2010
Increased peripheral blood expression of electron transport chain genes in bipolar depression
Beech RD, Lowthert L, Leffert JJ, Mason PN, Taylor MM, Umlauf S, Lin A, Lee JY, Maloney K, Muralidharan A, Lorberg B, Zhao H, Newton SS, Mane S, Epperson CN, Sinha R, Blumberg H, Bhagwagar Z. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disorders 2010, 12: 813-824. PMID: 21176028, PMCID: PMC3076072, DOI: 10.1111/j.1399-5618.2010.00882.x.Peer-Reviewed Original ResearchConceptsBipolar disorderBipolar depressionPeripheral bloodDepressed subjectsGeneGo MetaCore softwarePeripheral blood expressionHealthy control subjectsReal-time reverse transcription-polymerase chain reactionEffects of medicationReverse transcription-polymerase chain reactionQuantitative real-time reverse transcription-polymerase chain reactionTranscription-polymerase chain reactionMitochondrial electron transport chainControl subjectsPolymerase chain reactionUnmedicated subjectsHealthy controlsBlood expressionBPD subjectsSpecific genetic pathwaysElectron transport chain genesMetaCore softwareA totalAltered expressionQRT-PCR
2004
Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635
Bhagwagar Z, Rabiner E, Sargent P, Grasby P, Cowen P. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Molecular Psychiatry 2004, 9: 386-392. PMID: 15042104, DOI: 10.1038/sj.mp.4001401.Peer-Reviewed Original ResearchConceptsMajor depressionDepressed menDepressed subjectsAcute major depressionPositron emission tomography studyPotentials of brainEmission tomography studiesRecurrent major depressionPositron emission tomographyStatistical parametric mappingReceptor BPReference tissue modelAntidepressant medicationPersistent dysfunctionRaphe nucleusUnmedicated subjectsHealthy controlsBP valuesCortical areasTrait abnormalityMale subjectsEmission tomographyPersistent reductionTomography studyReceptor binding
2002
State and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission