Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsChirag Parikh, MD, PhD, FACP
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Professor Adjunct
Biography
Dr. Parikh is an Adjunct Professor of Medicine, section of Nephrology. Currently at Johns Hopkins University, Dr. Parikh continues his research projects and collaborations with F. Perry Wilson, MD, MSCE, the Interim Director of the Program of Applied Translational Research (PATR) and with other faculty and collaborators within PATR.
Dr. Parikh received his MD from Mumbai, India in 1996. His post-graduate training involves Residency in Internal Medicine at Nassau University and SUNY in Stony Brook, NY, and Fellowship in Nephrology and Hypertension at the University of Colorado Health Sciences Center in Denver, CO. He also completed a PhD in Clinical Investigation and Translational Research at University of Colorado Health Sciences Center, Denver, CO in 2003. He is board certified in both Internal Medicine and Nephrology. He has received several awards, including the National Junior Physician Investigator Award from the American Federation of Medical Research and the Outstanding Investigator Award from the Society of Clinical Investigation.
Dr. Parikh conducts an active patient-oriented research program investigating the translational and epidemiological aspects of acute kidney injury (AKI) and other kidney related disorders. His major research interest is developing novel biomarkers of AKI. He is the Principal Investigator of the NIH sponsored TRIBE-AKI consortium that is conducting large studies for validating novel kidney injury biomarkers in setting of cardiac surgery, kidney transplantation, diabetic kidney disease and hepatorenal syndrome. He has authored more than 250 peer-reviewed papers, 50 book chapters and reviews, and he has given more than 50 invited lectures at scientific meetings and academic institutions around the world.
Last Updated on April 07, 2025.
Departments & Organizations
Education & Training
- PhD
- University of Colorado at Denver (2003)
- MD
- Seth G.S. Medical College (1996)
Research
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Overview
Medical Research Interests
Acute Kidney Injury; Biomarkers, Pharmacological; Biostatistics; Kidney Diseases; Nephrology; Renal Insufficiency; Translational Research, Biomedical
Public Health Interests
Biomarkers
ORCID
0000-0001-9051-7385
Research at a Glance
Yale Co-Authors
Frequent collaborators of Chirag Parikh's published research.
Publications Timeline
A big-picture view of Chirag Parikh's research output by year.
Research Interests
Research topics Chirag Parikh is interested in exploring.
F. Perry Wilson, MD, MSCE
Dennis G Moledina, MD, PhD, FASN
Jason Greenberg, MD, MHS
Sherry Mansour, MD, MS, DO
Justin Belcher, MD, PhD, FASN
Lloyd G. Cantley, MD
156Publications
4,014Citations
Acute Kidney Injury
Kidney Diseases
Renal Insufficiency
Publications
2026
Integrating clinical decision support systems in chronic kidney disease management
Cervantes C, Philbrook H, Bitzel J, Patel D, Menez S, Srialluri N, Sang Y, Scott J, Jaar B, Grams M, Parikh C. Integrating clinical decision support systems in chronic kidney disease management. Kidney International Reports 2026, 106633. DOI: 10.1016/j.ekir.2026.106633.Peer-Reviewed Original ResearchMetabolomic Signatures of Inflammation in Chronic Kidney Disease
Chen T, Surapaneni A, Estrella M, Appel L, Obeid W, Parikh C, Rooney M, Yu B, Rhee E, Schmidt I, Waikar S, Grams M. Metabolomic Signatures of Inflammation in Chronic Kidney Disease. Kidney Medicine 2026, 101458. DOI: 10.1016/j.xkme.2026.101458.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseEpidermal growth factorKidney diseaseInflammatory proteinsBlood levelsMetabolomic signaturesIFN-gCross-sectional associationsAssociated with adverse kidneyLevels of tumor necrosis factor receptor 1IL-8Low 1,5-anhydroglucitolSignatures of inflammationTumor necrosis factor receptor 1Prospective cohort settingLongitudinal changesBaseline blood levelsAdverse kidneyInflammatory markersInterferon-gammaCardiovascular riskIL-10Multivariate linear regressionMetabolic milieuDisease progressionLow cardiac index during periods of arterial hypotension and risk of acute kidney injury in cardiac surgery
