Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsEdward Ryan, PhD
Associate Clinical ProfessorAbout
Research
Publications
2026
Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh
Akhtar M, Islam M, Khan Z, Akter A, Tauheed I, Ahmed T, Khan I, Amin M, Khaton F, Khanam F, Islam M, Biswas P, Rashid R, Rashid M, Hossain M, Alam A, Alamgir A, Ryan E, Banu S, Shirin T, Chowdhury F, Khan A, Bhuiyan T, Qadri F. Longevity and Magnitude of Antibody Responses After Homologous and Heterologous COVID-19 Booster Vaccinations in Bangladesh. Vaccines 2026, 14: 531. PMID: 42347652, PMCID: PMC13308296, DOI: 10.3390/vaccines14060531.Peer-Reviewed Original ResearchChAdOx1 nCoV-19IgG antibody responsesAntibody responseBooster doseIgG levelsHeterologous boosterMRNA vaccinesNCoV-19IgG responsesVaccination strategiesHomologous boosterMagnitude of antibody responsesSustained IgG responseMRNA-based vaccinesHumoral immune responseLower antibody responsesThird doseCOVID-19 booster vaccinationPrimary dosePost-primary vaccinationImmune responseBooster immunizationVaccine typesBooster vaccinationDoseGlobal Cholera-Control Efforts — Progress and Remaining Challenges
Ryan E, Qadri F, Lynch J. Global Cholera-Control Efforts — Progress and Remaining Challenges. The New England Journal Of Medicine 2026, 394: 2177-2180. PMID: 42253239, DOI: 10.1056/nejmp2600873.Peer-Reviewed Original ResearchEstimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases From Household Microbiological and Clinical Data
Smith C, Lessler J, Hegde S, Bhuiyan T, Islam T, Ahmmed F, Chowdhury F, Khan A, LaRocque R, Charles R, Weil A, Calderwood S, Ryan E, Harris J, Azman A, Qadri F, Wiens K. Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases From Household Microbiological and Clinical Data. Journal Of Infectious Diseases 2026, jiag278. PMID: 42246165, DOI: 10.1093/infdis/jiag278.Peer-Reviewed Original ResearchRisk of infectionRisk of transmissionHousehold contactsAsymptomatic infectionRelative riskProphylactic antibiotic treatmentInfected household contactsSymptomatic individualsAcute watery diarrheaRelative risk of transmissionAntibiotic treatmentHousehold membersFollow-upWatery diarrheaSymptomatic casesCholera casesDaily riskAsymptomatic infected individualsVibriocidal antibodiesMultiple time pointsInfectionSymptom historyCholera treatmentHealth facilitiesTime pointsImproving cholera vaccination impact through advances in gut mucosal immunology: outcomes of a 2025 expert consultation
Lundgren A, Vannice K, Ryan E, Steele D, Holmgren J. Improving cholera vaccination impact through advances in gut mucosal immunology: outcomes of a 2025 expert consultation. Vaccine 2026, 81: 128571. PMID: 42025097, DOI: 10.1016/j.vaccine.2026.128571.Peer-Reviewed Original ResearchConceptsOral cholera vaccineControlled human infection modelMucosal immunologyVaccine impactCholera vaccineEvaluation of immune responsesCholera-endemic settingsHuman infection modelGut mucosal responsesEvaluation of adjuvantsImmune response assaysMucosal responsesEndemic settingsImmune responseInfection modelVaccine efficacyVaccine candidatesResponse assayAge groupsImmunological researchDisease controlImmunologyVaccineLonger-term improvementsYoung childrenMapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply
Ravishankar K, Mace K, Koiso S, Ridpath A, Gulbas E, Thwing J, LaRocque R, Williams S, Ryan E, Brown T, Hyle E. Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply. Clinical Infectious Diseases 2026, ciag139. PMID: 41955078, DOI: 10.1093/cid/ciag139.Peer-Reviewed Original ResearchSevere malaria casesMalaria casesIntravenous artesunateCenters for Disease Control and PreventionSevere malariaLevel 1 trauma centerStandard of careUS Centers for Disease Control and PreventionLife-threatening conditionDisease Control and PreventionControl and PreventionTreatment deliveryMap hospitalsMalariaHospitalHealth system planningGeographical distribution of hospitalsTreatmentArtesunateHealth system strategiesCasesDistribution of hospitalsUnited StatesEffect of containment strategies for respiratory diseases on infections imported via international travel to the USA: a modelling study
