Farida Ahangari, MD
Assistant Professor of Medicine (Pulmonary)Cards
About
Research
Publications
2026
B77-08 Modified RNA Extraction Method to Eliminate Agarose Carryover Interferences in Precision Cut Lung Slices
Marti Munoz J, Rangel R, Anderson S, Deiuliis G, Manning E, Ahangari F, Pandit A, Kaminski N. B77-08 Modified RNA Extraction Method to Eliminate Agarose Carryover Interferences in Precision Cut Lung Slices. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.5390. DOI: 10.1093/ajrccm/aamag162.5390.Peer-Reviewed Original ResearchPlant KitRNA extraction methodsIntact rRNARNA extractionRNA quantityPrecision cut lung slicesExtraction methodYield of RNATranscriptional integrityPlantsYieldGene expressionRNA yieldRNA integrityRNARRNALung slicesAgaroseCulture conditionsExtractionStudy biologyEthidium homodimer-1Human lungRNA quantificationInstitutional review boardC71-21 Emerging Biomarkers in Interstitial Lung Disease and Their Role in Identifying Progressive Phenotypes
Carducci C, Abu Hussein N, Velasco Alzate K, Azim A, Ahangari F, Kaminski N. C71-21 Emerging Biomarkers in Interstitial Lung Disease and Their Role in Identifying Progressive Phenotypes. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2787. DOI: 10.1093/ajrccm/aamag162.2787.Peer-Reviewed Original ResearchInterstitial lung diseaseIdiopathic pulmonary fibrosisGender-Age-PhysiologyMatrix metalloproteinase-7Gender-age-physiology indexProgressive pulmonary fibrosisSerum concentrationsDisease progressionPulmonary fibrosisPrognostic performanceLung diseaseFibrosing ILDsBiomarkers of disease activitySerum matrix metalloproteinase-7C-C motif chemokine ligand 18Associated with disease progressionBiomarker-driven strategiesHigher serum levelsMatrix metalloproteinase-7 concentrationsResults No significant differencesPulmonary function impairmentRisk of deathLung function declineCCL18 concentrationsCCL18 levelsD29-18 Targeting Mir-33 Ameliorates Pulmonary Fibrosis Through Metabolic Reprogramming of Macrophages and Improves Lung Function Beyond Nintedanib
Salimi M, Lin L, Johad K, Velasco Alzate K, Anderson S, Rangel R, Deiuliis G, Kaminski N, Ahangari F. D29-18 Targeting Mir-33 Ameliorates Pulmonary Fibrosis Through Metabolic Reprogramming of Macrophages and Improves Lung Function Beyond Nintedanib. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2878. DOI: 10.1093/ajrccm/aamag162.2878.Peer-Reviewed Original ResearchHuman precision-cut lung slicesPulmonary fibrosisPulmonary function testsIn situ hybridizationIPF patientsHealthy controlsMetabolic reprogrammingFunction testsLung functionLung tissueMacrophage metabolismHistological analysisAmeliorated pulmonary fibrosisInstillation of bleomycinBleomycin-induced PF modelPrecision-cut lung slicesVehicle-treated groupMetabolic reprogramming of macrophagesImprove lung functionProgression of fibrosisTotal respiratory complianceFatal lung diseaseReprogramming of macrophagesAntifibrotic genesMacrophage signatureA74-12 An Ex Vivo Model of Induced Lung Aging Reveals Age-dependent Predisposition to Oxidative Stress and Cellular Senescence
De Man R, Rangel R, Marti Munoz J, Khoury J, Anderson S, Lin L, Adams T, Ahangari F, Manning E, Kaminski N. A74-12 An Ex Vivo Model of Induced Lung Aging Reveals Age-dependent Predisposition to Oxidative Stress and Cellular Senescence. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.5347. DOI: 10.1093/ajrccm/aamag162.5347.Peer-Reviewed Original ResearchPrecision-cut lung slicesProportion of Ki67-positive cellsEx vivo modelKi67-positive cellsAging LungLung diseasePositive cellsCellular senescenceLung slicesAge-related lung diseasePredisposition to oxidative stressProportion of positive cellsSenescence inductionHydrogen peroxide treatmentSenescence marker p21P21-positive cellsCdkn1a (p21Differential gene expressionDose-dependent effectDose-dependent mannerOxidative stress-induced cellular senescenceFetal bovine serumAlveolar simplificationStress-induced cellular senescenceProliferation markersA109-23 The Profibrotic Effect of Mechanical Force on Airway Basal Cells in Pulmonary Fibrosis
Lin L, Salimi M, Du H, Khoury J, Giuseppe D, Alzate K, Szafron J, Manning E, Kaminski N, Ahangari F. A109-23 The Profibrotic Effect of Mechanical Force on Airway Basal Cells in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2423. DOI: 10.1093/ajrccm/aamag162.2423.Peer-Reviewed Original ResearchAirway basal cellsIdiopathic pulmonary fibrosisPulmonary fibrosisProfibrotic effectsBasal cellsBleomycin-treated miceTGF-b1 expressionIdiopathic pulmonary fibrosis progressionAirway epithelial cellsScarring lung diseaseAir-liquid interfaceDifferentiation stateAnnexin V-FITC/PI stainingGene expressionFibrotic remodelingFibrosis progressionNo significant changesHealthy miceAbnormal responseLung diseaseVentilated lungFibrotic genesAlveolar destructionElevated mechanical stressEpithelial cellsThe Interplay of Airway Epithelium and Biomechanical Stress in Pulmonary Fibrosis
