2024
Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI
Abu-Much A, Grines C, Chen S, Batchelor W, Zhao D, Falah B, Maini A, Redfors B, Bellumkonda L, Bharadwaj A, Moses J, Truesdell A, Zhang Y, Zhou Z, Baron S, Lansky A, Basir M, O'Neill W, Cohen D. Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI. International Journal Of Cardiology 2024, 417: 132555. PMID: 39270940, DOI: 10.1016/j.ijcard.2024.132555.Peer-Reviewed Original ResearchLower left ventricular ejection fractionMitral valve regurgitationPercutaneous coronary interventionHigh-risk PCISevere MRHigh-risk percutaneous coronary interventionMR severityPCI-related complicationsValve regurgitationIII studiesHeart failureAssociated with worse outcomesPrevalence of heart failurePresence of severe MRLower body mass indexVentricular ejection fractionStatistical significanceHigh-risk PCI patientsBody mass indexTrace MREjection fractionModerate MRClinical outcomesMild MRWorse outcomesAngiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Bharadwaj A, Abu-Much A, Maini A, Zhou Z, Li Y, Batchelor W, Grines C, Baron S, Redfors B, Lansky A, Basir M, O’Neill W. Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study. Circulation Cardiovascular Interventions 2024, 17: e013503. PMID: 38708609, PMCID: PMC11239095, DOI: 10.1161/circinterventions.123.013503.Peer-Reviewed Original ResearchChronic kidney diseaseHigh-risk percutaneous coronary interventionPercutaneous coronary interventionAdvanced chronic kidney diseaseIII studiesCerebrovascular eventsAngiographic characteristicsClinical outcomesCoronary calcificationCoronary interventionSevere coronary calcificationCardiac Surgery scoreHigh-risk patientsLong-term outcomesPercutaneous coronary intervention complicationsPCI-related complicationsPrevalence of hypertensionPeripheral arterial diseaseCoronary complicationsBaseline comorbiditiesSurgery scoreArtery diseasePrimary outcomeEGFRKidney diseaseAssociation of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention
Medranda G, Faraz H, Thompson J, Zhang Y, Bharadwaj A, Osborn E, Abu-Much A, Lansky A, Basir M, Moses J, O’Neill W, Grines C, Baron S. Association of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101981. PMID: 39166169, PMCID: PMC11330901, DOI: 10.1016/j.jscai.2024.101981.Peer-Reviewed Original ResearchSYNTAX I scoreHigh-risk percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionSYNTAX IIII studiesSYNTAX scoreI scoresAssociated with higher ratesComplex coronary artery diseaseCoronary artery diseaseMultivariate regression analysisMechanical circulatory supportInterventionClinical outcomesPoor outcomeCerebrovascular eventsRegression analysisArtery diseasePost-PCIPatientsCirculatory supportProcedural factorsHigher ratesOutcomes
2023
Characteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support
Jakob P, Falah B, Abu-Much A, Lansky A, Basir M, Schonning M, Zhou Z, Batchelor W, Grines C, O'neill W, Stahli B. Characteristics and outcomes of elderly patients undergoing protected percutaneous coronary intervention with impella mechanical circulatory support. European Heart Journal 2023, 44: ehad655.2209. DOI: 10.1093/eurheartj/ehad655.2209.Peer-Reviewed Original ResearchHigh-risk percutaneous coronary interventionPercutaneous coronary interventionMechanical circulatory supportYears of ageCirculatory supportMyocardial infarctionCoronary interventionElderly patientsClinical outcomesStroke/transient ischemic attackMain percutaneous coronary interventionMultivariable Cox regression modelsSevere valvular heart diseaseLeft ventricular ejection fractionLower body mass indexBaseline SYNTAX scoreTransient ischemic attackHigh-risk patientsGlomerular filtration ratePrior myocardial infarctionVentricular ejection fractionValvular heart diseaseBody mass indexCox regression modelRisk of mortalitySex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study
Shah T, Abu-Much A, Batchelor W, Grines C, Baron S, Zhou Z, Li Y, Maini A, Redfors B, Hussain Y, Wollmuth J, Basir M, O'Neill W, Lansky A. Sex Differences in pLVAD-Assisted High-Risk Percutaneous Coronary Intervention Insights From the PROTECT III Study. JACC Cardiovascular Interventions 2023, 16: 1721-1729. PMID: 37409991, DOI: 10.1016/j.jcin.2023.04.036.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionFemale patientsIII studySex-based differencesImmediate PCISYNTAX scoreClinical outcomesMyocardial infarctionStroke/transient ischemic attackWorse renal functionAcute limb ischemiaTransient ischemic attackSex differencesPercutaneous coronary interventionAcute myocardial infarctionHigher ejection fractionCause deathCoronary complicationsIschemic attackMajor bleedingNonfemoral accessPercutaneous CoronaryPrior strokeCerebrovascular eventsVascular complicationsProspective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis
Dolmatch B, Cabrera T, Pergola P, Balamuthusamy S, Makris A, Cooper R, Moore E, Licht J, Macaulay E, Maleux G, Pfammatter T, Settlage R, Cristea E, Lansky A, Investigators A, Dolmatch B, Goh G, Hawkins S, Macaulay E, Spark I, de Graff R, Deutschmann H, Kickuth R, Maleux G, Pfammatter T, Kirksey L, Mendes R, Aruny J, Ali V, Cabrera T, Pergola P, Sharma D, Moore E, Shah H, Dwyer A, Yee D, Teng W, Cooper R, Balamuthusamy S, Lipkowitz G, Saad T, Licht J, Makris A, Rogers T, Burgess J, Hoggard J. Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis. Kidney International 2023, 104: 189-200. PMID: 36990214, DOI: 10.1016/j.kint.2023.03.015.Peer-Reviewed Original ResearchConceptsTarget lesion primary patencyAccess circuit primary patencyPercutaneous transluminal angioplastyTarget lesion reinterventionPrimary patencyTransluminal angioplastyArteriovenous fistulaAVF stenosisAdditional clinical outcomesCircuit primary patencyCovered stent groupLesion primary patencyMulticenter clinical studyHemodialysis arteriovenous fistula stenosisArteriovenous fistula stenosisHemodialysis patientsPrimary outcomeRandomized studyClinical outcomesAVF dysfunctionStent groupClinical studiesFistula stenosisSix monthsPatientsEffect of Race on Clinical Outcomes Following Hemodynamically Supported High-Risk Percutaneous Coronary Intervention
Fuller B, Basir M, Grines C, Voeltz M, Batchelor W, Lansky A, O’Neill W. Effect of Race on Clinical Outcomes Following Hemodynamically Supported High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100588. PMID: 39129816, PMCID: PMC11307497, DOI: 10.1016/j.jscai.2023.100588.Peer-Reviewed Original Research
2022
Geographic Variations on the Safety and Efficacy of the Supreme Biodegradable Polymer DES: Results From PIONEER III
Garot P, Leon M, Saito S, Baumbach A, Kereiakes D, Windecker S, Pietras C, Dressler O, Issever M, Curtis M, Bertolet B, Zidar J, Smits P, Diaz V, McLaurin B, Cequier A, Hofma S, Dib N, Namiki A, Takahashi A, Kakuta T, Hirohata A, Lansky A. Geographic Variations on the Safety and Efficacy of the Supreme Biodegradable Polymer DES: Results From PIONEER III. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 2: 100515. PMID: 39132534, PMCID: PMC11308104, DOI: 10.1016/j.jscai.2022.100515.Peer-Reviewed Original ResearchDrug-eluting stentsDurable polymer everolimus-eluting stentsEverolimus-eluting stentsIII trialsLesion failureClinical outcomesMyocardial infarctionMajor adverse cardiac eventsVessel-related myocardial infarctionBiodegradable polymer drug-eluting stentsAdverse cardiac eventsOutcomes of patientsTarget lesion failureTarget lesion revascularizationLesion revascularizationCardiac eventsPatient characteristicsCardiac deathDES groupProcedural successStent thrombosisSubgroup analysisPatient outcomesNonsignificant trendEnrollment locationIntravascular Imaging for Guiding In‐Stent Restenosis and Stent Thrombosis Therapy
