2024
Anticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis
Yaghi S, Shu L, Fletcher L, Fayad F, Shah A, Herning A, Isho N, Mansour P, Joudi K, Zaidat B, Mahmoud N, Khalek F, Xiao H, Goldstein E, Ghannam M, Siegler J, Omran S, Bakradze E, Nguyen T, Keser Z, Khan M, Shahripour R, de Havenon A, Henninger N, Heldner M, Field T, Aziz Y, Mistry E, Furie K, Engelter S, Markus H. Anticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis. Stroke 2024, 55: 1776-1786. PMID: 38847098, DOI: 10.1161/strokeaha.124.047310.Peer-Reviewed Original ResearchConceptsCervical artery dissectionSystematic reviewArtery dissectionMeta-analysisBleeding riskIschemic stroke riskAntiplatelet therapyRandomized trialsSpontaneous cervical artery dissectionRisk of deathIschemic strokeCombination of keywordsTreated with antiplateletSafety of dual antiplatelet therapyReducing ischemic strokeSymptomatic intracranial hemorrhageOptimal antithrombotic strategyMajor traumaDual antiplatelet therapyIndividualized therapeutic approachStudy of patientsInclusion criteriaRandomized clinical trialsMeta-analysesEffect sizeImpaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies
Sharma R, de Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies. BMJ Neurology Open 2024, 6: e000501. PMID: 38288313, PMCID: PMC10823923, DOI: 10.1136/bmjno-2023-000501.Peer-Reviewed Original ResearchVascular brain injurySlow walkingAtherosclerosis RiskMobility impairmentsAssociated with mobility impairmentImpaired mobilityUK Biobank (UKBStroke-free cohortMarkers of vascular brain injuryAdjusted multivariate logistic regression analysisGait dataMultivariate logistic regression analysisCommunity-dwellingLogistic regression analysisBrain injuryARICUKBInclusion criteriaStudy cohortWalkingClinical strokeRegression analysisImpaired outcomeMRI markersStudy background
2023
RESCUE‐ICAS: Rationale and Study Design
Almallouhi E, de Havenon A, Asi K, Limaye K, Maier I, Starke R, Psychogios M, Inoa V, Grossberg J, Mascitelli J, Samaniego E, Fragata I, Kass‐Hout T, Capasso F, Dmytriw A, Jehani H, Modovan K, Yaghi S, Ezzeldin M, Grandhi R, Wolfe S, Fargen K, Jabbour P, Naamani K, Spiotta A, Zaidat O, Kasab S. RESCUE‐ICAS: Rationale and Study Design. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.122.000530.Peer-Reviewed Original ResearchICAS-LVORescue therapyIntracranial stenosisCerebral Infarction scoreMechanical thrombectomy failureSymptomatic intracranial hemorrhageProspective cohort studyLarge vessel occlusionRankin Scale scoreOptimal treatment strategyThrombectomy failureProspective registrySuccessful recanalizationCohort studyModified thrombolysisAtherosclerotic diseaseIntracranial hemorrhageTreatment strategiesCommon causeInclusion criteriaRadiographic dataImaging variablesScale scoreMT casesPatientsBorderzone Infarcts and Recurrent Cerebrovascular Events in Symptomatic Intracranial Arterial Stenosis: A Systematic Review and Meta-Analysis
Das S, Shu L, Morgan R, Shah A, Fayad F, Goldstein E, Chahien D, Maglinger B, Bokka S, Owens C, Abbasi M, Kvernland A, Siegler J, Mac Grory B, Nguyen T, Furie K, Khatri P, Mistry E, Prabhakaran S, Liebeskind D, Romano J, de Havenon A, Palaiodimou L, Tsivgoulis G, Yaghi S. Borderzone Infarcts and Recurrent Cerebrovascular Events in Symptomatic Intracranial Arterial Stenosis: A Systematic Review and Meta-Analysis. Journal Of Stroke 2023, 25: 223-232. PMID: 37282372, PMCID: PMC10250880, DOI: 10.5853/jos.2023.00185.Peer-Reviewed Original ResearchBorderzone infarctsIntracranial arterial stenosisRisk ratioNeurological deteriorationSystematic reviewRecurrent strokeInfarct patternsArterial stenosisAnterior circulation stroke patientsSymptomatic intracranial arterial stenosisRecurrent cerebrovascular eventsPosterior circulation strokeSymptomatic ICACerebrovascular eventsStroke recurrenceTerritorial infarctsDistal perfusionRecurrence rateStroke patientsSubgroup analysisThrombus embolizationOutcome eventsPlaque progressionInclusion criteriaHigh riskRecurrence risk in symptomatic intracranial stenosis treated medically in the real world