Lin L, Khoury J, Zhang G, Szafron J, Manning E, Ahangari F. The Interplay of Airway Epithelium and Biomechanical Stress in Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2026, aanag066. PMID: 42089315, DOI: 10.1093/ajrcmb/aanag066.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisAirway epitheliumPulmonary fibrosisEpithelial responsesEpithelial cellsResponse of airway epithelial cellsPathogenesis of idiopathic pulmonary fibrosisRegulation of lung functionProgression of idiopathic pulmonary fibrosisAirway epithelial cellsProgression of fibrosisAirway epithelial responsesPro-fibrotic responseIndicators of disease onsetFatal lung diseaseEarly indicatorLung fibrosisAbnormal responseLung diseaseDisease onsetLung functionLung tissueFibrosisAirwayTherapeutic interventionsVascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury
Yoon Y, Sharma L, Tang W, Kirk S, Raredon M, Ahangari F, Khoury J, Qian H, Ke Y, Tulapurkar M, Liu R, Luan Y, Yuan Q, Chen L, Birukov K, Simons M, Wu D, Niklason L, Kaminski N, Yuan Y. Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury. Circulation Research 2026, 138: e326094. PMID: 41822962, PMCID: PMC13007730, DOI: 10.1161/circresaha.124.326094.Peer-Reviewed Original ResearchVEGF-DAcute lung injuryBarrier-protective effectsVascular integrityLung injuryLipopolysaccharide-induced acute lung injury modelIntravenous administrationTNF-aParacrine signalingModel of acute lung injuryPulmonary vascular integrityLigand-receptor interactionsImmune cell infiltrationAcute lung injury modelLung vascular integrityVEGFR2-dependent signalingLung injury modelEndothelial barrier integrityEndothelial barrier functionRNA sequencing dataMicrovascular endothelial cellsInhibition of VEGFR2Microvascular nichePharmacological blockadeAssociated with pathways
2025
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.Peer-Reviewed Original ResearchComplex cellular dynamicsCellular dynamicsSingle-cell transcriptomic dataIn silico drug discoverySingle-cell transcriptomicsTranscriptome dataPotential therapeutic drug candidateComplex diseasesHuman diseasesIdiopathic pulmonary fibrosisTherapeutic drug candidateCell embeddingDrug discoveryPulmonary fibrosisDrug candidatesDisease progressionHuman tissuesHuman precision-cut lung slicesDynamic analysisPrecision-cut lung slicesPathological landscapeComputational toolsAnti-fibrotic effectsUnagiTranscriptomeSeparation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1
Smoom R, May C, Lichtental D, Bar-Ness K, Rangel R, Khoury J, Nachmani D, Avrahami D, Ahangari F, Skordalakes E, Kaminski N, Kaestner K, Tzfati Y. Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1. Nucleic Acids Research 2025, 53: gkaf507. PMID: 40530700, PMCID: PMC12203905, DOI: 10.1093/nar/gkaf507.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsDisease Models, AnimalDNA DamageDNA HelicasesDyskeratosis CongenitaFetal Growth RetardationGrowth DisordersHematopoiesisHumansIntellectual DisabilityLimb Deformities, CongenitalLungMiceMicrocephalyPoint MutationTelomereTelomere HomeostasisX-Linked Intellectual DisabilityConceptsHoyeraal-Hreidarsson syndromeTelomere protectionLength regulationTelomere length regulationTelomere-related diseasesTelomere biology disordersDNA helicaseMouse genomeGenome stabilityMouse modelMouse telomeresAberrant hematopoiesisGenomic instabilityPoint mutationsHouse miceTelomeric DNA damageAnaphase bridgesRTEL1Amino acidsTelomereMechanistic rolesDNA damageMutationsIsoleucine mutationGenomeEpigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks
Kurbanov D, Ahangari F, Adams T, De Man R, Tang J, Carlon M, Abu Hussein N, Cortesi E, Zapata M, De Sadelaar L, Wuyts W, Vanaudenaerde B, Kaminski N, McDonough J. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 328: l456-l462. PMID: 39970931, PMCID: PMC12169420, DOI: 10.1152/ajplung.00171.2024.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis tissuePulmonary fibrosisLung tissueEpigenetic clocksPotential of DNA methylationDNA methylation levelsDebilitating lung diseaseIllumina MethylationEPIC arrayHuman lung tissueEpigenetic ageDNA methylation clocksBiological ageAffected lung tissueIPF casesClinical prognosisMethylation patternsDNA methylationLung diseaseHealthy controlsAcceleration of biological agingMethylation levelsMethylationEPIC arrayAge accelerationClinical assessment
News
News
- August 21, 2024
Unique Immune Profile Identified in Fibrotic Hypersensitivity Pneumonitis
- August 25, 2023
Can Small RNA Inhibitors Reverse Pulmonary Fibrosis?
- May 24, 2023Source: Yale Ventures
Blavatnik Fund for Innovation at Yale Awards $2.5 Million to 11 Faculty-Led Projects
- February 01, 2023
Inhibition of Small RNA in Lung Macrophages May Counter Pulmonary Fibrosis