Manraj Singh Sra, MBBS
he/him/his
Hospital ResidentCards
About
Research
Publications
2026
Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis
Chetlapalli K, Ito S, Ng D, Sra M, Wang D, Krumholz H, Krishnamurti L, Pandya A, Goshua G. Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis. Blood 2026 PMID: 42227898, DOI: 10.1182/blood.2025032290.Peer-Reviewed Original ResearchStandard-of-careAllo-HSCTGene therapyAllogeneic stem cell transplantationEra of gene therapyCost-effectiveness analysisStem cell transplantationPainful vaso-occlusive crisesIncremental cost-effectiveness ratioVaso-occlusive crisisCost-effectiveness ratioSickle cell diseaseHaploidentical transplantationCell transplantationBlood transfusionChronic anemiaProspective studyCost-effectiveness thresholdTreatment optionsPain managementDisease ameliorationPrimary outcomeSecondary outcomesCell diseaseBlood disordersAssociation of longitudinal changes in nutritional status with survival outcomes in childhood cancer
Sra M, Ganguly S, Sasi A, Bansal A, Verma V, Sharma S, Kumari M, Pushpam D, Batra A, Agarwala S, Bakhshi S. Association of longitudinal changes in nutritional status with survival outcomes in childhood cancer. Clinical Nutrition 2026, 63: 106704. PMID: 42296830, DOI: 10.1016/j.clnu.2026.106704.Peer-Reviewed Original ResearchEvent-free survivalInferior event-free survivalOverall survivalChildhood cancerAssociated with inferior event-free survivalMid-upper arm circumference z scoreAssociated with inferior overall survivalSerial measurementsWeight lossMid-upper arm circumferenceMultivariate Cox regression modelInferior overall survivalAbstractText Label="Background &Diagnosis of malignancyTreatment of childhood cancerCohort of patientsMiddle-income countriesAssociated with complicationsAssociation of longitudinal changesFollow-up visitLongitudinal changesProspective cohort studyMeasurements of weightTertiary care hospitalCox regression modelsMonoclonal gammopathy of clinical significance: a multisystem review
Sra M, Rajkumar S, Kumar S. Monoclonal gammopathy of clinical significance: a multisystem review. Blood Cancer Journal 2026 PMID: 42215470, DOI: 10.1038/s41408-026-01528-5.Peer-Reviewed Original ResearchMonoclonal gammopathy of clinical significanceMonoclonal gammopathyMonoclonal proteinClinical manifestationsClonal plasma cell proliferative disorderPlasma cell proliferative disorderProgression of monoclonal gammopathyCell proliferative disorderMultiple organ systemsProtein-producing clonesSchnitzler syndromePOEMS syndromeOcular diseasesClinical featuresMonoclonal immunoglobulinClinical significanceMultisystem disorderTreatment strategiesProliferative disordersClinical trialsDisease progressionDisease entityTEMPI syndromeObservational studyDiagnostic approachCost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds
