2024
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024 PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysisDiastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Fava A, Popovic Z, Alashi A, Thamilarasan M, Xu B, Desai M. Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity. The American Journal Of Cardiology 2024, 232: 34-40. PMID: 39307332, DOI: 10.1016/j.amjcard.2024.09.017.Peer-Reviewed Original ResearchTreadmill exercise echocardiographyHypertrophic cardiomyopathyCongestive heart failureDiastolic parametersExercise capacityStress echocardiographyAssociated with reduced exercise capacityPrecipitate congestive heart failureLeft ventricular (LVAsymptomatic/minimally symptomatic patientsDiastolic stress echocardiographyMultivariate logistic regression analysisSymptomatic HCM patientsEtiology of dyspneaHigher body mass indexBody mass indexReduced exercise capacityExercise functional capacityLogistic regression analysisAssociated with <Incremental diagnostic utilityHigher LAViLVOT gradientE/e' ratioDiastolic dysfunction
2022
Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Wadhwa R, Fava A, Lever HM, Thamilarasan M, Popovic ZB, Smedira NG, Desai MY. Prognostic value of age-sex adjusted NT-proBNP ratio in obstructive hypertrophic cardiomyopathy. Progress In Cardiovascular Diseases 2022, 74: 11-18. PMID: 35952727, DOI: 10.1016/j.pcad.2022.08.002.Peer-Reviewed Original ResearchConceptsSeptal reduction therapyBNP ratioNT-proBNP ratioPrimary outcomeAsymptomatic patientsPrognostic valueObstructive hypertrophic cardiomyopathy patientsIncremental prognostic valueNormal NT-proBNPNT-pro BNPObstructive hypertrophic cardiomyopathyLong-term outcomesHypertrophic cardiomyopathy patientsCardiac transplantationNT-proBNPPrimary endpointCardiomyopathy patientsHypertrophic cardiomyopathyReduction therapyHigh riskPatientsDefibrillator dischargeSpline analysisOutcomesBNP
2021
Predictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy
Hutt E, Mentias A, Alashi A, Fava A, Popovic Z, Thamilarasan M, Lever H, Desai M. Predictive value of NT-proBNP in non-obstructive hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0765. DOI: 10.1093/eurheartj/ehab724.0765.Peer-Reviewed Original ResearchNT-proBNP ratioLV ejection fractionSerum NT-proBNPNT-proBNPAsymptomatic patientsPrimary endpointSeptal myectomySudden cardiac death risk factorsNon-obstructive hypertrophic cardiomyopathyKaplan-Meier survival analysisDeath risk factorsEarly disease stagesHypertrophic cardiomyopathy patientsImplantable defibrillator dischargesEjection fractionHeart transplantPrimary outcomeRisk stratificationPrognostic valueAdverse outcomesDisease stageCardiomyopathy patientsRisk factorsEcho variablesHypertrophic cardiomyopathyOutcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thicknessCharacteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy
Alashi A, Smedira NG, Popovic ZB, Fava A, Thamilarasan M, Kapadia SR, Wierup P, Lever HM, Desai MY. Characteristics and Outcomes of Elderly Patients With Hypertrophic Cardiomyopathy. Journal Of The American Heart Association 2021, 10: e018527. PMID: 33506683, PMCID: PMC7955450, DOI: 10.1161/jaha.120.018527.Peer-Reviewed Original ResearchConceptsLeft ventricular outflow tract gradientVentricular outflow tract gradientOutflow tract gradientElderly patientsHypertrophic cardiomyopathyTract gradientObstructive subgroupRisk factorsDynamic left ventricular outflow tract obstructionSudden cardiac death risk factorsLeft ventricular outflow tract obstructionAppropriate internal defibrillator dischargeVentricular outflow tract obstructionBasal septal thicknessConclusion Elderly patientsDeath risk factorsSeptal reduction therapyThoracic Surgeons scoreConsecutive elderly patientsOutflow tract obstructionVentricular mass indexBasal septal hypertrophyLong-term outcomesHospital deathTract obstruction
2020
Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy
Alashi A, Smedira NG, Hodges K, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Desai MY. Outcomes in Guideline‐Based Class I Indication Versus Earlier Referral for Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy. Journal Of The American Heart Association 2020, 10: e016210. PMID: 33342243, PMCID: PMC7955478, DOI: 10.1161/jaha.120.016210.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresCardiomyopathy, HypertrophicDissectionEarly Medical InterventionEchocardiography, StressExercise TestFemaleHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsVentricular outflow tract gradientObstructive coronary artery diseaseBetter long-term survivalSurgical myectomyOutflow tract gradientObstructive hypertrophic cardiomyopathyCoronary artery diseaseLong-term survivalClass ITract gradientEarly surgeryArtery diseaseHypertrophic cardiomyopathyLeft ventricular outflow tract gradientAppropriate internal defibrillator dischargePrimary composite end pointBasal septal thicknessClass I indicationsPrimary composite eventsHypertrophic obstructive cardiomyopathyComposite end pointLong-term outcomesComposite eventsEarly referralObstructive cardiomyopathyExercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy
Fava A, Alashi A, Saijo Y, Mathias I, Popovic Z, Thamilarasan M, Lever H, Desai M. Exercise capacity is associated with rest and peak-exercise left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy. European Heart Journal 2020, 41: ehaa946.0081. DOI: 10.1093/ehjci/ehaa946.0081.Peer-Reviewed Original ResearchLV-GLSHypertrophic cardiomyopathyExercise capacityHCM patientsVentricular global longitudinal strainGlobal myocardial strainSymptomatic HCM patientsReduced exercise capacitySubclinical cardiac dysfunctionSubclinical myocardial dysfunctionGlobal longitudinal strainLVOT gradientCardiac deteriorationExercise impairmentCardiac dysfunctionMyocardial dysfunctionMaximal exerciseExercise testExercise variablesClinical utilityFunctional capacityPatientsMyocardial strainLogistic regressionLongitudinal strainCLINICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: RELATIONSHIP TO LV GLOBAL LONGITUDINAL STRAIN
Klein J, Alashi A, Svensson L, Komarlu R, Saarel E, Aziz P, Najm H, Lever H, Zahka K, Desai M. CLINICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: RELATIONSHIP TO LV GLOBAL LONGITUDINAL STRAIN. Journal Of The American College Of Cardiology 2020, 75: 621. DOI: 10.1016/s0735-1097(20)31248-1.Peer-Reviewed Original Research
2019
Different Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy
Alashi A, Desai RM, Khullar T, Hodges K, Rodriguez ER, Tan C, Popovic ZB, Thamilarasan M, Wierup P, Lever HM, Smedira NG, Desai MY. Different Histopathologic Diagnoses in Patients With Clinically Diagnosed Hypertrophic Cardiomyopathy After Surgical Myectomy. Circulation 2019, 140: 344-346. PMID: 31329486, DOI: 10.1161/circulationaha.119.040129.Peer-Reviewed Original ResearchCHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE
Alashi A, Svensson L, Klein J, Zahka K, Smedira N, Najm H, Stewart R, Lever H, Aziz P, Saarel E, Desai M. CHARACTERISTICS AND LONGER-TERM OUTCOMES OF PEDIATRIC PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE. Journal Of The American College Of Cardiology 2019, 73: 878. DOI: 10.1016/s0735-1097(19)31485-8.Peer-Reviewed Original ResearchTertiary care center experienceLong-term outcomesCenter experiencePediatric patientsHypertrophic cardiomyopathyPatientsCardiomyopathy