2024
Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring Treatment
Kiwan A, Kewan T, Bravo-Perez C, Visconte V, Gurnari C, Durmaz A, Siddon A, Halene S, Sethi T, Maciejewski J, Foss F. Clinically Driven Algorithms Identify Patients with Large Granular Lymphocytic Leukemia at Risk of Significant Cytopenia Requiring Treatment. Blood 2024, 144: 4436. DOI: 10.1182/blood-2024-209344.Peer-Reviewed Original ResearchT-cell rearrangementArea under the curveGranular lymphocytic leukemiaMonoclonal gammopathyUnivariate analysisRheumatoid arthritisMyelodysplastic syndromeClonal hematopoiesisMedian ageLymphocytic leukemiaFactors associated with anemiaAbsence of CD4Associated with cytopeniaHistory of rheumatoid arthritisAssociated with neutropeniaExpression of CD5Presence of splenomegalyTreatment requirementsAssociated with anemiaMultivariate logistic regression modelPrimary etiological factorMultivariate regressionPersonalized treatment strategiesUnivariate logistic regressionAssociated with treatment
2020
How I Diagnose Low-Grade Myelodysplastic Syndromes
Siddon AJ, Hasserjian RP. How I Diagnose Low-Grade Myelodysplastic Syndromes. American Journal Of Clinical Pathology 2020, 154: 5-14. PMID: 32458977, DOI: 10.1093/ajcp/aqaa046.Peer-Reviewed Original ResearchConceptsLow-grade myelodysplastic syndromesMyelodysplastic syndromeMorphologic dysplasiaPeripheral blood cytopeniasCauses of cytopeniaDifficult diagnostic dilemmaBone marrow morphologyClonal genetic abnormalitiesRole of pathologistsBlood cytopeniasPeripheral bloodClinical recordsDiagnostic dilemmaMarrow morphologySecondary causesAncillary studiesIneffective hematopoiesisMyeloid neoplasmsMDS casesClinical heterogeneityDiagnostic algorithmResults of cytogeneticsGenetic abnormalitiesClonal hematopoiesisIndeterminate potential