Mireille Serlie, MD, PhD
Cards
Appointments
Contact Info
Yale School of Medicine
300 Cedar Street
New Haven, CT 06519
United States
About
Titles
Professor of Internal Medicine (Endocrinology)
Biography
I am an endocrinologist and physician-scientist and joined Yale in 2023. My research delves into the intricate relationship between obesity, nutrition, and brain function in humans. My work is centered on two key areas: the neural mechanisms regulating food intake, with a particular focus on how nutrition and eating patterns influence brain responses, and the molecular and pathophysiological pathways driving insulin resistance within the context of obesity. In addition to my research, I am an expert in nutrition and serve as the Medical Director of the Amsterdam University Medical Center Expert Center for Intestinal Failure and Parenteral Nutrition.
Appointments
Endocrinology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Amsterdam (2007)
- Fellow
- Academic Medical Center Amsterdam (2005)
- Resident
- Academic Medical Center Amsterdam (2003)
- MD
- University of Amsterdam Medical School (1995)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Ralph DiLeone, PhD
Daniel F Vatner, MD, PhD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Varman Samuel, MD, PhD
Mario Kahn
Rafael Calais Gaspar, PhD, MSc
Publications
2025
The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies.
Slebe R, Splinter JJ, Schoonmade LJ, Blondin DP, Campbell DJT, Carpentier AC, Després JP, Hoeks J, Kalsbeek A, Raina P, Schrauwen P, Serlie MJ, Stenvers DJ, Yi CX, de Mutsert R, Beulens JWJ, Rutters F. The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies. Diabetes Obes Metab 2025, 27: 1172-1183. PMID: 39605179, DOI: 10.1111/dom.16104.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements[The treatment of intolerance for enteral nutrition of unknown origin with parenteral nutrition].
Korzilius JW, Dijkstra G, Keszthelyi D, van den Heuvel TJ, Serlie MJ, Wanten GJA. [The treatment of intolerance for enteral nutrition of unknown origin with parenteral nutrition]. Ned Tijdschr Geneeskd 2025, 169 PMID: 39976485.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Tissue-specific inflammation and insulin sensitivity in subjects with obesity.
Oussaada SM, Kilicarslan M, de Weijer BA, Gilijamse PW, Şekercan A, Virtue S, Janssen IMC, van de Laar A, Demirkiran A, van Wagensveld BA, Houdijk APJ, Jongejan A, Moerland PD, Verheij J, Geijtenbeek TB, Bloks VW, de Goffau MC, Romijn JA, Nieuwdorp M, Vidal-Puig A, Ter Horst KW, Serlie MJ. Tissue-specific inflammation and insulin sensitivity in subjects with obesity. Diabetes Res Clin Pract 2024, 111663. PMID: 38616042, DOI: 10.1016/j.diabres.2024.111663.Peer-Reviewed Original ResearchThe effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies.
Slebe R, Wenker E, Schoonmade LJ, Bouman EJ, Blondin DP, Campbell DJT, Carpentier AC, Hoeks J, Raina P, Schrauwen P, Serlie MJ, Jan Stenvers D, de Mutsert R, Beulens JWJ, Rutters F. The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies. Diabetes Res Clin Pract 2024, 210: 111638. PMID: 38548105, DOI: 10.1016/j.diabres.2024.111638.Peer-Reviewed Original ResearchThe science of micronutrients in clinical practice - Report on the ESPEN symposium.
Berger MM, Amrein K, Barazzoni R, Bindels L, Bretón I, Calder PC, Cappa S, Cuerda C, D'Amelio P, de Man A, Delzenne NM, Forbes A, Genton L, Gombart AF, Joly F, Laviano A, Matthys C, Phyo PP, Ravasco P, Serlie MJ, Shenkin A, Stoffel NU, Talwar D, van Zanten ARH. The science of micronutrients in clinical practice - Report on the ESPEN symposium. Clin Nutr 2024, 43: 268-283. PMID: 38104489, DOI: 10.1016/j.clnu.2023.12.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents.
Diepenbroek C, Rijnsburger M, van Irsen AAS, Eggels L, Kisner A, Foppen E, Unmehopa UA, Berland C, Dólleman S, Hardonk M, Cruciani-Guglielmacci C, Faust RP, Wenning R, Maya-Monteiro CM, Kalsbeek A, Aponte Y, Luquet S, Serlie MJM, la Fleur SE. Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents. Metabolism 2023, 155696. PMID: 37804881, DOI: 10.1016/j.metabol.2023.155696.Peer-Reviewed Original ResearchGenetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review.
van der Meer R, Mohamed SA, Monpellier VM, Liem RSL, Hazebroek EJ, Franks PW, Frayling TM, Janssen IMC, Serlie MJ. Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review. Obes Rev 2023 PMID: 37632325, DOI: 10.1111/obr.13626.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsBariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production.
Yildirim V, Ter Horst KW, Gilijamse PW, van Harskamp D, Schierbeek H, Jansen H, Schimmel AW, Nieuwdorp M, Groen AK, Serlie MJ, van Riel NA, Dallinga-Thie GM. Bariatric surgery improves postprandial VLDL kinetics and restores insulin mediated regulation of hepatic VLDL production. JCI Insight 2023 PMID: 37432744, DOI: 10.1172/jci.insight.166905.Peer-Reviewed Original ResearchBrain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study
van Galen K, Schrantee A, ter Horst K, la Fleur S, Booij J, Constable R, Schwartz G, DiLeone R, Serlie M. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nature Metabolism 2023, 5: 1059-1072. PMID: 37308722, DOI: 10.1038/s42255-023-00816-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDiet-induced weight lossCerebral neuronal activityStriatal dopamine releaseWeight lossCrossover studyDopamine releaseNeuronal activityIntragastric glucoseNeuronal responsesSuccessful weight lossHealthy body weightSignificant weight lossBrain responsesPathological feeding behaviorsWeight regainHunger scoresLipid infusionLean participantsCaloric intakePlasma hormonesObesityBody weightInfusionNutrient signalsHigh rateRandomized clinical trial: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition.
Gompelman M, Wezendonk GTJ, Wouters Y, Beurskens-Meijerink J, Fragkos KC, Rahman FZ, Coolen JPM, van Weerdenburg IJM, Wertheim HFL, Kievit W, Akkermans RP, Serlie MJ, Bleeker-Rovers CP, Wanten GJA. Randomized clinical trial: Long-term Staphylococcus aureus decolonization in patients on home parenteral nutrition. Clin Nutr 2023, 42: 706-716. PMID: 36965196, DOI: 10.1016/j.clnu.2023.03.010.Peer-Reviewed Original Research
News
News
- March 03, 2025
The Role of Diet in Managing Obesity
- November 27, 2024Source: Medscape
Eating More Red Meat Could Increase Type 2 Diabetes Risk
- April 16, 2024
New Professors in the Department of Internal Medicine
- March 20, 2024
How the Standard American Diet Affects Your Brain
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Yale School of Medicine
300 Cedar Street
New Haven, CT 06519
United States
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