Wang D, Sra M, Ng D, Tadepalli A, Rinaldi K, Ito S, Cuker A, Goshua G. Cost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds. Blood Advances 2026 PMID: 42206692, DOI: 10.1182/bloodadvances.2026020143.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioCost-effectiveness analysisIron deficiencyPregnant womenRegular screeningDevelopmental deficitsCost-effectiveness ratioMaternal iron deficiencyThird-trimester screeningWorld Health OrganizationIron deficiency screeningTrimester of pregnancyClinical status quoID screeningPoor birth outcomesFerritin rangeMaternal morbidityTrimester screeningThird trimesterBirth outcomesDeficiency screeningProportion of mothersNo screeningInfusion timePregnant individualsCost-effectiveness of frontline eltrombopag with immunosuppressive therapy for severe aplastic anemia
Ito S, Potnis K, Ng D, Patel K, Sra M, Shallis R, Podoltsev N, Kewan T, Stempel J, Mendez L, Huntington S, Stahl M, Zeidan A, Bewersdorf J, Goshua G. Cost-effectiveness of frontline eltrombopag with immunosuppressive therapy for severe aplastic anemia. Blood Red Cells & Iron 2026, 2: 100076. PMID: 42077391, PMCID: PMC13134686, DOI: 10.1016/j.brci.2026.100076.Peer-Reviewed Original ResearchThis study investigates how trainee-led teams developed updated consensus guidelines for managing peritoneal surface malignancies, demonstrating effective collaboration models for complex medical evidence synthesis.Intravenous Fosaprepitant Versus Oral Aprepitant for Children Receiving Highly Emetogenic Chemotherapy: An Investigator‐Initiated Randomized, Open‐Label, Non‐Inferiority Trial
Rasheed A, Ganguly S, Singh M, Kumar S, Batra A, Pushpam D, Vishnubhatla S, Pillai A, Joison A, Sharma S, Bakhshi S. Intravenous Fosaprepitant Versus Oral Aprepitant for Children Receiving Highly Emetogenic Chemotherapy: An Investigator‐Initiated Randomized, Open‐Label, Non‐Inferiority Trial. Pediatric Blood & Cancer 2026, 73: e70171. PMID: 41823195, DOI: 10.1002/1545-5017.70171.Peer-Reviewed Original ResearchConceptsAprepitant groupCR rateSeverity of nauseaNon-inferiorityNon-inferiority trialAcute phaseComplete responseOpen-labelEmetogenic chemotherapyHighly emetogenic chemotherapyIntention-to-treat analysisRate of vomitingOverall phaseAdverse effectsNon-inferiority marginFosaprepitant groupOral aprepitantIntravenous doseInvestigator-initiatedPrimary outcomeAprepitantChildren Aged 5Secondary outcomesFosaprepitantVomitingGlobal, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023
Collaborators G, Bhangdia K, May M, Kocarnik J, Pritchett N, Crist A, Penberthy L, Acheson A, Deitesfeld L, Bhoomadevi A, Aalruz H, Ababneh H, Abaraogu U, Abbas N, ElHafeez S, Abdel-Hameed R, Abdel-Rahman W, Abdelwahab S, Abdi S, Abdollahi A, Abdoun M, Abdulah D, Abdullah, Abdullahi A, Abdul-Rahman T, Abdykerimova K, Abebe M, Abedi A, Abedini M, Abegaz K, Abie A, Abie D, Abiodun O, Aboagye R, Abolhassani H, Abonie U, Abrar M, Abu Z, Abu Farha R, Abuadas F, Abubakar A, Abubakar B, Abu-Gharbieh E, Abukhadijah H, Abusalah M, Abushanab D, Acharya S, Acuna J, Adams L, Addo I, Adebiyi B, Adedia D, Adedokun K, Adegoke N, Adekanmbi V, Adekola