2023
Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis
Palaiodimou L, Joundi R, Katsanos A, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Malhotra K, Spiotta A, Vassilopoulou S, Tsioufis K, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis. European Stroke Journal 2023, 9: 88-96. PMID: 37921233, PMCID: PMC10916831, DOI: 10.1177/23969873231211157.Peer-Reviewed Original ResearchBlood pressure variabilitySymptomatic intracranial hemorrhageAcute ischemic strokeEndovascular thrombectomyFunctional impairmentIschemic strokeHighest tertileAIS patientsPressure variabilityIndividual BP measurementsMean BP levelsDiastolic BP levelsIndividual patient dataLogistic mixed-effects modelsSBP-CVSBP-SDIntravenous thrombolysisStroke outcomeStroke severitySuccessful recanalizationBP levelsIntracranial hemorrhageBP measurementsHigh mortalityTertileRates and reasons for hospital readmission after acute ischemic stroke in a US population-based cohort
Zhou L, Lansberg M, de Havenon A. Rates and reasons for hospital readmission after acute ischemic stroke in a US population-based cohort. PLOS ONE 2023, 18: e0289640. PMID: 37535655, PMCID: PMC10399731, DOI: 10.1371/journal.pone.0289640.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeAcute renal failureHospital readmissionIschemic strokeReadmission ratesRenal failureRisk factorsUS population-based cohortUnplanned hospital readmissionNationwide Readmissions DatabaseRisk of readmissionVascular risk factorsHospital-level characteristicsPopulation-based cohortKaplan-Meyer analysisWorsened patient outcomesState administrative databasesModifiable comorbiditiesRecurrent strokeInitial hospitalizationDisadvantaged patientsLonger initial lengthMedicare insuranceAIS patientsSecondary stroke
2022
Direct cost analysis of rapid MRI in the emergency department evaluation of patients suspected of having acute ischemic stroke**
de Havenon A, Orlando C, Delic A, McNally JS, Majersik JJ, Harman T, Alexander M, Reddy V, Lyden S, Anzai Y. Direct cost analysis of rapid MRI in the emergency department evaluation of patients suspected of having acute ischemic stroke**. The Neuroradiology Journal 2022, 36: 142-147. PMID: 35701745, PMCID: PMC10034695, DOI: 10.1177/19714009221108681.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHospital lengthIschemic strokeBrain attackRapid MRIAIS patientsEmergency departmentCT perfusionMRI cohortRapid MRI protocolTotal hospital lengthEmergency department evaluationDirect costsNeurologic symptom onsetTotal direct costsDirect cost analysisHospital LOSSequential patientsSymptom onsetDepartment evaluationED LOSPrimary outcomeDischarge diagnosisPatientsMRI protocol
2021
Investigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke
Grandhi R, Ravindra VM, Ney JP, Zaidat O, Taussky P, de Havenon A. Investigating the “Weekend Effect” on Outcomes of Patients Undergoing Endovascular Mechanical Thrombectomy for Ischemic Stroke. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 106013. PMID: 34375859, PMCID: PMC8511062, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106013.Peer-Reviewed Original ResearchMeSH KeywordsAfter-Hours CareAgedAged, 80 and overCross-Sectional StudiesDatabases, FactualEndovascular ProceduresFemaleHospital CostsHospital MortalityHumansInpatientsIschemic StrokeLength of StayMaleMiddle AgedPatient DischargeRetrospective StudiesRisk AssessmentRisk FactorsThrombectomyTime FactorsTreatment OutcomeUnited StatesConceptsAcute ischemic strokeEndovascular thrombectomyIschemic strokeLarge vessel occlusion ischemic strokeHealth Stroke Scale scoreNationwide Inpatient Sample dataStroke Scale scoreExtended hospital stayWorse clinical outcomesCross-sectional analysisLogistic regression modelsHospital deathHospital staySecondary outcomesPrimary outcomeClinical outcomesAIS patientsNormal working hoursPatientsScale scoreFavorable dischargeExposure variablesStrokeWeekends/National Institute
2020
Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes
de Havenon A, Yaghi S, Mistry EA, Delic A, Hohmann S, Shippey E, Stulberg E, Tirschwell D, Frontera JA, Petersen NH, Anadani M. Endovascular thrombectomy in acute ischemic stroke patients with COVID-19: prevalence, demographics, and outcomes. Journal Of NeuroInterventional Surgery 2020, 12: 1045-1048. PMID: 32989032, PMCID: PMC7523171, DOI: 10.1136/neurintsurg-2020-016777.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overBrain IschemiaComorbidityCoronavirus InfectionsCOVID-19Endovascular ProceduresEthnicityFemaleHospital MortalityHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSex FactorsSocioeconomic FactorsStrokeStroke RehabilitationThrombectomyTreatment OutcomeYoung AdultConceptsCOVID-19 infectionAcute ischemic stroke patientsEndovascular thrombectomyIschemic stroke patientsHospital deathAIS patientsEVT patientsFavorable dischargeStroke patientsLower oddsCOVID-19Intensive care unit lengthLaboratory-confirmed COVID-19Vizient Clinical Data BaseComorbid COVID-19Acute coronary syndromeAcute renal failurePotential adverse eventsICD-10 codesMixed-effects logistic regressionClinical data baseCoronary syndromeLonger hospitalSystemic complicationsAdverse eventsAcute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic
Agarwal S, Scher E, Rossan-Raghunath N, Marolia D, Butnar M, Torres J, Zhang C, Kim S, Sanger M, Humbert K, Tanweer O, Shapiro M, Raz E, Nossek E, Nelson PK, Riina HA, de Havenon A, Wachs M, Farkas J, Tiwari A, Arcot K, Parella DT, Liff J, Wu T, Wittman I, Caldwell R, Frontera J, Lord A, Ishida K, Yaghi S. Acute stroke care in a New York City comprehensive stroke center during the COVID-19 pandemic. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 105068. PMID: 32807471, PMCID: PMC7305900, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBetacoronavirusComprehensive Health CareCoronavirus InfectionsCOVID-19Critical PathwaysDelivery of Health Care, IntegratedFemaleHumansMaleMiddle AgedNew York CityPandemicsPatient Care TeamPneumonia, ViralQuality ImprovementQuality Indicators, Health CareRegistriesRetrospective StudiesSARS-CoV-2StrokeThrombectomyThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeWorkflowConceptsComprehensive stroke centerAcute ischemic strokePre-pandemic groupAIS patientsStroke centersTransient ischemic attack/strokeAcute stroke processDefect-free careLonger median doorEmergency health care servicesAcute stroke careConsecutive AIS patientsQuality improvement registrySuccessful recanalization rateLong-term outcomesQuality of careHealth care servicesCOVID-19 screeningAcute strokeIschemic strokeLonger doorMechanical thrombectomyMedian doorStroke severityDischarge outcomes
2015
Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System
Chung LS, Tkach A, Lingenfelter EM, Dehoney SB, Rollo J, de Havenon A, DeWitt LD, Grantz MR, Wang H, Wold JJ, Hannon PM, Weathered NR, Majersik JJ. Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 565-571. PMID: 26698642, PMCID: PMC4779727, DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.014.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerRegional stroke systemAcute ischemic strokeCommunity hospitalAdministration errorsStroke systemsWeight-based dosingMean age 68Ischemic strokeStroke centersStroke outcomeAIS patientsCH patientsAge 68Infusion rateSystemic hemorrhageAIS casesBody weightPharmacy informationPatientsIncorrect dosageOutcomesPrescriptionTPAAssociation