Andrew Solomon, PhD
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Research
Publications
2026
Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study
Scharf A, Cohen J, Marrie R, Miller A, Waubant E, Kilbane M, Luskin E, Azevedo C, Dever M, Alvarez E, Calabresi P, Chahin S, Freeman L, Nakamura K, Longbrake E, Mowry E, Oh J, Rodrigues P, Ramos M, Sotirchos E, Cutter G, Kaisey M, Amin M, Toljan K, Illenberger N, Bilello M, Lee J, Maya M, Obusez E, Schindler M, Suthiphosuwan S, Ulano A, Shinohara R, Reich D, Solomon A, Sicotte N, Sati P, Ontaneda D. Application of the 2024 McDonald Criteria in Individuals With Nonspecific Symptoms or Incidental Imaging Findings in a Multicenter Study. Neurology 2026, 107: e218183. PMID: 42284534, PMCID: PMC13267864, DOI: 10.1212/wnl.0000000000218183.Peer-Reviewed Original ResearchConceptsIncidental imaging findingsCSF oligoclonal bandsCentral vein signOligoclonal bandsMcDonald criteriaImaging findingsMultiple sclerosisDiagnostic yieldNonspecific symptomsPositive oligoclonal bandsMulticenter observational cohortSubacute cognitive declineDiagnosis of multiple sclerosisDiagnosis of MSPost Hoc AnalysisLongitudinal Follow-upMRI criteriaBiological mechanismsVisual disturbancesMulticenter cohortMulticenter studyFollow-upMechanisms of diseaseSensory symptomsObservational cohortDiagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis
Toljan K, Renner B, Daboul L, Martin M, Cao Q, O'Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Nakamura K, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. Diagnostic performance of central vein sign and paramagnetic rim lesion integration for multiple sclerosis. Multiple Sclerosis Journal 2026, 32: 614-623. PMID: 42010983, PMCID: PMC13138446, DOI: 10.1177/13524585261434218.Peer-Reviewed Original ResearchConceptsCentral vein signParamagnetic rim lesionsDiagnostic performanceClinical/radiological suspicionMultiple sclerosisDiagnostic evaluationSuspicion of MSCerebrospinal fluid testingEvaluation of MSMagnetic resonance imagingOligoclonal bandsBiomarkers of multiple sclerosisMcDonald criteriaRim lesionsDiagnostic specificityFluid testingResonance imagingReference standardNeuroimaging biomarkersDiagnostic biomarkersSensitivity/specificitySclerosisSignsSuperior visibility of paramagnetic rim lesions on filtered phase versus SWI.
Lee J, Renner B, Madhusoodhanan Nair S, Nakamura K, Luskin E, Shinohara R, Reich D, Solomon A, Sicotte N, Ontaneda D, Sati P. Superior visibility of paramagnetic rim lesions on filtered phase versus SWI. American Journal Of Neuroradiology 2026, ajnr.a9295. PMID: 41826064, DOI: 10.3174/ajnr.a9295.Peer-Reviewed Original ResearchParamagnetic rim lesionsPooled cohortMultiple sclerosisRim lesionsT2 hyperintense lesionsMulticenter observational studySuperior visibilityPrimary cohortMcDonald criteriaDiagnostic evaluationBrain MRI sequencesSecondary cohortMcNemar testObservational studyImaging biomarkersNodular appearanceCohortLesionsMRI sequencesClinical practiceClinical settingFiltered phase imagesPhase imagesStudy sampleSWIAccess and barriers to diagnosis of multiple sclerosis in Iran - A clinician survey
Khodadadi S, Bahrami S, Jahani S, Sahraian M, Solomon A. Access and barriers to diagnosis of multiple sclerosis in Iran - A clinician survey. Multiple Sclerosis And Related Disorders 2026, 109: 107089. PMID: 41832843, DOI: 10.1016/j.msard.2026.107089.Peer-Reviewed Original ResearchGeneral neurologistsMS diagnosisOptical coherence tomographyDiagnosis of multiple sclerosisVisual evoked potentialsHealthcare professional educationCross-sectional studyPerspectives of neurologistsMultiple sclerosisTimely diagnosisHealthcare providersResource-limited settingsTargeted educationPatient reluctanceNational guidelinesMS specialistsAQP4-IgG testingSocial stigmaMS symptomsAdequate resourcesMOG-IgGAQP4-IgGProfessional educationMcDonald criteriaCoherence tomographyAre neurofilament light chain levels ready for routine clinical use? – No