S, Adesina M, Adewuyi H, Adeyeoluwa T, Adiga U, Adnan M, Adnani Q, Adzigbli L, Afolabi A, Afzal M, Agide F, Sobrinho C, Agyemang-Duah W, Ahinkorah B, Ahlstrom A, Ahmad A, Ahmad D, Ahmad K, Ahmad M, Ahmadi A, Ahmadi M, Ahmed A, Ahmed A, Ahmed A, Ahmed G, Ahmed H, Ahmed F, Ahmed M, Ahmed M, Ahmed M, Ahmed N, Ahmed S, Ajala D, Ajami M, Akhigbe R, Akhtar M, Al Awaidy S, Al Hamad H, Al Hasan S, Al Qadire M, Al Thaher Y, Al Zoubi M, Alam R, Alamrew A, Albano D, Albashtawy M, Al-Daken L, Aldossary M, Aleidi S, Alemayehu B, Alemnew F, Alfalki A, Algammal A, Alhalaiqa F, Al-Hanawi M, Ali I, Ali M, Ali M, Ali R, Ali S, Alif M, Alimohammadi M, Rokny H, Alipour M, Al-Jabi S, Aljasir M, Al-Jumaily A, Aljunid S, Alkhatib A, Alnaeem M, Alniss H, Alomari M, AlQudah M, Alqudah M, Al-Qudimat A, Alseragi W, Alshaeri H, Alshahrani N, Alshetaiwi H, Altaany Z, Altwalbeh D, Alvis-Guzman N, Al-Worafi Y, Aly H, Alyahya M, Alzoubi K, Al-Zubairi A, Amin T, Amindarolzarbi A, Aminu N, Amobonye A, Amu H, Amzat J, Ancuceanu R, Anderlini D, Anil A, Ansariniya H, Antwi M, Anuoluwa I, Anvari S, Anwar S, Anwer R, Arabi H, Arabloo J, Arafat M, Aravkin A, Areda D, Arjmand G, Arooj M, Arul S, Arumuganainar D, Aryntayeva N, Asemu M, Asghari-Jafarabadi M, Ashebr H, Ashraf S, Ashraf T, Ashrafi M, Aslam M, Assariparambil A, Assembekov B, Atsbaha A, Atta J, Aurangzeb K, Awad M, Awan S, Ayyoubzadeh S, Azad A, Azadnajafabad S, Azadnia A, Azami H, Azarboo A, Aziz M, Aziz N, Sheeba B, Badar M, Badiye A, Bagheri N, Bahurupi Y, Baig A, Bains L, Bakhshali M, Balcha W, Banach M, Barati S, Bardhan M, Barqawi H, Abu Bashar, Bastan M, Batra K, Bauckneht M, Beeraka N, Behnam B, Behzadi P, Belay A, Belayneh A, Belayneh M, Bilgin G, Bell A, Bendardaf R, Tune S, Berhie A, Berihun A, Beyene F, Bhadoria A, Bhardwaj P, Bhardwaj P, Bhatnagar A, Bhattacharjee S, Bhattarai A, Bhatti G, Bhatti J, Bhuyan S, Biswas B, Biswas M, Bizuneh A, Bj⊘rge T, Bolourinejad P, Bosoka S, Carvajal A, Bouaoud S, Boukhiam M, Braithwaite D, Brenner H, Busch F, Bustanji Y, Cao S, Carreras G, Carvalho F, Castañeda-Orjuela C, Cattafesta M, Cegolon L, Cembranel F, Cerrai S, Shivamadhu M, Chakraborty C, Chakraborty S, Chandika R, Chang J, Chattu V, Chaudhary A, Chaudhuri S, Chemeda G, Chen H, Chen H, Chen X, Cho W, Chowdhury J, Chu D, Chukwu C, Chukwu I, Chung S, Cioffi I, Collado-Mateo D, Columbus A, Conde J, Cosma C, Costa V, Cramb S, Cruz-Martins N, da Silva A, Dadras O, Dagnew G, Dai X, Dandona L, Dandona R, Dardas L, Dee E, Dehesh P, Denova-Gutiérrez E, Dervišević M, Desale A, Desta A, Devanbu V, Devegowda D, Dewan S, Dhital S, Dhungel B, Di Pumpo M, Diaz D, Didehvar K, Phuong T, Dohare S, Dokova K, Dondi F, Dorostkar F, dos Santos W, Doshi O, Dowou R, Du J, Duraisamy S, Dutta S, Dutta S, Eftekharimehrabad A, Eghbali F, Eikemo T, Ekholuenetale M, Ekundayo T, Desouky E, Omri A, Sayed I, Zaki M, Eladl M, Elbarazi I, El-Deyarbi M, Elemam N, Elhadi M, Elhadi Y, Elmorsi R, Elmoselhi A, Eltahawy A, Emagneneh T, Eshetie