Goeddel L, Koffman L, Zhou X, Hernandez M, Zhao A, Pasrija C, Saha A, Muschelli J, Parikh C, Crainiceanu C, Brown C, Khanna A, Faraday N. Low cardiac index during periods of arterial hypotension and risk of acute kidney injury in cardiac surgery. British Journal Of Anaesthesia 2026 PMID: 42097957, DOI: 10.1016/j.bja.2026.02.037.Peer-Reviewed Original ResearchAltmetricConceptsAssociated with acute kidney injuryAssociated with AKIMean arterial pressureLength of stayCardiac indexAcute kidney injuryCardiac surgeryDuration of hypotensionKidney injuryRisk of AKIOdds ratioRisk of acute kidney injuryIntraoperative mean arterial pressureLow cardiac indexHospital length of stayJoint rangeProspective intervention trialPeriod of hypotensionCardiopulmonary bypassRenal perfusionArterial hypotensionArterial pressureClinical trialsHypotensionSecondary outcomesIndependent association between acute kidney injury and kidney function trajectory
Prado V, McCoy I, Zhang Y, Hsu J, Liu K, Muiru A, Chinchilli V, Coca S, Go A, Himmelfarb J, Kaufman J, Kimmel P, Ikizler T, Parikh C, Siew E, Wurfel M, Hsu C. Independent association between acute kidney injury and kidney function trajectory. Kidney International 2026, 110: 206-213. PMID: 42034199, DOI: 10.1016/j.kint.2026.03.013.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMild to moderate acute kidney injuryModerate acute kidney injuryAcute kidney injuryKidney injuryKidney functionEpisodes of acute kidney injuryKidney function trajectoriesLoss of kidney functionTrajectories of estimated glomerular filtration rateSequelae of acute kidney injuryGlomerular filtration rateFunction trajectoriesKidney disease progressionLinear mixed-effects regression modelsMixed-effects regression modelsEGFR slopeSerum creatininePublic health importanceCystatin CFiltration rateDisease progressionPotential confoundersIndependent associationsEGFRASSESS-AKIDevelopment and Validation of Machine Learning Models to Identify Emergency Department Patients at Increased Risk of New or Progressive Acute Kidney Injury
Hinson J, Zhao X, Ehmann M, Copenhaver M, Shpitser I, Menez S, Parikh C, Strauss A, Kelen G, Badaki-Makun O, Levin S, Klein E. Development and Validation of Machine Learning Models to Identify Emergency Department Patients at Increased Risk of New or Progressive Acute Kidney Injury. Journal Of The American College Of Emergency Physicians Open 2026, 7: 100397. PMID: 42016808, PMCID: PMC13094641, DOI: 10.1016/j.acepjo.2026.100397.Peer-Reviewed Original ResearchConceptsEmergency departmentED visitsProgressive acute kidney injuryAcute kidney injuryOutcome dataHealth-care systemSerum creatinine-based criteriaEmergency department patientsInverse probability weightingAccurate risk estimatesED careED departureED sitesMeasures of diagnostic performanceCreatinine-based criteriaMulticenter studyAdult patientsKidney injuryStudy of adult patientsDepartment patientsMulticenter study of adult patientsMultiple imputationRisk estimatesKidney diseaseED dataOperational checks for real-time urinary biomarker measurements for assessment of the quality of deceased donor kidneys
Barik M, DSouza S, Obeid W, Hu D, Xu S, Doshi M, Mohan S, Gansner E, Marklin G, Olden N, Woodard W, Herczyk W, Philbrook H, Parikh C. Operational checks for real-time urinary biomarker measurements for assessment of the quality of deceased donor kidneys. Scientific Reports 2026, 16: 17731. PMID: 41992046, PMCID: PMC13247077, DOI: 10.1038/s41598-026-48155-5.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammation and risk of adverse events in patients with cirrhosis.
