2011
Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters
Kerestes R, Ladouceur CD, Meda S, Nathan PJ, Blumberg HP, Maloney K, Ruf B, Saricicek A, Pearlson GD, Bhagwagar Z, Phillips ML. Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters. Psychological Medicine 2011, 42: 29-40. PMID: 21733287, DOI: 10.1017/s0033291711001097.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexNegative emotional informationFunctional magnetic resonance imagingEmotional distractersAttentional controlEmotional informationMemory taskMemory loadEmotional Face N-Back (EFNBACK) taskOrbitofrontal cortexNegative emotional distractersN-back taskInterface of cognitionAccurate task performanceKey neural circuitsBlood oxygen level-dependent functional magnetic resonance imagingRMDD patientsLevel-dependent functional magnetic resonance imagingAttentional biasesFacial emotionsEmotion processingDepressed patientsDistracter stimuliTrait-like abnormalitiesRight DLPFC
2009
Enhanced Visual Motion Perception in Major Depressive Disorder
Golomb JD, McDavitt JR, Ruf BM, Chen JI, Saricicek A, Maloney KH, Hu J, Chun MM, Bhagwagar Z. Enhanced Visual Motion Perception in Major Depressive Disorder. Journal Of Neuroscience 2009, 29: 9072-9077. PMID: 19605644, PMCID: PMC2772577, DOI: 10.1523/jneurosci.1003-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceContrast SensitivityDepressive Disorder, MajorDiscrimination LearningDiscrimination, PsychologicalHumansMotion PerceptionNeuropsychological TestsOrientationPattern Recognition, VisualPhotic StimulationPsychophysicsReaction TimeSensory ThresholdsVisual AcuityYoung AdultConceptsSpatial suppressionMotion perceptionLarge high-contrast stimuliMotion discrimination taskVisual motion perceptionMajor depressive disorderGreater lifetime durationHigh-contrast stimuliPerceptual discriminationHealthy young adultsVisual processingDiscrimination taskTime of testingTrait vulnerabilityPsychophysical performanceCounterintuitive hypothesisEndophenotypic markerVisual systemProcessing tasksMood symptomsOccipital cortexDepressive disorderYoung adultsVisual pathwayCortical level