2008
Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function
Maung AA, Fujimi S, MacConmara MP, Tajima G, McKenna AM, Delisle AJ, Stallwood C, Onderdonk AB, Mannick JA, Lederer JA. Injury Enhances Resistance to Escherichia coli Infection by Boosting Innate Immune System Function. The Journal Of Immunology 2008, 180: 2450-2458. PMID: 18250454, DOI: 10.4049/jimmunol.180.4.2450.Peer-Reviewed Original ResearchConceptsBurn-injured miceSham miceCecal ligationEnhanced innate immune responseSystemic inflammatory response syndromeInnate immune system functionRelevant sepsis modelSham-injured miceInflammatory response syndromeMac-1 expressionEscherichia coli infectionInnate immune responseSite of infectionImmune system functionPolymicrobial sepsisResponse syndromeOpportunistic infectionsSepsis modelDays postinjuryInjury causesColi infectionImmune responseCommon pathogensMajor injuriesAnimal studies
2006
Platelet depletion in mice increases mortality after thermal injury
Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood 2006, 107: 4399-4406. PMID: 16467203, PMCID: PMC1895793, DOI: 10.1182/blood-2005-09-3776.Peer-Reviewed Original ResearchConceptsControl miceFull-thickness total body surface areaHost responseThermal injuryTotal body surface areaExperimental control miceSystemic inflammatory responsePlatelet-depleted miceRole of plateletsBody surface areaCause of deathCritical protective rolePeripheral blood monocytesImportance of plateletsSham injuryIL-6MCP-1Plasma levelsPlatelet depletionInflammatory responseImmune responseAdaptive immunityBlood monocytesMouse modelProtective role
2005
Enhanced TLR4 reactivity following injury is mediated by increased p38 activation
Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal Of Leukocyte Biology 2005, 78: 565-573. PMID: 15857937, DOI: 10.1189/jlb.1204698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBurnsCells, CulturedEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationImidazolesLipopolysaccharidesMacrophagesMaleMembrane GlycoproteinsMiceMyoD ProteinProtein KinasesPyridinesReceptors, Cell SurfaceSignal TransductionSpleenToll-Like Receptor 4Toll-Like ReceptorsConceptsMitogen-activated protein kinaseExtracellular signal-regulated kinaseStress-activated protein kinaseP38 activationJun N-terminal kinase (JNK) mitogen-activated protein kinaseProtein kinaseKinase mitogen-activated protein kinaseSAPK/JNK activationProtein-2 proteinTLR4 reactivitySham miceSpecific p38 inhibitorSignal-regulated kinaseInterleukin-1 receptor-associated kinaseDay 1Receptor-associated kinaseMyeloid differentiation primary response protein 88Tumor necrosis factor-alpha productionToll-like receptor 4Necrosis factor-alpha productionCell surface expressionTLR4 mRNA expressionInjury-induced increaseProinflammatory cytokine productionInjury-induced changes
1998
Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy.
Shaw S, Maung A, Steptoe R, Thomson A, Vujanovic3 N. Expansion of functional NK cells in multiple tissue compartments of mice treated with Flt3-ligand: implications for anti-cancer and anti-viral therapy. The Journal Of Immunology 1998, 161: 2817-24. PMID: 9743341, DOI: 10.4049/jimmunol.161.6.2817.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntineoplastic AgentsAntiviral AgentsCell DifferentiationCytotoxicity, ImmunologicDendritic CellsDose-Response Relationship, ImmunologicHematopoiesisHumansInjections, IntraperitonealInterleukin-2Killer Cells, NaturalKineticsLigandsLymphocyte ActivationLymphocyte CountMembrane ProteinsMiceMice, Inbred C57BLOrgan SpecificityPeptidesT-Lymphocyte SubsetsConceptsNK cellsIL-2Lymphokine-activated killer activityAdherent NK cellsAdministration of Flt3Dendritic cell productionFlt3-L treatmentFunctional NK cellsRecombinant human Flt3 ligandMature NK cellsNK cell developmentNK cell generationNK cell progenitorsAnti-viral therapyCell proliferative responsesTotal cytotoxic activityNK activityTime-dependent increaseDaily i.Multiple tissue compartmentsKiller activityHuman Flt3 ligandProliferative responseVivo effectsViral infection