2020
All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDose
2019
High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans.
Banerjee G, Edelman EJ, Barry DT, Crystal S, Gordon KS, Gordon AJ, Gaither JR, Green TC, Kerns RD, Manhapra A, Moore BA, Fiellin DA, Marshall BDL. High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans. Pain 2019, 160: 2126-2135. PMID: 31145217, PMCID: PMC6699915, DOI: 10.1097/j.pain.0000000000001606.Peer-Reviewed Original ResearchConceptsHigh-dose opioid prescriptionsOpioid prescriptionsHeroin useCohort studyPrior receiptHepatitis C virus (HCV) infection statusLong-term opioid prescriptionsPast-year heroin useVeterans Aging Cohort StudyHigh-dose opioidsOpioid-prescribing patternsProspective cohort studyAging Cohort StudyOpioid use disorderCurrent national guidelinesUnhealthy alcohol useUnited States veteransUnited States military veteransVirus infection statusPosttraumatic stress disorderOpioid receiptPrescribed opioidsPain interferenceCox regressionStates veterans
2001
Underutilization of reperfusion therapy in eligible African Americans with acute myocardial infarction: Role of presentation and evaluation characteristics
Manhapra A, Canto J, Barron H, Malmgren J, Taylor H, Rogers W, Weaver W, Every N, Borzak S. Underutilization of reperfusion therapy in eligible African Americans with acute myocardial infarction: Role of presentation and evaluation characteristics. American Heart Journal 2001, 142: 604-610. PMID: 11579349, DOI: 10.1067/mhj.2001.118464.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAngioplastyBlack or African AmericanComorbidityCoronary Artery BypassFemaleHeart FailureHospitalizationHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial ReperfusionPatient SelectionProspective StudiesRegistriesStrokeThrombolytic TherapyTime FactorsTreatment OutcomeConceptsAcute myocardial infarctionReperfusion therapyMyocardial infarctionAfrican AmericansImmediate reperfusion therapyMyocardial Infarction 2Early reperfusion therapyCongestive heart failureCoronary blood flowDefinite myocardial infarctionAfrican American patientsEligible patientsPrior strokeChest painHospital arrivalInitial admissionRate of useAtypical presentationEarly reperfusionHeart failureMean ageAmerican patientsNational registryCare providersBlood flow