Rubia Isler Mancuso
Associate Research Scientist in Laboratory MedicineAbout
Research
Publications
2025
Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial
de Melo Campos P, Pagnano K, Niemann F, Mancuso R, Della Via F, Congrains A, Coelho‐Silva J, Tinoco Â, Assis‐Mendonça G, de Freitas L, Traina F, Saad S. Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial. Hematological Oncology 2025, 44: e70163. PMID: 41456173, PMCID: PMC12744688, DOI: 10.1002/hon.70163.Peer-Reviewed Original ResearchImpaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
Xu P, Mancuso R, Leonzino M, Zeiss C, Krause D, De Camilli P. Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C. PLOS Biology 2025, 23: e3003393. PMID: 40956846, PMCID: PMC12463328, DOI: 10.1371/journal.pbio.3003393.Peer-Reviewed Original Research
2024
CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors
Kwon N, Lu Y, Thompson E, Mancuso R, Wang L, Zhang P, Krause D. CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors. Blood 2024, 144: 1800-1812. PMID: 39102635, PMCID: PMC11530366, DOI: 10.1182/blood.2024023963.Peer-Reviewed Original ResearchThis study demonstrates that CDK9 phosphorylation of RUNX1 in human progenitors directs cell fate toward the megakaryocytic lineage and platelet production while reducing red blood cell formation.Aplastic anemia in association with multiple myeloma: clinical and pathophysiological insights
Muradashvili T, Liu Y, VanOudenhove J, Gu S, Krause D, Montanari F, Carlino M, Mancuso R, Stempel J, Halene S, Zeidan A, Podoltsev N, Neparidze N. Aplastic anemia in association with multiple myeloma: clinical and pathophysiological insights. Leukemia & Lymphoma 2024, 65: 2182-2189. PMID: 39225418, PMCID: PMC13192466, DOI: 10.1080/10428194.2024.2393260.Peer-Reviewed Original Research
2022
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.
Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.Peer-Reviewed Original ResearchStructure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization
Reed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.Peer-Reviewed Original ResearchRac GTPases in acute myeloid leukemia cells: Expression profile and biological effects of pharmacological inhibition
Ramos D, Mancuso R, Contieri B, Duarte A, Paiva L, de Melo Carrilho J, Saad S, Lazarini M. Rac GTPases in acute myeloid leukemia cells: Expression profile and biological effects of pharmacological inhibition. Toxicology And Applied Pharmacology 2022, 442: 115990. PMID: 35331739, DOI: 10.1016/j.taap.2022.115990.Peer-Reviewed Original ResearchGlioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression
Di Filippo L, Lobato Duarte J, Hofstätter Azambuja J, Isler Mancuso R, Tavares Luiz M, Hugo Sousa Araújo V, Delbone Figueiredo I, Barretto-de-Souza L, Miguel Sábio R, Sasso-Cerri E, Martins Baviera A, Crestani C, Teresinha Ollala Saad S, Chorilli M. Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression. International Journal Of Pharmaceutics 2022, 618: 121682. PMID: 35307470, DOI: 10.1016/j.ijpharm.2022.121682.Peer-Reviewed Original Research
2021
Protective effect of green tea and epigallocatechin-3-gallate in a LPS-induced systemic inflammation model
Azambuja J, Mancuso R, Via F, Torello C, Saad S. Protective effect of green tea and epigallocatechin-3-gallate in a LPS-induced systemic inflammation model. The Journal Of Nutritional Biochemistry 2021, 101: 108920. PMID: 34875388, DOI: 10.1016/j.jnutbio.2021.108920.Peer-Reviewed Original ResearchArtemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo
Mancuso R, Azambuja J, Niemann F, Congrains A, Foglio M, Rego E, Saad S. Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo. EJHaem 2021, 2: 818-822. PMID: 35845184, PMCID: PMC9175883, DOI: 10.1002/jha2.314.Peer-Reviewed Original Research