Yaghi S, Shu L, Goldstein E, Chang A, Kala N, Stretz C, Burton T, Perelstein E, Furie K, Jayaraman M, Torabi R, Moldovan K, de Havenon A, Khatri P, Gebregziabher M, Liebeskind D, Prabhakaran S. Recurrence risk in symptomatic intracranial stenosis treated medically in the real world. Journal Of Stroke And Cerebrovascular Diseases 2023, 32: 107086. PMID: 37030126, DOI: 10.1016/j.jstrokecerebrovasdis.2023.107086.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisSymptomatic intracranial atherosclerotic stenosisClinical trialsRecurrence riskRecurrent strokeInclusion criteriaReal-world settingMaximal medical treatmentRecurrent stroke rateDual antiplatelet therapyAcute ischemic strokeReal-world cohortSymptomatic intracranial stenosisPharmacological treatment strategiesCox regression modelMeeting inclusion criteriaLow event ratesAntiplatelet therapyStroke RegistryIschemic eventsIschemic strokeWorld CohortHospitalized patientsEarly recurrenceIntracranial stenosis
2022
Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis
Yaghi S, Saldanha IJ, Misquith C, Zaidat B, Shah A, Joudi K, Persaud B, Khalek F, Shu L, de Havenon A, Mistry EA, Bakradze E, Goldstein ED, Reagan J, Theodorou A, Palaiodimou L, Furie K, Field TS, Tsivgoulis G, Mac Grory B. Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis. Stroke 2022, 53: 3014-3024. PMID: 35938419, DOI: 10.1161/strokeaha.122.039579.Peer-Reviewed Original ResearchConceptsCerebral venous thrombosisDirect oral anticoagulantsVitamin K antagonistsVenous thrombosisK antagonistsSystematic reviewRelative riskObservational studyDirect Oral Anticoagulants Versus Vitamin K AntagonistsSafety of DOACsVitamin K antagonist treatmentRecurrent venous thromboembolismHigh-level evidenceLeast moderate riskVenous recanalizationOral anticoagulantsVenous thromboembolismMajor hemorrhageMore patientsAntagonist treatmentIntracranial hemorrhageCombination of keywordsComparable efficacyInclusion criteriaSafety outcomes
2021
Carotid Stenosis and Recurrent Ischemic Stroke
Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke. Stroke 2021, 52: 2414-2417. PMID: 33940954, PMCID: PMC8268075, DOI: 10.1161/strokeaha.121.034089.Peer-Reviewed Original ResearchConceptsHigh-risk transient ischemic attackTransient ischemic attackEffect of clopidogrelMinor ischemic strokeIschemic strokeIschemic stroke riskCarotid stenosisIschemic attackStroke riskCervical internal carotid arteryAddition of clopidogrelDual antiplatelet therapyRecurrent ischemic strokeCox regression modelInternal carotid arteryAntiplatelet therapyPrimary outcomePoint trialCarotid arteryInclusion criteriaClopidogrelAdjusted modelStenosisPatientsStrokeImpaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volume
2020
Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 "
Taussky P, Agnoletto G, Grandhi R, Alexander MD, Wong KH, Albers GW, de Havenon A. Prediction of death after endovascular thrombectomy in the extended window: a secondary analysis of DEFUSE 3 ". Journal Of NeuroInterventional Surgery 2020, 13: 805-808. PMID: 33077580, PMCID: PMC8093992, DOI: 10.1136/neurintsurg-2020-016548.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyDEFUSE 3Statin usePrimary outcomeInclusion criteriaPredictive scoreHealth Stroke Scale scoreDEFUSE 3 studyEVT-treated patientsSecondary cohort analysisBaseline National InstitutesStroke Scale scoreHistory of diabetesPrediction of deathSelective inclusion criteriaUnivariate regression analysisHigh-risk categoryPotential predictive variablesEVT patientsPatient ageEndovascular therapyImaging evaluationPreprocedural variablesClinical trialsLethal outcomeAnticoagulation Type and Early Recurrence in Cardioembolic Stroke
Yaghi S, Mistry E, Liberman AL, Giles J, Asad SD, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Lord A, Furie K, Keyrouz S, Nouh A, Leon Guerrero CR, de Havenon A, Khan M, Henninger N. Anticoagulation Type and Early Recurrence in Cardioembolic Stroke. Stroke 2020, 51: 2724-2732. PMID: 32757753, PMCID: PMC7484360, DOI: 10.1161/strokeaha.120.028867.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsAtrial FibrillationBrain IschemiaEmbolismFemaleHeart DiseasesHeparin, Low-Molecular-WeightHumansIncidenceIntracranial HemorrhagesMaleMiddle AgedNeuroimagingRecurrenceRegistriesRetrospective StudiesRisk AssessmentStrokeTreatment OutcomeUnited StatesWarfarinConceptsSymptomatic intracranial hemorrhageRecurrent ischemic eventsLow molecular weight heparinAcute ischemic strokeMolecular weight heparinIschemic eventsIntracranial hemorrhageIschemic strokeAtrial fibrillationAnalysis inclusion criteriaEarly recurrenceWeight heparinInclusion criteriaSeparate Cox regression analysesComprehensive stroke centerLarge prospective studiesOral anticoagulant therapyCox regression analysisCox regression modelAnticoagulation typeDOAC treatmentStroke RegistryAnticoagulant therapyCardioembolic strokeStroke centersHypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke
de Havenon A, Khatri P, Prabhakaran S, Yeatts S, Peterson C, Sacchetti D, Alexander M, Cutting S, Mac Grory B, Furie K, Liebeskind D, Yaghi S. Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke. Journal Of Neuroimaging 2020, 30: 468-470. PMID: 32579278, PMCID: PMC8010594, DOI: 10.1111/jon.12710.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseSymptomatic intracranial atherosclerotic diseaseDistal hypoperfusionRecurrent strokeComputed tomographyRetrospective study of patientsImpaired distal flowIntracranial atherosclerotic disease patientsSymptomatic ischemic strokeStudy of patientsAssociated with recurrent strokeMiddle cerebral arteryAssociated with stroke recurrenceIntracranial carotidSecondary stroke preventionRetrospective studySymptomatic arteryPerfusion statusHazard ratioPrimary outcomeCerebral arteryStroke preventionHypoperfusionPatientsInclusion criteria
2019
Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis
Alexander MD, de Havenon A, Kim SE, Parker DL, McNally JS. Assessment of quantitative methods for enhancement measurement on vessel wall magnetic resonance imaging evaluation of intracranial atherosclerosis. Neuroradiology 2019, 61: 643-650. PMID: 30675639, PMCID: PMC8022353, DOI: 10.1007/s00234-019-02167-3.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic diseaseVessel wall magnetic resonance imagingInter-rater agreementLower infundibulumHigh inter-rater agreementVessel wall magnetic resonanceGood inter-rater agreementPost-contrast imagingPresence of enhancementMagnetic resonance imagingPost-contrast imagesRatio of enhancementCulprit lesionIntracranial atherosclerosisAtherosclerotic diseaseInclusion criteriaBlinded reviewersResonance imagingLesion enhancementHigh agreementPlaque signalLesionsInfundibulumObjective dataMagnetic resonance
2018
Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest
Peckham ME, Anderson JS, Rassner UA, Shah LM, Hinckley PJ, de Havenon A, Kim SE, McNally JS. Low b-value diffusion weighted imaging is promising in the diagnosis of brain death and hypoxic-ischemic injury secondary to cardiopulmonary arrest. Critical Care 2018, 22: 165. PMID: 29925413, PMCID: PMC6011248, DOI: 10.1186/s13054-018-2087-9.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyBrain deathGlobal hypoperfusionNormal subjectsDiagnosis of HIEHypoxic-ischemic brain injuryMatter regionsHypoxic-ischemic injuryIschemic brain injurySex-matched controlsLow b-value DWIApparent diffusion coefficient (ADC) valuesGray matter regionsWhite matter regionsWhite matter valuesIschemic encephalopathyDelayed DiagnosisArrest patientsCardiopulmonary arrestCardiorespiratory arrestBrain injuryInclusion criteriaBD subjectsOrgan donorsGray matter
2017
Validation of the unruptured intracranial aneurysm treatment score: comparison with real-world cerebrovascular practice.
Ravindra VM, de Havenon A, Gooldy TC, Scoville J, Guan J, Couldwell WT, Taussky P, MacDonald JD, Schmidt RH, Park MS. Validation of the unruptured intracranial aneurysm treatment score: comparison with real-world cerebrovascular practice. Journal Of Neurosurgery 2017, 129: 100-106. PMID: 28984518, DOI: 10.3171/2017.4.jns17548.Peer-Reviewed Original ResearchConceptsUnruptured intracranial aneurysmsTreatment recommendationsUnruptured Intracranial Aneurysm Treatment ScoreReal-world treatment decisionsQuaternary academic medical centerPercentage of misclassificationReal-world cohortAcademic medical centerConsecutive patientsConservative managementCerebrovascular specialistsUIATSTreatment decisionsInclusion criteriaMedical CenterTreatment scoresPatientsRupture rateIntracranial aneurysmsScreening toolROC curveReal-world experienceCharacteristic curveTreatmentFurther validationCarotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis
de Havenon A, Tirschwell D, Majersik JJ, McNally S, Stoddard G, Moore A, Mossa-Basha M. Carotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis. The Neuroradiology Journal 2017, 30: 486-489. PMID: 28631982, PMCID: PMC5602332, DOI: 10.1177/1971400917707351.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeSymptomatic carotid atherosclerosisCarotid atherosclerosisMicroembolic signalsIntraplaque hemorrhageCarotid intraplaque hemorrhageTranscranial DopplerVessel wall MRIIschemic strokeEmboli monitoringPresence of IPHRecent acute ischemic strokeTransient ischemic attackWarrants prospective studiesAcute stroke patientsRetrospective chart reviewRisk of strokeIschemic attackChart reviewProspective studyStroke patientsResults TwentyInclusion criteriaLarge cohortVolumetric MRI