Sotirchos E, Solomon A. Are neurofilament light chain levels ready for routine clinical use? – No. Multiple Sclerosis Journal 2026, 32: 673-675. PMID: 41711385, DOI: 10.1177/13524585261423029.Peer-Reviewed Original ResearchComparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort
Toljan K, Amin M, Daboul L, Nakamura K, Solomon A, Sicotte N, Shinohara R, Reich D, Sati P, Ontaneda D. Comparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort. European Journal Of Radiology 2026, 196: 112707. PMID: 41628503, DOI: 10.1016/j.ejrad.2026.112707.Peer-Reviewed Original ResearchConceptsCentral vein signMultiple sclerosisPost-contrast FLAIRT2 hyperintense lesionsDiagnosis of MSDetection of lesionsHyperintense lesionsCentral hypointensityDiagnostic cohortLesion rateLow specificityDiagnostic specificityFLAIR imagesHypointensityLesionsMRI sequencesFLAIRBlinded ratersConcurrent detection
2025
Lipoic Acid for Treatment of Progressive Multiple Sclerosis
Spain R, Paz Soldán M, Freedman M, Repovic P, Solomon A, Rinker J, Wallin M, Haselkorn J, Stuve O, Gross R, Waslo C, Hildebrand A, Morris C, Mitchell J, Turner A, Schwartz D, Metz J, Rooney W. Lipoic Acid for Treatment of Progressive Multiple Sclerosis. Neurology 2025, 106: e214454. PMID: 41397213, PMCID: PMC12714125, DOI: 10.1212/wnl.0000000000214454.Peer-Reviewed Original ResearchConceptsLA participantsDisease-modifying therapiesSecondary progressive MSExpanded Disability Status ScaleProgressive MSProgressive multiple sclerosisWalking speedAdverse eventsBrain atrophyGray matter volumeMultiple sclerosisLA groupT2-weighted lesion volumeWhole-brain volumePlacebo-controlled clinical trialTreatment of progressive multiple sclerosisDeep gray matter volumesTimed 25-Foot WalkIntention-to-treat analysisPatient-reported disabilityVeterans Affairs Medical CenterWhole-brain atrophyClass II evidenceMedian EDSS scoreMatter volumeThe revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: Yes
Ramanathan S, Solomon A. The revised 2024 McDonald criteria can solve the misdiagnosis problem in multiple sclerosis: Yes. Multiple Sclerosis Journal 2025, 32: 163-164. PMID: 41388897, DOI: 10.1177/13524585251396284.Peer-Reviewed Original ResearchDiagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria
Montalban X, Lebrun-Frénay C, Oh J, Arrambide G, Moccia M, Pia Amato M, Amezcua L, Banwell B, Bar-Or A, Barkhof F, Butzkueven H, Ciccarelli O, Chataway J, Cohen J, Comi G, Correale J, Deisenhammer F, Filippi M, Fiol J, Freedman M, Fujihara K, Granziera C, Green A, Hartung H, Hellwig K, Kappos L, Kimbrough D, Killestein J, Lublin F, Marignier R, Marrie R, Miller A, Otero-Romero S, Ontaneda D, Ramanathan S, Reich D, Rocca M, Rovira À, Saidha S, Salter A, Sastre-Garriga J, Saylor D, Solomon A, Sormani M, Stankoff B, Tintore M, Tremlett H, Van der Walt A, Viswanathan S, Wiendl H, Wildemann B, Yamout B, Zaratin P, Calabresi P, Coetzee T, Thompson A. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. The Lancet Neurology 2025, 24: 850-865. PMID: 40975101, DOI: 10.1016/s1474-4422(25)00270-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiagnosis of multiple sclerosisMultiple sclerosisMcDonald criteriaFree light chain concentrationsRadiologically isolated syndromeMcDonald diagnostic criteriaCentral vein signParamagnetic rim lesionsProgression of disabilityMultiple sclerosis diagnosisOptic nerveNeurological symptomsProgressive courseRim lesionsAnatomical locationDiagnostic criteriaDiagnosisRevision criteriaSclerosisOlder individualsSupportive evidenceThe 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis
Solomon A, Brodersen J. The 2024 revisions of the McDonald criteria pose risk of multiple sclerosis overdiagnosis. Nature Reviews Neurology 2025, 21: 659-660. PMID: 40962996, DOI: 10.1038/s41582-025-01140-4.Peer-Reviewed Original Research
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