Erdogan E, Bajaj R, Lansky A, Mathur A, Baumbach A, Bourantas C. Intravascular Imaging for Guiding In‐Stent Restenosis and Stent Thrombosis Therapy. Journal Of The American Heart Association 2022, 11: e026492. PMID: 36326067, PMCID: PMC9750080, DOI: 10.1161/jaha.122.026492.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary interventionStent failureStent restenosisStent thrombosisSecond-generation drug-eluting stentsConventional percutaneous coronary interventionHigh-risk patientsBetter clinical outcomesLong-term outcomesDrug-eluting stentsCumulative incidenceClinical outcomesWorse prognosisProcedural resultsComplex anatomyEndovascular devicesRestenosisTherapyStent technologyDrug kineticsIntravascular imagingTreatment planningNeointima tissueThrombosisTCT-58 FANTOM II Trial: Safety and Performance Study of the Fantom Sirolimus-Eluting Bioresorbable Coronary Scaffold—Final: 5-Year Clinical Outcomes
Lutz M, Abizaid A, Carrie D, Dudek D, Lansky A. TCT-58 FANTOM II Trial: Safety and Performance Study of the Fantom Sirolimus-Eluting Bioresorbable Coronary Scaffold—Final: 5-Year Clinical Outcomes. Journal Of The American College Of Cardiology 2022, 80: b23-b24. DOI: 10.1016/j.jacc.2022.08.070.Peer-Reviewed Original ResearchBioresorbable coronary scaffoldClinical outcomesPCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes
Ahmad Y, Petrie M, Jolicoeur E, Madhavan M, Velazquez E, Moses J, Lansky A, Stone G. PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100020. PMID: 39132568, PMCID: PMC11307477, DOI: 10.1016/j.jscai.2022.100020.Peer-Reviewed Original ResearchPercutaneous coronary interventionLeft ventricular systolic dysfunctionCoronary artery diseaseHeart failureComplete revascularizationMedical therapyClinical outcomesClinical trialsCoronary artery bypassVentricular systolic dysfunctionClinical trial evidenceHigh operative riskHigh-risk patientsMajor cardiac surgeryExtent of revascularizationMinority of patientsFuture clinical trialsArtery bypassCause mortalityPeriprocedural complicationsSystolic dysfunctionCoronary interventionOperative riskArtery diseaseCardiac surgery
2021
Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction
Shah T, Haimi I, Yang Y, Gaston S, Taoutel R, Mehta S, Lee HJ, Zambahari R, Baumbach A, Henry TD, Grines CL, Lansky A, Tirziu D. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2021, 147: 23-32. PMID: 33640366, DOI: 10.1016/j.amjcard.2021.02.015.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIMyocardial infarctionMajor bleedingBalloon timeST-segment elevation myocardial infarctionMyocardial infarction outcomesRepeat myocardial infarctionFirst medical contactElevation myocardial infarctionPercutaneous coronary interventionSpecific patient characteristicsRate of mortalityAspirin usageMore comorbiditiesAntiplatelet therapyHospital outcomesP2Y12 inhibitorsCoronary interventionLonger doorPatient characteristicsMedical contactClinical outcomesGender disparitiesSuboptimal treatment
2020
Does the operator's sex matter? An analysis based on the national interventional cardiology registry.