Puthumana J, Belcher J, Garcia-Tsao G, Ix J, Obeid W, Sanyal A, Parikh C. Biomarkers of inflammation and risk of adverse events in patients with cirrhosis. Liver Transplantation 2026 PMID: 41894248, DOI: 10.1097/lvt.0000000000000862.Peer-Reviewed Original ResearchCitationsAltmetricConceptsUrine monocyte chemoattractant protein-1Monocyte chemoattractant protein-1Acute kidney injuryIn-Hospital ComplicationsAcute kidney injury progressionTNFR-1Inflammatory biomarkersPlasma tumor necrosis factor-receptor 1Odds ratioUrine YKL-40Spontaneous bacterial peritonitisTumor necrosis factor receptor 1High-risk patientsRisk of adverse eventsTertiary care centerBaseline kidney functionBiomarkers of inflammationProspective cohort studyChemoattractant protein-1Variceal bleedingBacterial peritonitisSevere complicationsMELD scoreKidney injuryAdverse eventsAssociations between exposure to polycyclic aromatic hydrocarbons and biomarkers of acute kidney injury among chilean agricultural workers
Tore G, DeSantiago M, Stapleton H, Obeid W, Parikh C, Kuiper J, Valenzuela M, Ferreccio C, Fazen L, Dickerson A, Cortés S, Quirós-Alcalá L. Associations between exposure to polycyclic aromatic hydrocarbons and biomarkers of acute kidney injury among chilean agricultural workers. International Journal Of Hygiene And Environmental Health 2026, 274: 114791. PMID: 41880841, PMCID: PMC13140096, DOI: 10.1016/j.ijheh.2026.114791.Peer-Reviewed Original ResearchConceptsPolycyclic aromatic hydrocarbonsPolycyclic aromatic hydrocarbon exposureAromatic hydrocarbonsParent polycyclic aromatic hydrocarbonsExposure to polycyclic aromatic hydrocarbonsUrinary polycyclic aromatic hydrocarbonsParent PAH compoundsConcentration of anthraceneInterquartile range increasePAH compoundsAssociated with higher urinary concentrationsHydroxy-PAHsExposure concentrationsRange increaseHigher urinary concentrationsUrinary concentrationsKnowledge gapsHydrocarbonsAgricultural communitiesConcentrationExposureChrysenePhenanthreneBenzo[e]pyreneBenzo[a]pyreneLow Urine Uromodulin Levels are Associated With Interstitial Fibrosis and Tubular Atrophy in Native Kidney Biopsies
Parikh M, Philbrook H, Hu D, Bitzel J, Xue J, DSouza S, Rosenberg A, Moledina DG, Coca S, Parikh C, Menez S, Project K. Low Urine Uromodulin Levels are Associated With Interstitial Fibrosis and Tubular Atrophy in Native Kidney Biopsies. Kidney International Reports 2026, 11: 106351. PMID: 41883681, PMCID: PMC13010425, DOI: 10.1016/j.ekir.2026.106351.Peer-Reviewed Original ResearchAltmetricConcordance of Prebiopsy and Postbiopsy Diagnosis in Hospitalized Patients with Acute Kidney Injury
McGredy M, Hu D, Philbrook H, Corona-Villalobos C, Rosenberg A, Moledina DG, Coca S, Parikh C, Menez S. Concordance of Prebiopsy and Postbiopsy Diagnosis in Hospitalized Patients with Acute Kidney Injury. Kidney360 2026, 7: 1027-1033. PMID: 41671053, PMCID: PMC13229441, DOI: 10.34067/kid.0000001151.Peer-Reviewed Original ResearchAltmetricConceptsAcute interstitial nephritisAcute tubular injuryPre-biopsy clinical diagnosisFocal segmental glomerulosclerosisPercutaneous kidney biopsyKidney biopsyClinical diagnosisPre-biopsyPost-biopsyClinical diagnosis of acute interstitial nephritisDiagnosis of acute interstitial nephritisGlomerular diseaseAcute kidney injuryNon-invasive testsJohns Hopkins HospitalFinal diagnosisAbsolute contraindicationAdult patientsKidney injuryTubular injuryAlternative diagnosesHistological findingsBiopsyInterstitial nephritisDiabetic nephropathy
Academic Achievements & Community Involvement
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Honors
honor Jeff Gray Memorial "Translating to Management in AKI"
03/09/2017National AwardAKI and CRRT 2017 22nd International ConferenceDetailsUnited Stateshonor Dr. MD Motashaw Oration and Award for Research Accomplishment
04/24/2013International AwardSeth G.S. Medical College and KEM HospitalDetailsIndia
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