2022
Mutation of breast cancer susceptibility genes increases cerebral microbleeds: A pilot study
Pope B, Wolcott Z, Castillo M, Jin J, Wong KH, Havenon A, Yaghi S, Goldstein ED. Mutation of breast cancer susceptibility genes increases cerebral microbleeds: A pilot study. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106729. PMID: 36116220, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106729.Peer-Reviewed Original ResearchConceptsCerebral small vessel diseaseCerebrovascular risk factorsBRCA mutationsCerebral microbleedsRisk factorsOdds ratioMarkers of CSVDBreast cancer susceptibility gene mutationsRetrospective cross-sectional analysisCancer susceptibility gene mutationsAdjusted odds ratioSmall vessel diseaseHosmer-Lemeshow testSusceptibility gene mutationsCross-sectional analysisLogistic regression modelsBreast cancer susceptibility genesVessel diseaseWildtype individualsBrain MRICancer susceptibility genesStudent's t-test analysisT-test analysisMalignancy evaluationClinical implicationsStatin Usage Increases White Matter Hyperintensities
Goldstein ED, Garg G, Navarro K, Wolcott Z, Yaghi S, Wong KH, McLean K, de Havenon AH. Statin Usage Increases White Matter Hyperintensities. The Neurologist 2022, 28: 94-98. PMID: 35680399, DOI: 10.1097/nrl.0000000000000448.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesWMH progressionStatin usageTop tertileRisk factorsMatter hyperintensitiesWMH volumeConventional cerebrovascular risk factorsProgression of WMHCerebral small vessel diseaseInfluence of dyslipidemiaCerebrovascular risk factorsInfluence of statinsBaseline WMH volumeSmall vessel diseaseSynergistic risk factorsLow-density lipoproteinFull therapyStatin useVessel diseaseStudy visitWMH developmentPartial therapyWMH dataReductase inhibitors
2021
Lacunar stroke: mechanisms and therapeutic implications
Yaghi S, Raz E, Yang D, Cutting S, Mac Grory B, Elkind MS, de Havenon A. Lacunar stroke: mechanisms and therapeutic implications. Journal Of Neurology Neurosurgery & Psychiatry 2021, 92: 823-830. PMID: 34039632, DOI: 10.1136/jnnp-2021-326308.Peer-Reviewed Original ResearchLacunar strokeNeurological deteriorationTreatment strategiesTherapeutic implicationsCerebral small vessel diseaseLacunar stroke patientsStroke prevention strategiesAntithrombotic treatment strategiesLong-term disabilitySmall vessel diseaseNovel treatment strategiesAtheromatous diseaseIschemic strokeStroke patientsVessel diseaseNeurovascular imagingStroke mechanismHeterogeneous diseaseSystemic evaluationPrevention strategiesNarrative reviewStrokePatientsDiseaseUnderlying mechanismThe association between transthoracic echocardiogram parameters and white matter hyperintensities
Navarro KS, Wong KH, Ibrahim MM, de Havenon AH, Goldstein ED. The association between transthoracic echocardiogram parameters and white matter hyperintensities. Clinical Neurology And Neurosurgery 2021, 206: 106672. PMID: 33979694, DOI: 10.1016/j.clineuro.2021.106672.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBrain magnetic resonance imagingCerebral small vessel diseaseVentricular ejection fractionCardiac chamber sizeTransthoracic echocardiogramFazekas scoreEjection fractionAtrial areaTricuspid annular plane systolic excursionAnnular plane systolic excursionRight ventricular ejection fractionRight ventricular internal diameterRetrospective chart reviewRight atrial areaSmall vessel diseaseVentricular internal diameterMultivariate ordinal logistic regression modelWhite matter hyperintensitiesChamber sizeLogistic regression modelsOrdinal logistic regression modelsMore WMHChart reviewSystolic excursion