2024
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
Jadam S, Gaballa A, Alashi A, Xu B, Thamilarasan M, Rodriguez E, Tan C, Ospina S, Smedira N, Popovic Z, Desai M. Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Failure 2024 PMID: 39545888, DOI: 10.1016/j.jchf.2024.10.006.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathySurgical myectomyLong-term outcomesMyocyte hypertrophyInterstitial fibrosisHistological findingsHypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathy patientsHistological scoresAssociated with long-term outcomesSevere histological findingsHypertrophic cardiomyopathy patientsKaplan-Meier analysisMultivariate Cox analysisLeft ventricular hypertrophyComposite of deathPrimary eventDiastolic dysfunctionCardiac transplantationPrimary endpointTertiary centerCardiomyopathy patientsMicrovascular ischemiaVentricular hypertrophyCox analysisDiastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Fava A, Popovic Z, Alashi A, Thamilarasan M, Xu B, Desai M. Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity. The American Journal Of Cardiology 2024, 232: 34-40. PMID: 39307332, DOI: 10.1016/j.amjcard.2024.09.017.Peer-Reviewed Original ResearchTreadmill exercise echocardiographyHypertrophic cardiomyopathyCongestive heart failureDiastolic parametersExercise capacityStress echocardiographyAssociated with reduced exercise capacityPrecipitate congestive heart failureLeft ventricular (LVAsymptomatic/minimally symptomatic patientsDiastolic stress echocardiographyMultivariate logistic regression analysisSymptomatic HCM patientsEtiology of dyspneaHigher body mass indexBody mass indexReduced exercise capacityExercise functional capacityLogistic regression analysisAssociated with <Incremental diagnostic utilityHigher LAViLVOT gradientE/e' ratioDiastolic dysfunction
2020
Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity
Fava A, Mathias I, Alashi A, Saijo Y, Popovic Z, Thamilarasan M, Lever H, Desai M. Diastolic stress test echocardiography in patients with hypertrophy cardiomyopathy: association with exercise capacity. European Heart Journal 2020, 41: ehaa946.2087. DOI: 10.1093/ehjci/ehaa946.2087.Peer-Reviewed Original ResearchDiastolic dysfunctionExercise capacityLVOT gradientMaximal exerciseHCM patientsLate mitral inflow velocityLateral mitral annular velocityMitral E/eAbnormal diastolic responseSymptomatic HCM patientsAtrial volume indexReduced exercise capacityVentricular filling pressureMitral annular velocityMitral inflow velocityHypertrophic cardiomyopathy patientsLogistic regression analysisHypertrophy cardiomyopathyDiastolic responseMetabolic equivalentsCardiomyopathy patientsAnnular velocityFilling pressureFunctional capacityPatients