Lanocha M, Lansky A, Siudak Z, Włodarczak A, Tarchalski J, Malinowski KP, Laskowski W, Sikora T, Radziszewska E, Dolecka-Ślusarczyk M, Wojakowski W, Bartuś S, Grygier M, Tokarek T, Dudek D, Lesiak M. Does the operator's sex matter? An analysis based on the national interventional cardiology registry. Kardiologia Polska 2020, 78: 1221-1226. PMID: 33146499, DOI: 10.33963/kp.15665.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPractice patternsOutcomes of PCIInterventional cardiologyInterventional Cardiology RegistryCardiovascular risk factorsAcute coronary syndromeSingle-vessel diseaseCoronary artery interventionInvasive cardiology proceduresSex matterMale operatorsCardiology RegistryCoronary syndromeCoronary interventionArtery interventionMore patientsClinical outcomesMain indicationsNational registryRisk factorsMedian numberContrast dosesLow prevalenceHigh dosesManagement of myocardial revascularisation failure: an expert consensus document of the EAPCI.
Stefanini GG, Alfonso F, Barbato E, Byrne RA, Capodanno D, Colleran R, Escaned J, Giacoppo D, Kunadian V, Lansky A, Mehilli J, Neumann FJ, Regazzoli D, Sanz-Sanchez J, Wijns W, Baumbach A. Management of myocardial revascularisation failure: an expert consensus document of the EAPCI. EuroIntervention 2020, 16: e875-e890. PMID: 32597391, DOI: 10.4244/eij-d-20-00487.Peer-Reviewed Original ResearchConceptsConsensus documentLong-term clinical outcomesRepeat revascularisation proceduresCoronary artery bypassPercutaneous coronary interventionCoronary artery diseasePercutaneous Cardiovascular InterventionsNative coronary segmentsDrug-eluting stentsExpert consensus documentArterial bypass graftsSignificant economic burdenPatient-oriented approachArtery bypassMyocardial revascularisationRepeat revascularisationRevascularisation proceduresCoronary interventionArtery diseaseBypass graftClinical outcomesRevascularisation techniquesPatients' qualityClinical managementCoronary segmentsSafety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies
Blachutzik F, Honton B, Escaned J, Hill JM, Werner N, Banning AP, Lansky AJ, Schlattner S, De Bruyne B, Di Mario C, Dörr O, Hamm C, Nef HM. Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies. Clinical Research In Cardiology 2020, 110: 228-236. PMID: 32948882, PMCID: PMC7862504, DOI: 10.1007/s00392-020-01737-3.Peer-Reviewed Original ResearchConceptsCoronary intravascular lithotripsyIntravascular lithotripsyCalcified coronary lesionsII studyResidual stenosisCoronary lesionsCAD IPooled patient-level analysisFinal residual stenosisPercent residual stenosisFlow-limiting dissectionPatient-level analysisPatient-level dataHospital MACEIVL useAcute gainClinical outcomesConcentric lesionsEccentric lesionsCalcified lesionsAbrupt closureReflow eventsResultsClinical successStenosisConcentric stenosisFrequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race
Kim Y, Park J, Essa M, Lansky AJ, Sugeng L. Frequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race. The American Journal Of Cardiology 2020, 125: 1782-1787. PMID: 32471549, DOI: 10.1016/j.amjcard.2020.03.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMechanical circulatory supportCardiogenic shockNational Inpatient SampleHospital mortalityBlack patientsInpatient SampleMCS devicesPopulation-based retrospective cohort studyMCS utilizationMechanical circulatory support devicesOnly black patientsRetrospective cohort studyClinical Modification codesMultivariate logistic regressionCirculatory support devicesAcute clinical scenariosHospital outcomesCohort studyPrimary outcomeClinical outcomesHospital eventsCirculatory supportNinth RevisionMyocardial infarctionThe Firehawk Stent: A Review of a Novel Abluminal Groove-Filled Biodegradable Polymer Sirolimus-Eluting Stent.
