtery diseaseHospital admissionCoronary pathophysiologyInvasive angiographyAsymptomatic individualsINOCAStudy groupClinical practiceCare costs
2015
Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction)
Prasad A, Gersh BJ, Mehran R, Brodie BR, Brener SJ, Dizon JM, Lansky AJ, Witzenbichler B, Kornowski R, Guagliumi G, Dudek D, Stone GW. Effect of Ischemia Duration and Door-to-Balloon Time on Myocardial Perfusion in ST-Segment Elevation Myocardial Infarction An Analysis From HORIZONS-AMI Trial (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction). JACC Cardiovascular Interventions 2015, 8: 1966-1974. PMID: 26738667, DOI: 10.1016/j.jcin.2015.08.031.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary CirculationDrug-Eluting StentsFemaleHumansMaleMetalsMicrocirculationMiddle AgedMyocardial InfarctionMyocardial Perfusion ImagingPercutaneous Coronary InterventionProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsStentsTime FactorsTime-to-TreatmentTreatment OutcomeConceptsPrimary percutaneous coronary interventionMyocardial blush gradePrimary PCIHORIZONS-AMI trialMBG 0/1Balloon timeIndependent predictorsAnterior infarctionMyocardial perfusionST-segment elevation myocardial infarction (STEMI) patientsST-segment elevation myocardial infarctionHigher clinical risk profileElevation myocardial infarction patientsMyocardial Infarction (TIMI) risk scoreClinical risk profileMechanical reperfusion therapyReference vessel diameterElevation myocardial infarctionPercutaneous coronary interventionST-segment elevationEpicardial blood flowMinimum lumen diameterMyocardial infarction patientsMicrovascular reperfusionBlush gradeCoronary Microvascular Dysfunction Does Sex Matter?∗
Lansky AJ, Pietras C. Coronary Microvascular Dysfunction Does Sex Matter?∗. JACC Cardiovascular Interventions 2015, 8: 1442-1444. PMID: 26404196, DOI: 10.1016/j.jcin.2015.04.026.Peer-Reviewed Original Research
2014
Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”
Majidi M, Kosinski AS, Al-Khatib SM, Smolders L, Cristea E, Lansky AJ, Stone GW, Mehran R, Gibbons RJ, Crijns HJ, Wellens HJ, Gorgels AP, Krucoff MW. Implications of ventricular arrhythmia “bursts” with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: A biosignature of direct myocellular injury “downstream of downstream”. European Heart Journal Acute Cardiovascular Care 2014, 4: 51-59. PMID: 25063574, DOI: 10.1177/2048872614532414.Peer-Reviewed Original ResearchConceptsST-segment recoveryMyocardial blush gradeST-segment elevation myocardial infarctionNormal epicardial flowTIMI 3 flowPercutaneous coronary interventionEpicardial flowLarger ISOptimal reperfusionVentricular arrhythmiasMyocellular injuryFinal TIMI 3 flowMyocardial Infarction 3 flowAnterior STEMI patientsElevation myocardial infarctionReperfusion ventricular arrhythmiasInfarct size assessmentMyocardial infarction reperfusionContinuous ECG monitoringMBG 2/3Myocardial ISBlush gradeSTEMI patientsCoronary interventionMyocardial reperfusion
2008
Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: Comparison with primary angioplasty and the role of distal protection devices (EMERALD trial)
Dangas G, Stone GW, Weinberg MD, Webb J, Cox DA, Brodie BR, Krucoff MW, Gibbons RJ, Lansky AJ, Mehran R, Investigators F. Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: Comparison with primary angioplasty and the role of distal protection devices (EMERALD trial). American Heart Journal 2008, 155: 1090-1096. PMID: 18513524, DOI: 10.1016/j.ahj.2007.12.003.Peer-Reviewed Original ResearchConceptsST-segment resolutionTIMI 3 flowDistal protection devicesPrimary PCIDistal protectionInfarct sizeRescue PCIPost-procedural TIMI 3 flowRescue percutaneous coronary interventionComplete ST-segment resolutionSimilar myocardial perfusionPercutaneous coronary interventionST-elevation MIAcute myocardial infarctionHigher baseline ratesPrespecified comparisonPCI patientsPrimary angioplastyMonth mortalityPrimary endpointCoronary interventionClinical outcomesMulticenter trialClinical eventsPatient population
2007
Relation Between Leucocyte Count, Myonecrosis, Myocardial Perfusion, and Outcomes Following Primary Angioplasty
Prasad A, Stone GW, Stuckey TD, Costantini CO, Mehran R, Garcia E, Tcheng JE, Cox DA, Grines CL, Lansky AJ, Gersh BJ. Relation Between Leucocyte Count, Myonecrosis, Myocardial Perfusion, and Outcomes Following Primary Angioplasty. The American Journal Of Cardiology 2007, 99: 1067-1071. PMID: 17437729, DOI: 10.1016/j.amjcard.2006.11.063.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary CirculationCreatine KinaseFemaleForecastingHumansLeukocyte CountLeukocytosisMaleMicrocirculationMiddle AgedMyocardial InfarctionMyocardial ReperfusionProspective StudiesRetrospective StudiesSmokingSurvival RateTreatment OutcomeConceptsPrimary percutaneous coronary interventionPrimary PCIBaseline leukocyte countAcute myocardial infarctionHigh leukocyte countLeukocyte countMyocardial perfusionMyocardial blush grade 2/3Myocardial infarction (TIMI) flowMyocardial blush gradePredictors of mortalityPercutaneous coronary interventionNegative prognostic factorPeak creatine phosphokinaseBaseline leukocytosisCADILLAC trialBlush gradePrimary angioplastyCoronary interventionCurrent smokersIndependent predictorsPrognostic factorsReperfusion successClinical outcomesGrade 2/3
2005
Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial
Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford BD, Antoniucci D, Krucoff MW, Gibbons RJ, Jones D, Lansky AJ, Mehran R, Investigators F. Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial. JAMA 2005, 293: 1063-1072. PMID: 15741528, DOI: 10.1001/jama.293.9.1063.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionST-segment resolutionAcute ST-segment elevation myocardial infarctionMajor adverse cardiac eventsAdverse cardiac eventsEvent-free survivalElevation myocardial infarctionDistal protectionInfarct sizeMyocardial infarctionCardiac eventsCoronary interventionReperfusion successBalloon occlusionEmergent percutaneous coronary interventionComplete ST-segment resolutionPrimary percutaneous coronary interventionEnd pointDistal balloon occlusionDistal embolic protectionPrimary PCI resultsCoprimary end pointsSecondary end pointsAcute myocardial infarctionCombined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction
Sorajja P, Gersh BJ, Costantini C, McLaughlin MG, Zimetbaum P, Cox DA, Garcia E, Tcheng JE, Mehran R, Lansky AJ, Kandzari DE, Grines CL, Stone GW. Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction. European Heart Journal 2005, 26: 667-674. PMID: 15734768, DOI: 10.1093/eurheartj/ehi167.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIPercutaneous coronary interventionST-segment recoveryMyocardial blushCoronary interventionMultivariable analysisPrognostic utilityMyocardial infarctionGreater prognostic utilityStrongest prognostic variableYear clinical outcomesIncremental prognostic informationCADILLAC trialReperfusion therapyReperfusion successClinical outcomesGrade 2/3Independent correlatesMicrocirculatory integrityPrognostic informationUnivariate analysisPoor survivalCumulative rate