S, Eskandarieh S, Ezenwankwo E, Fabbro E, Fadavian H, Fagbamigbe A, Fahim A, Faiz R, Fakhradiyev I, Falzone L, Farahmand M, Faraji S, Faramarzpour M, Fareed M, Farhana A, Farhana Z, Faris M, Farooq S, Fatima Z, Feizkhah A, Fekadu G, Ferrari A, Ferreira N, Fischer F, Fisher J, Flor L, Florin B, Forray A, Rodrigues C, Fukumoto T, Gaal P, Gadanya M, Gadeka D, Gajdács M, Gallus S, Gao D, Garlasco J, Gashaw A, Gautam R, Gebregergis M, Gebremeskel T, Gelaw B, Matin A, Gerema U, Getahun G, Ghadirian F, Ghaffari K, Ghamkhar A, Ghasemi M, Assl S, Ghashghaee A, Ghassemi F, Ghazy R, Gholami E, Ghotbi E, Ghuge A, Giannakis K, Gilani S, Girombelli A, Gohari K, Golchin A, Golechha M, Golmohammadi M, Gorini G, Goyal S, Grum T, Guan S, Gubari M, Guha A, Gunawardane D, Guo Z, Guo Z, Gupta B, Gupta V, Hadi N, Haghmorad D, Haj-Mirzaian A, Halder P, Hamad I, Hamadeh R, Hamdy N, Hanif A, Hanson V, Haq M, Haque A, Haque A, Haro J, Harsini S, Has E, Hasaballah A, Hasan I, Hasan K, Hashempur M, Hassan T, Hay S, Heidari G, Heidari M, Heli H, Herteliu C, Marambage K, Hewage S, Heydari M, Holla R, Hoseinzadeh M, Hossain A, Hossain J, Hossain S, Hossain M, Hsairi M, Huang J, Huang Y, Huda M, Husain W, Hushmandi K, Hussain J, Hussain S, Hussein D, Hussein M, Hwang B, Ibitoye O, Ibitoye S, Ibrahim R, Ibrayeva A, Iftikhar P, Ikiroma A, Ilesanmi O, Ilic I, Ilic M, Ilyas M, Ionescu A, Ionescu R, Irham L, Isa M, Islam R, Islam S, Islami F, Ismail F, Jacob L, Jacobsen K, Jadidi-Niaragh F, Jaganathan V, Jahanshahi F, Jahrami H, Jairoun A, Jaiswal A, Jakovljevic M, Jalal S, Jalali P, Jalloh M, Jamal A, Jamal Q, Jamali N, James J, Jamil H, Janardhanan R, Jawaid T, Abed Q, Jayaram S, Jayasinghe Y, de Dieu H, Jee S, Jema A, Jeong S, Jiang F, Jiang M, Jin W, Jokar M, Jonas J, Joo T, Jose J, Joseph A, Joseph N, Joshi K, Joshua C, Jozwiak J, Kaambwa B, Kabir A, Kalankesh L, Kalavani K, Kamal M, Kankam S, Kanmodi K, S S, Kantar R, Kapoor N, Kar D, Kar S, Karajizadeh M, Karasneh R, Karimi M, Behnagh A, Kashoo F, Kashyap M, Kassaw N, Kausar M, Khader Y, Khalili P, Khalilian A, Khalili-Tanha G, Khalis M, Khamesipour F, Khan A, Khan G, Khan I, Khan A, Khan M, Khan M, Khan M, Khan S, Khan S, Khan S, Khan Y, Khasbage S, Khatab K, Khatatbeh M, Zarandi P, Khidri F, Khoshvaght P, Khubchandani J, Kibru E, Kimokoti R, Kinfu Y, Kisa A, Kobyliak N, Kocsis T, Kompani F, Koomson-Yalley E, Kostev K, Koul A, Kretchy I, Kuanar A, Kuchay R, Kuddus M, Kulimbet M, Kumar G, Kumar N, Kumar R, Kumar V, Kusuma A, Kusuma D, Kuttybayev A, Kyei G, La Vecchia C, Lahariya C, Lai D, Lai J, Lakanova B, Lám J, Lan T, Landires I, Lanfranchi F, Lantos T, Latif M, Ledda C, Lee I, Lee S, Lee W, Lema G, Leong E, Leshargie C, Li J, Li M, Lian Y, Liu R, Liu X, Liu X, Liu X, Liyeh T, Lodhi M, Lopukhov P, Lugo A, Luo P, Lutambi A, Lytras M, Amin H, Sheng-Kai K, Feei Z, Maalman R, Magwe E, Mahmood N, Mahmoud M, Mahumud R, Malik A, Malik T, Malta D, Mamand D, Mansoor F, Mansourian M, Mansournia M, Mantovani L, Manzoor S, Maqsood