2024
Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
Fezzi S, Ding D, Mahfoud F, Huang J, Lansky A, Tu S, Wijns W. Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? Nature Reviews Cardiology 2024, 21: 652-662. PMID: 38710772, DOI: 10.1038/s41569-024-01014-0.Peer-Reviewed Original ResearchPercutaneous coronary interventionOptimal revascularizationRisk of periprocedural myocardial infarctionCoronary interventionMyocardial infarctionStent-related eventsEfficacy of percutaneous coronary interventionCoronary artery diseasePeriprocedural myocardial infarctionAcute myocardial infarctionReperfusion of acute myocardial infarctionClinical successRevascularization outcomesArtery diseaseIncreased riskAngiographic guidancePercutaneous revascularizationRevascularizationPatientsIntracoronary imagingLincoffDiagnostic toolPhysiological assessment
2023
Effects of Elective Coronary Revascularization vs Medical Therapy Alone on Noncardiac Mortality A Meta-Analysis
Navarese E, Lansky A, Farkouh M, Grzelakowska K, Bonaca M, Gorog D, Raggi P, Kelm M, Yeo B, Umińska J, Curzen N, Kubica J, Wijns W, Kereiakes D. Effects of Elective Coronary Revascularization vs Medical Therapy Alone on Noncardiac Mortality A Meta-Analysis. JACC Cardiovascular Interventions 2023, 16: 1144-1156. PMID: 37225285, DOI: 10.1016/j.jcin.2023.02.030.Peer-Reviewed Original ResearchConceptsChronic coronary syndromeElective coronary revascularizationNoncardiac mortalityMedical therapyCoronary revascularizationTrial sequential analysisCumulative Z-curveRate ratioA Meta-AnalysisRandom-effects modelMeta-analysis findingsCoronary syndromeISCHEMIA trialRandomized trialsTrial evidenceRevascularizationTreatment groupsPrespecified endpointsMeta-AnalysisPatientsMortalityFutility boundariesDeath rateTrialsTreatment effects
2022
Current Landscape and Future Directions of Coronary Revascularization in Patients With Heart Failure
Ahmad Y, Lansky AJ, Velazquez EJ. Current Landscape and Future Directions of Coronary Revascularization in Patients With Heart Failure. JAMA Cardiology 2022, 7: 577-578. PMID: 35476046, DOI: 10.1001/jamacardio.2022.0659.Peer-Reviewed Original ResearchST-Segment Elevation Myocardial Infarction: Sex Differences in Incidence, Etiology, Treatment, and Outcomes
Shah T, Kapadia S, Lansky AJ, Grines CL. ST-Segment Elevation Myocardial Infarction: Sex Differences in Incidence, Etiology, Treatment, and Outcomes. Current Cardiology Reports 2022, 24: 529-540. PMID: 35286662, DOI: 10.1007/s11886-022-01676-7.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionMyocardial infarctionMechanical circulatory supportStandard of careSex-based disparitiesEvidence-based strategiesEarly revascularizationCirculatory supportPoor outcomeWorse outcomesYoung womenStandardized protocolWomenOutcomesInfarctionTreatmentEtiologySex differencesHeterogeneous entityRevascularizationPatientsDisparitiesPurposeAlthoughIncidence
2021
TCT-414 Safety and Efficacy of Dedicated Guidewire, Microcatheter, and Guide Catheter Extension Technologies for Chronic Total Coronary Occlusion Revascularization: Primary Results of the Teleflex Chronic Total Occlusion Study
Kandzari D, Alaswad K, Jaffer F, Brilakis E, Croce K, Kearney K, Spaedy A, Yeh R, Thompson C, Nicholson W, Wyman R, Riley R, Lansky A, Karmpaliotis D. TCT-414 Safety and Efficacy of Dedicated Guidewire, Microcatheter, and Guide Catheter Extension Technologies for Chronic Total Coronary Occlusion Revascularization: Primary Results of the Teleflex Chronic Total Occlusion Study. Journal Of The American College Of Cardiology 2021, 78: b169-b170. DOI: 10.1016/j.jacc.2021.09.1267.Peer-Reviewed Original ResearchCoronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis
Patel KP, Michail M, Treibel TA, Rathod K, Jones DA, Ozkor M, Kennon S, Forrest JK, Mathur A, Mullen MJ, Lansky A, Baumbach A. Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis. JACC Cardiovascular Interventions 2021, 14: 2083-2096. PMID: 34620388, DOI: 10.1016/j.jcin.2021.07.058.Peer-Reviewed Original ResearchConceptsAortic valve replacementCoronary artery diseaseAortic stenosisHemodynamic statusCoronary revascularizationValve replacementAssessment of CADPatients Undergoing Aortic Valve ReplacementConcomitant coronary artery diseaseImpact of ASSignificant coronary artery diseaseConcomitant aortic stenosisRole of revascularizationSevere aortic stenosisThird of patientsCohort of patientsDual pathologyArtery diseaseTherapeutic challengeCertain patientsMyocardial ischemiaCoronary assessmentPatientsRevascularizationMultidisciplinary team
2020
Long‐term serial functional evaluation after implantation of the Fantom sirolimus‐eluting bioresorbable coronary scaffold
Saito Y, Cristea E, Bouras G, Abizaid A, Lutz M, Carrié D, Weber‐Albers J, Dudek D, Anderson J, Lansky A, Investigators T. Long‐term serial functional evaluation after implantation of the Fantom sirolimus‐eluting bioresorbable coronary scaffold. Catheterization And Cardiovascular Interventions 2020, 97: 431-436. PMID: 32077590, DOI: 10.1002/ccd.28804.Peer-Reviewed Original ResearchConceptsPost-percutaneous coronary interventionQuantitative flow ratioBioresorbable coronary scaffoldTarget vessel revascularizationVessel revascularizationFunctional ischemiaStable coronary artery diseaseTime of revascularizationCoronary artery diseaseFractional flow reserveQFR assessmentII trialAngiographic outcomesCoronary interventionUnstable anginaArtery diseaseQFR valueWire-based fractional flow reserveSignificant lesionsFlow reservePatientsTarget vesselRevascularizationQFR analysisFunctional evaluation
2014
Short and long-term safety and efficacy of polymer-free vs. durable polymer drug-eluting stents. A comprehensive meta-analysis of randomized trials including 6178 patients
Navarese EP, Kowalewski M, Cortese B, Kandzari D, Dias S, Wojakowski W, Buffon A, Lansky A, Angelini P, Torguson R, Kubica J, Kelm M, de Boer MJ, Waksman R, Suryapranata H. Short and long-term safety and efficacy of polymer-free vs. durable polymer drug-eluting stents. A comprehensive meta-analysis of randomized trials including 6178 patients. Atherosclerosis 2014, 233: 224-231. PMID: 24529148, DOI: 10.1016/j.atherosclerosis.2013.12.024.Peer-Reviewed Original ResearchConceptsDurable polymer drug-eluting stentsDrug-eluting stentsStent thrombosisPolymer-free drug-eluting stentsRandomized trialsMyocardial infarctionMain efficacy endpointLong-term safetyLesion revascularizationEfficacy endpointSafety endpointVessel revascularizationMI ratesLong followCochrane DatabaseSafety profileClinical practiceRCTsGoogle ScholarConflicting resultsRevascularizationSignificant differencesEfficacyPatientsEndpoint
2012
Response to Letter Regarding Article, “Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes
Rosner G, Kirtane A, Genereux P, Lansky A, Cristea E, Weisz G, Parise H, Fahy M, Mehran R, Stone G, Gersh B. Response to Letter Regarding Article, “Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes. Circulation 2012, 126: e295. DOI: 10.1161/circulationaha.112.137752.Peer-Reviewed Original ResearchWhole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, Brown BO, Kraus WE, Schwartz RS, Voros S, Ellis SG, Waksman R, McPherson JA, Lansky AJ, Topol EJ, for the PREDICT Investigators. Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial. Journal Of Cardiovascular Translational Research 2012, 5: 366-374. PMID: 22396313, PMCID: PMC3349850, DOI: 10.1007/s12265-012-9353-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenetic TestingHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPhenotypePredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsStrokeTime FactorsUnited StatesConceptsMajor adverse cardiovascular eventsCoronary artery diseaseObstructive coronary artery diseaseGene expression scoreAdverse cardiovascular eventsCardiovascular eventsArtery diseaseClinical risk scoreGroup of patientsNegative predictive valueGene expression testingNondiabetic patientsPREDICT trialAngiography patientsGES groupPREDICT studyRisk scorePatientsPredictive valueExpression scoreRevascularizationEvent ratesDiseaseMonthsExpression testingIMPACT OF INCOMPLETE CORONARY REVASCULARIZATION ON ONE-YEAR OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN ACUTE CORONARY SYNDROMES: THE ACUITY TRIAL
Rosner G, Kirtane A, Genereux P, Lansky A, Cristea E, Gersh B, Weisz G, Parise H, Mehran R, Stone G. IMPACT OF INCOMPLETE CORONARY REVASCULARIZATION ON ONE-YEAR OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION IN ACUTE CORONARY SYNDROMES: THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2012, 59: e538. DOI: 10.1016/s0735-1097(12)60539-7.Peer-Reviewed Original ResearchThe Generations of Drug-Eluting Stents and Outcomes in Women
Ng VG, Lansky AJ. The Generations of Drug-Eluting Stents and Outcomes in Women. Interventional Cardiology Clinics 2012, 1: 183-195. PMID: 28582092, DOI: 10.1016/j.iccl.2012.01.002.Peer-Reviewed Original ResearchDrug-eluting stentsPercutaneous coronary artery revascularizationObstructive coronary artery diseaseCoronary artery revascularizationMinority of patientsCoronary artery diseaseCause of deathDrug-eluting stent technologyDrug eluting stentsArtery revascularizationArtery diseaseClinical trialsCardiovascular diseaseAntiproliferative drugsStentsStent technologyWomenStent platformsDiseaseOutcomesRevascularizationPatientsMainstayPrevalenceTrials
2011
PROGNOSTIC UTILITY OF PRE-PROCEDURAL TIMI FLOW IN PATIENTS WITH NON ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES UNDERGOING PERCUTANEOUS CORONARY REVASCULARIZATION: THE ACUITY TRIAL
De Luca G, Brener S, Mehran R, Lansky A, Cristea E, Fahy M, Stone G. PROGNOSTIC UTILITY OF PRE-PROCEDURAL TIMI FLOW IN PATIENTS WITH NON ST-SEGMENT ELEVATION ACUTE CORONARY SYNDROMES UNDERGOING PERCUTANEOUS CORONARY REVASCULARIZATION: THE ACUITY TRIAL. Journal Of The American College Of Cardiology 2011, 57: e1649. DOI: 10.1016/s0735-1097(11)61649-5.Peer-Reviewed Original Research
2009
Safety and Efficacy of Drug-Eluting and Bare Metal Stents
Kirtane AJ, Gupta A, Iyengar S, Moses JW, Leon MB, Applegate R, Brodie B, Hannan E, Harjai K, Jensen LO, Park SJ, Perry R, Racz M, Saia F, Tu JV, Waksman R, Lansky AJ, Mehran R, Stone GW. Safety and Efficacy of Drug-Eluting and Bare Metal Stents. Circulation 2009, 119: 3198-3206. PMID: 19528338, DOI: 10.1161/circulationaha.108.826479.Peer-Reviewed Original ResearchConceptsBare metal stentsDrug-eluting stentsTarget vessel revascularizationMyocardial infarctionVessel revascularizationObservational studyMetal stentsEfficacy end pointTotal patientsOverall mortalityDrug-ElutingDES useLabel indicationsLabel useResidual confoundingBMS useRCTsPatientsDrug AdministrationInfarctionRevascularizationEnd pointMortality dataComparable reductionStents
2004
Outcomes of percutaneous and surgical revascularization in women
Lansky AJ. Outcomes of percutaneous and surgical revascularization in women. Progress In Cardiovascular Diseases 2004, 46: 305-319. PMID: 14961454, DOI: 10.1016/j.pcad.2003.08.004.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseUnstable coronary artery syndromesCoronary artery syndromeSurgical treatment modalitiesGender-related differencesSurgical revascularizationRevascularization strategyArtery diseaseSpecific pathophysiologyTreatment modalitiesNatural historyOutcomesWomenRevascularizationPatientsPathophysiologySyndromeDisease
2003
Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Stone GW, Leon MB. Usefulness of the angiographic pattern of in-stent restenosis in predicting the success of gamma vascular brachytherapy. The American Journal Of Cardiology 2003, 92: 1214-1217. PMID: 14609602, DOI: 10.1016/j.amjcard.2003.07.036.Peer-Reviewed Original ResearchConceptsStent restenosisAngiographic patternsVascular brachytherapyMajor adverse cardiac event ratesAdverse cardiac event ratesBinary angiographic restenosis rateAngiographic restenosis rateCardiac event rateStent restenosis patternsRestenosis patternLesion revascularizationPrognostic roleRestenosis rateTotal occlusionClinical trialsProliferative patternEvent ratesRestenosisPooled data setBrachytherapyRevascularizationPatientsAngiogramsBaselineTrialsLong-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III)
Limpijankit T, Mehran R, Mintz GS, Dangas G, Lansky AJ, Kao J, Ashby DT, Moussa I, Stone GW, Moses JW, Leon MB, Teirstein PS. Long-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III). The American Journal Of Cardiology 2003, 92: 315-318. PMID: 12888143, DOI: 10.1016/s0002-9149(03)00636-2.Peer-Reviewed Original ResearchConceptsAdverse eventsCoronary Artery Bypass GraftingTotal adverse eventsArtery Bypass GraftingCoronary artery bypassFirst-line therapyPercutaneous coronary interventionLong-term outcomesBrachytherapy failureArtery bypassBypass GraftingVessel revascularizationCoronary interventionIndependent predictorsMyocardial infarctionRadiation failureStent restenosisLate thrombosisPatientsTherapyBrachytherapyRevascularizationInfarctionThrombosisFailure
2002
Minimally invasive direct coronary artery bypass (MIDCAB) versus coronary artery stenting for elective revascularization of the left anterior descending artery
Iakovou I, Dangas G, Mehran R, Lansky AJ, Stamou SC, Pfister AJ, Dullum MK, Leon MB, Corso PJ. Minimally invasive direct coronary artery bypass (MIDCAB) versus coronary artery stenting for elective revascularization of the left anterior descending artery. The American Journal Of Cardiology 2002, 90: 885-887. PMID: 12372581, DOI: 10.1016/s0002-9149(02)02715-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngioplasty, Balloon, CoronaryCardiopulmonary BypassCause of DeathCoronary Artery BypassCoronary DiseaseCosts and Cost AnalysisFemaleHospital MortalityHumansInternal Mammary-Coronary Artery AnastomosisLength of StayMaleMiddle AgedMinimally Invasive Surgical ProceduresRetrospective StudiesStentsSurvival RateThoracotomyRandomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis
Popma JJ, Suntharalingam M, Lansky AJ, Heuser RR, Speiser B, Teirstein PS, Massullo V, Bass T, Henderson R, Silber S, von Rottkay P, Bonan R, Ho KK, Osattin, MPH A, Kuntz RE. Randomized Trial of 90Sr/90Y β-Radiation Versus Placebo Control for Treatment of In-Stent Restenosis. Circulation 2002, 106: 1090-1096. PMID: 12196334, DOI: 10.1161/01.cir.0000027814.96651.72.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationStent restenosisPlacebo-treated patientsPrimary end pointCatheter-based treatmentIn-Stent RestenosisPlacebo sourcesStent thrombosesAngiographic restenosisClinical restenosisFirst multicenterIntracoronary radiationMyocardial infarctionPlacebo controlPatientsPrescribed doseRestenosisConventional treatmentIntracoronary catheterEnd pointDay 244PlaceboRevascularizationTreatmentIncidenceDirect stenting improves target lesion revascularization in saphenous vein graft lesions: an intravascular ultrasound-guided study
Abizaid A, Mehran R, Mintz G, Lansky A, Stone G, Abizaid A, Dangas G, Limpijankit T, Iakovou Y, Moses J, Leon M. Direct stenting improves target lesion revascularization in saphenous vein graft lesions: an intravascular ultrasound-guided study. Journal Of The American College Of Cardiology 2002, 39: 35. DOI: 10.1016/s0735-1097(02)80150-4.Peer-Reviewed Original Research