Saito Y, Grubman D, Cristea E, Lansky A. The Firehawk Stent: A Review of a Novel Abluminal Groove-Filled Biodegradable Polymer Sirolimus-Eluting Stent. Cardiology In Review 2020, 28: 208-212. PMID: 32032131, DOI: 10.1097/crd.0000000000000298.Peer-Reviewed Original ResearchConceptsAbluminal grooveFIREHAWK stentBiodegradable Polymer Sirolimus-Eluting StentLate adverse eventsPercutaneous coronary interventionCurrent clinical evidenceSirolimus-Eluting StentsDrug-eluting stent technologyAdverse eventsCoronary interventionClinical outcomesChronic inflammationClinical evidenceHypersensitivity reactionsRecent trialsDrug concentrationsStent technologyStentsInflammationFIREHAWKReviewSirolimus
2019
Clinical outcomes of complex lesions treated with an abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent and durable polymer everolimus‐eluting stent
Saito Y, Baumbach A, Wijns W, Xu B, Kelbæk H, Zheng M, Morel M, Anderson R, Schächinger V, Lansky A, Investigators T. Clinical outcomes of complex lesions treated with an abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent and durable polymer everolimus‐eluting stent. Catheterization And Cardiovascular Interventions 2019, 96: 1023-1028. PMID: 31769161, DOI: 10.1002/ccd.28609.Peer-Reviewed Original ResearchConceptsHigh-risk patientsClinical outcomesComer studyI trialDurable polymer everolimus-eluting stentsTarget vessel myocardial infarctionSirolimus-eluting coronary stentYear clinical outcomesTarget lesion failureVessel myocardial infarctionLow-risk patientsWorse clinical outcomesEverolimus-eluting stentsHigh-risk groupLow-risk groupStrict eligibility criteriaFIREHAWK stentLesion failurePrimary endpointRandomized trialsMyocardial infarctionRisk groupsInclusion criteriaComplex lesionsXIENCE stentTCT-287 Impact of Eligibility Criteria on Clinical Outcomes of Firehawk and XIENCE Coronary Drug-Eluting Stent in an All-Comers Randomized Trial
Saito Y, Wijns W, Baumbach A, Xu B, Kelbæk H, van Royen N, Zheng M, Knaapen P, Slagboom T, Johnson T, Vlachojannis G, Holmvang L, Janssens L, Ochala A, Brugaletta S, Anderson R, Rittger H, Berti S, Barbato E, Toth G, Maillard L, Valina C, Buszman P, Thiele H, Lansky A. TCT-287 Impact of Eligibility Criteria on Clinical Outcomes of Firehawk and XIENCE Coronary Drug-Eluting Stent in an All-Comers Randomized Trial. Journal Of The American College Of Cardiology 2019, 74: b286. DOI: 10.1016/j.jacc.2019.08.361.Peer-Reviewed Original Research2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent
Xu B, Saito Y, Baumbach A, Kelbæk H, van Royen N, Zheng M, Morel MA, Knaapen P, Slagboom T, Johnson TW, Vlachojannis G, Arkenbout KE, Holmvang L, Janssens L, Ochala A, Brugaletta S, Naber CK, Anderson R, Rittger H, Berti S, Barbato E, Toth GG, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Lansky A, Wijns W, Investigators T. 2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent. JACC Cardiovascular Interventions 2019, 12: 1679-1687. PMID: 31129092, DOI: 10.1016/j.jcin.2019.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsCoronary Artery DiseaseCoronary ThrombosisDrug-Eluting StentsDual Anti-Platelet TherapyEuropeEverolimusFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPolymersProspective StudiesProsthesis DesignRisk FactorsSirolimusTime FactorsTreatment OutcomeConceptsTarget lesion failureXIENCE stentXience groupLesion failurePrimary endpointClinical outcomesIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionProbable stent thrombosisTarget lesion revascularizationVessel myocardial infarctionLong-term outcomesDurable polymer everolimusBiodegradable Polymer SirolimusAbluminal grooveFIREHAWK stentLesion revascularizationCardiac deathComparable safetyStent thrombosisMyocardial infarctionClinical trialsEfficacy profileNoninferiority trialLandmark analysis