K, Marateb H, Martini S, Martorell M, Marzo R, Marzouk S, Mathur M, Mathur N, Matozinhos F, McPhail S, Meena J, Mehrotra R, Mehto S, Meles H, Melwani S, Menezes G, Mengistie E, Meo A, Meretoja T, Mesfin R, Mestrovic T, Metwally M, Mini M, Mirghafourvand M, Mirshahvalad S, Mishra A, Misra S, Mithra P, Mohamed J, Mohamed M, Mohamed N, Mohammad T, Mohammadi M, Mohammadian-Hafshejani A, Mohammed A, Mohammed A, Mohammed S, Mohan S, Mohseni P, Moka N, Mokdad A, Momani S, Moradi M, Moradi Y, Moraga P, Morrison S, Motaharinezhad F, Motappa R, Kiasary S, Mousnad M, Mubarak R, Mubarik S, Muhammad J, Mukherjee S, Mulita F, Mulugeta C, Mumtaz S, Munshi A, Murillo-Zamora E, Murray C, Muse A, Mushtaq A, Mushtaq S, Musina A, Mustapha M, Muthupandian S, Myung W, Nagarajan A, Naghavi M, Naghavi P, Nair T, Najmuldeen H, Nartey Y, Nashwan A, Nasiri H, Natto Z, Nauman J, Naveed M, Nawsherwan, Nayak S, Nayon F, Nazri-Panjaki A, Nega A, Negru A, Nematollahi M, Niazi R, Nieddu L, Nikolouzakis T, Nikpoor A, Niranjan V, Nisro A, Nnyanzi L, Nomura S, Noreen M, Noreen S, Nugen F, Nyande F, Nzoputam C, Nzoputam O, Oancea B, Obakachi V, Oghenetega O, Oh I, Okati-Aliabad H, Okeke S, Okekunle A, Okonji O, Olagunju A, Olawuyi A, Omage F, Omonisi A, Ong A, Onwujekwe O, Ordak M, Orru H, Ortega-Altamirano D, Ortiz-Prado E, Osborne A, Osei E, Othman E, Owusu I, Oyeyemi I, Ozsahin I, Mahesh P, Padron-Monedero A, Padubidri J, Paija D, Palena G, Paluvai T, Pana A, Panaite D, Panda S, Panda-Jonas S, Katare D, Pandi-Perumal S, Panigrahi S, Paranjkhoo P, Parikh R, Park C, Park S, Park T, Parvar S, Pasovic M, Passera R, Patel H, Patel J, Patel M, Patel N, Patel R, Patel S, Toroudi H, Pekarcikova J, Pestell R, Peter O, Pham T, Pierannunzio D, Piracha Z, Pirouzpanah S, Plotnikov E, Porntaveetus T, Pourasghary S, Pourghazi F, Pourtaheri N, Pradhan J, Prakasham T, Prasad C, Prashant A, Prates E, Priya H, Puthussery S, Qanash H, Qasim N, Qazi A, Qi Z, Qurashi S, Deepthi R, Radhakrishnan V, Shahraki H, Raghav Y, Raghuveer P, Rahim H, Rahimi S, Rahman F, Rahman M, Rahman M, Rahman M, Rahman M, Rahmani A, Rahmati M, Raj J, Rajaa S, Rajendran J, Rajizadeh M, Rakhimov K, Ramadan M, Ramasamy C, Ramasamy S, Farani M, Ramírez-Vélez R, Ramzan M, Rancic N, Rathish D, Rauniyar S, Rawaf S, Ray A, Rayati M, Rehman A, Rehman N, Reis-Mendes A, Rezaei M, Rezaei N, Rezaei N, Rocha H, da Silva T, Rojas-Rueda D, Roshandel G, Roshanshad A, Rouzbahani H, Rouzbahani R, Rouzbahani S, Roy S, Saber-Ayad M, Sadarangani K, Saddik B, Sadegh T, Sadeghi E, Sadeghi-Ghyassi F, Saeed M, Saeed U, Saeedi M, Sah A, Rafsanjani A, Sharif-Askari F, Sharif-Askari N, Sahebkar A, Sahoo U, Sahoo P, Saif Z, Saki M, Salabat D, Salami A, Salaroli L, Saleem R, Saleh M, Salehi, Samargandy S, Samodra Y, Samy A, Sangle S, Sanjari E, Santric-Milicevic M, Saravanan A, Sargazi S, Sarmadi M, Sarode S, Sathian B, Satija A, Sattarahmady N, Far M, Sawhney M, Schinckus C, Sedigh A, Seifmanesh H, Šekerija M, Selvaraj S, Selvaraj V, Semreen