Koiso S, Lee H, Ciaranello A, Freedberg K, Ryan E, Jalali M, LaRocque R, Hyle E. Effect of containment strategies for respiratory diseases on infections imported via international travel to the USA: a modelling study. BMJ Open 2026, 16: e105013. PMID: 41708165, PMCID: PMC12918698, DOI: 10.1136/bmjopen-2025-105013.Peer-Reviewed Original Research
2025
Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens
Chac D, Heller F, Banna H, Kaisar M, Markiewicz S, Pruitt E, Chowdhury F, Bhuiyan T, Akter A, Khan A, Dumayas M, Rice A, Karmakar P, Dash P, LaRocque R, Ryan E, Xu L, Minot S, Harris J, Qadri F, Weil A. Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens. Nature Communications 2025, 17: 638. PMID: 41388019, PMCID: PMC12816596, DOI: 10.1038/s41467-025-67388-y.Peer-Reviewed Original ResearchOral cholera vaccineMetagenomic sequencing dataStrain-specific resultsSequence dataMetagenomic sequencingVibrio choleraeFecal microbiotaImmune responseOral vaccine responsesBiological outcomesMicrobiotaHuman macrophagesSphingolipidsVaccine responseVaccine antigensCholera vaccineAntigenBacteroidesBacteriaGutSequenceVaccineDegree of protectionCholeraClinical and environmental wastewater-based bacteriophage surveillance for high-impact diarrheal diseases, including cholera, in Bangladesh
Akhtar M, Amin A, Hussain S, Nafsi N, Parvin N, Khanam F, Islam T, Bhuiyan A, Afroz R, Firoj G, Chowdhury F, Khan A, Jubair M, Ryan E, Shapiro B, Thomson N, Nelson E, Rahman M, Begum Y, Bhuiyan T, Qadri F. Clinical and environmental wastewater-based bacteriophage surveillance for high-impact diarrheal diseases, including cholera, in Bangladesh. MBio 2025, 17: e02654-25. PMID: 41363802, PMCID: PMC12802145, DOI: 10.1128/mbio.02654-25.Peer-Reviewed Original ResearchDiarrheal pathogensBacterial hostsPotential of bacteriophagesEscherichia coliBacterial counterpartsPhage dynamicsPathogen populationsETECDiarrheal patientsPhageDiarrheal specimensHost rangeDiarrheal surveillancePathogensEnvironmental sourcesEarly indicatorBacteriophageDiarrheal diseasePathogen transmissionLt;5 yearsEndemic settingsDiarrhealCholeraHostTransmission dynamicsTravel After Transplant: Demographics, Travel Trends, and Vaccination Practices of US Immunocompromised Travelers
Rolfe R, Rao S, Oliver E, Thwing J, Ryan E, Kotton C, LaRocque R. Travel After Transplant: Demographics, Travel Trends, and Vaccination Practices of US Immunocompromised Travelers. Transplantation 2025, 110: e905-e911. PMID: 41288311, DOI: 10.1097/tp.0000000000005580.Peer-Reviewed Original ResearchTravel trendsPretravel health consultationCruise ship travelControl travelOnline structured questionnaireVaccination practicesTravel patternsTravel itinerariesVisiting friendsTravelHigher-risk populationsPretravel preparationShip travelHealth preparationStem cell transplant recipientsRisk of illnessHealth consultationUS clinical sitesDescriptive statisticsStructured questionnaireClinical sitesMeasles-mumps-rubella vaccineYellow fever vaccineMedian ageTransplant recipientsTravel Healthy, a mobile app for participatory surveillance among U.S. international travelers
Colubri A, Willing N, Grozdani A, Dong Y, Hong H, Khandpekar M, Oliver E, Thwing J, Ryan E, LaRocque R. Travel Healthy, a mobile app for participatory surveillance among U.S. international travelers. Travel Medicine And Infectious Disease 2025, 68: 102922. PMID: 41083032, DOI: 10.1016/j.tmaid.2025.102922.Peer-Reviewed Original Research
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