M, Sengupta P, Senthilkumaran S, Serban D, Sethi Y, Alshohadaei S, Seylani A, Shahab M, Shahbaz M, Shahid S, Shahid S, Shahid W, Shahrahmani F, Shahsavari H, Shaikh M, Sham S, Shamim M, Shams F, Shamsi A, Shamsutdinova A, Shanawaz M, Shankar A, Sharif M, Sharifan A, Sharma B, Sharma M, Sharma R, Sharma U, Sharma V, Shawahna R, Shayan M, Sheida F, Sheidaei A, Shenoy R, Shetty M, Shetty S, Shiferaw D, Shimels T, Shittu A, Shivamallu C, Shivarov V, Shoaib A, Eshkiki Z, Shorofi S, Shrestha A, Shrestha G, Shrestha S, Shuval K, Si Y, Siavashpour Z, Sibuyi N, Siddig E, Sikdar M, Singh B, Singh H, Singh J, Singh K, Singh L, Singh P, Singh P, Singh P, Singh R, Singh R, Singh S, Singh S, Singh S, Sinha M, SobhZahedi M, Sobia F, Solbana L, Soleimani A, Solikhah S, Soliman S, Song W, Sood A, Sood P, Singh M, Sree L, Subramaniyan V, Sulaieva O, Odidi M, Suleman M, Meo A, Sun Z, Sundaram S, Sundaram T, Suresh V, Swain C, Szarpak L, Y S, Tabarés-Seisdedos R, Tabatabaei S, Tabatabaeizadeh S, Taghizadeh-Hesary F, Taha S, Taiba J, Talaat I, Tan K, Tanabayeva S, Tanveer M, Tariq S, Tavangar S, Tbakhi A, Tefera F, Tekola A, Temsah M, Tesfay F, Tesfu A, Thapar R, Theyra-Enias H, Thiruvengadam M, Thiruvengadam R, Ticoalu J, Tiwari K, Topor-Madry R, Toriola A, Touvier M, Tran T, Tran T, Udoakang A, Ullah A, Ullah S, Umakanthan S, Umar S, Unim B, Unnikrishnan B, Urmey J, Vaithinathan A, Varasteh J, Varma P, Vasishta S, Venkidasamy B, Verma P, Violante F, Vladimirov S, Vlassov V, Volovat S, Waheed Y, Wahidin M, Wang X, Wang Y, Westerman R, Wibowo Y, Wickramasinghe D, Wickramasinghe N, Wireko A, Woldehana N, Wolf A, Wongnaah F, Worku M, Wu J, Wu P, Wu S, Wulandari R, Xiao G, Xie W, Xu W, Xu Y, Yahoo S, Yahya G, Yano Y, Yao L, Yarahmadi A, Yaya S, Yeganeh M, YektaKooshali M, Yezli S, Yismaw Y, Yon D, Yonemoto N, Yu C, Yuan C, Yuan Q, Yuvali M, Zadnik V, Zafar M, Zaghampour M, Zairov D, Zaki N, Zamagni G, Zare I, Sakhvidi M, Zawiah M, Zeariya M, Zeng Q, Zhang D, Zhang L, Zhang X, Zhao H, Zhao Z, Zhong C, Zhu B, Zhu S, Zhu Z, Zhumagaliuly A, Zia H, Zielińska M, Zoromba M, Zyoud S, Vollset S, Vos T, Force L, Ng M. Global, regional, and national burden of breast cancer among females, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet Oncology 2026, 27: 302-326. PMID: 41785894, DOI: 10.1016/s1470-2045(25)00730-2.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-standardised incidence ratesDisability-adjusted life yearsBreast cancer incidenceBreast cancer burdenGlobal incident casesHigh-income groupsLow-income groupsGlobal burdenGBD causeCancer incidenceCancer burdenMortality rates of female breast cancerLowest age-standardised incidence ratesIncident cases of breast cancerNational burdenCancer disability-adjusted life yearsRisk factors associated with breast cancerHighest age-standardised incidence rateBurden of breast cancerCause of death ensemble modellingFactors associated with breast cancerBreast cancerMortality-to-incidence ratioRisk factorsCost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding
Wang D, Sra M, Ito S, Ng D, Glaeser-Khan S, Wang D, Hirniak S, Lee A, Cuker A, Goshua G. Cost-effectiveness of first-line IV vs oral iron for iron-deficiency anemia in women with heavy menstrual bleeding. Blood Advances 2026, 10: 1508-1517. PMID: 41504430, PMCID: PMC12952766, DOI: 10.1182/bloodadvances.2025018315.Peer-Reviewed Original ResearchConceptsHeavy menstrual bleedingIV iron dextranIron deficiency anemiaQuality-adjusted life yearsOral ferrous sulfateFirst-line treatmentIron dextranOral ironMenstrual bleedingCost-effective treatmentIron deficiencyFrequent gastrointestinal side effectsIV iron sucroseOral iron therapyFirst-line therapyQuality-adjusted life-year benefitsFirst-line optionIncremental cost-effectiveness ratioGastrointestinal side effectsCohort of womenCost-effectiveness ratioIron therapyIron sucroseIV ironTreatment delay
2025
Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis
Glaeser-Khan S, Ito S, Sra M, Richmond R, Bona R, Krumholz H, Croteau S, Cuker A, Goshua G. Emicizumab for preventing intracranial hemorrhage in infants with severe hemophilia A: a cost-effectiveness analysis. Blood Advances 2025, 9: 6237-6245. PMID: 40795232, PMCID: PMC12744270, DOI: 10.1182/bloodadvances.2025016822.Peer-Reviewed Original ResearchIncremental cost-effectiveness ratioSevere hemophilia AIntracranial hemorrhageEmicizumab prophylaxisHemophilia ASevere HAWTP thresholdStandard careProphylactic factor replacementUS societal perspectiveInfants Aged 0Markov cohort modelLifetime time horizonCost-effectiveness ratioProbabilistic sensitivity analysesFVIII inhibitorsBleeding riskFactor replacementSevere complicationsEmicizumabAccess placementCentral venous access placementPrimary outcomeProphylaxisNeurological disabilityEarly stoppage of empirical antibiotic therapy in paediatric acute leukaemia with high-risk febrile neutropenia: a randomized, open-label, phase 3, non-inferiority trial
Chellapuram S, Kn S, Singh M, Giri R, Pushpam D, Batra A, Vishnubhatla S, Ganguly S, Bakhshi S. Early stoppage of empirical antibiotic therapy in paediatric acute leukaemia with high-risk febrile neutropenia: a randomized, open-label, phase 3, non-inferiority trial. EClinicalMedicine 2025, 90: 103610. PMID: 41245542, PMCID: PMC12612994, DOI: 10.1016/j.eclinm.2025.103610.Peer-Reviewed Original ResearchHigh-risk febrile neutropeniaEmpirical antibiotic therapyAbsolute neutrophil countPaediatric acute leukaemiaDiscontinuation of empirical antibiotic therapyFebrile neutropeniaEarly discontinuationAcute leukemiaFever recurrenceClinical Trials RegistryNon-inferiorityOpen-labelAntibiotic therapyNeutrophil countDays of empiric antibiotic therapyRecovery of absolute neutrophil countNon-inferior to continuationRecovery of neutrophil countsStop armEarly stoppageClinical Trial Registry of IndiaThird-line antibioticsHospital readmissionNon-inferiority marginChildren Aged 2
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