2011
Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters
Kerestes R, Ladouceur CD, Meda S, Nathan PJ, Blumberg HP, Maloney K, Ruf B, Saricicek A, Pearlson GD, Bhagwagar Z, Phillips ML. Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters. Psychological Medicine 2011, 42: 29-40. PMID: 21733287, DOI: 10.1017/s0033291711001097.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexNegative emotional informationFunctional magnetic resonance imagingEmotional distractersAttentional controlEmotional informationMemory taskMemory loadEmotional Face N-Back (EFNBACK) taskOrbitofrontal cortexNegative emotional distractersN-back taskInterface of cognitionAccurate task performanceKey neural circuitsBlood oxygen level-dependent functional magnetic resonance imagingRMDD patientsLevel-dependent functional magnetic resonance imagingAttentional biasesFacial emotionsEmotion processingDepressed patientsDistracter stimuliTrait-like abnormalitiesRight DLPFC
2008
Lower brain serotonin transporter binding potential in unipolar acutely depressed patients — A preliminary [11C]DASB PET study
Selvaraj S, Murthy V, Bhagwagar Z, Bose S, Cowen P, Grasby P. Lower brain serotonin transporter binding potential in unipolar acutely depressed patients — A preliminary [11C]DASB PET study. NeuroImage 2008, 41: t167. DOI: 10.1016/j.neuroimage.2008.04.134.Peer-Reviewed Original Research
2004
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews P, Cowen P. Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor. American Journal Of Psychiatry 2004, 161: 368-370. PMID: 14754790, DOI: 10.1176/appi.ajp.161.2.368.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidBrain GABA concentrationsAcute administrationGABA concentrationSelective serotonin reuptake inhibitor citalopramSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitor citalopramCortical gamma-aminobutyric acidActions of SSRIsGABA/creatine ratiosReuptake inhibitor citalopramSerotonin reuptake inhibitorsGABA neuronsSSRI treatmentReuptake inhibitorsIntravenous citalopramDepressed patientsCreatine ratioHealthy volunteersCortical levelOccipital cortexCrossover designMean increaseMagnetic resonance spectroscopyMood improvement
2003
Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
Bhagwagar Z, Montgomery A, Grasby P, Cowen P. Lack of effect of a single dose of hydrocortisone on serotonin1A receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635. Biological Psychiatry 2003, 54: 890-895. PMID: 14573316, DOI: 10.1016/s0006-3223(03)00466-9.Peer-Reviewed Original ResearchConceptsReceptor BPMajor depressionPositron emission tomographySerotonin-1A receptor bindingEmission tomographyPositron emission tomography scanAcute major depressionEmission tomography scanCertain brain areasElevated cortisol levelsLack of effectCortisol hypersecretionAcute administrationSingle doseHydrocortisone treatmentDepressed patientsTomography scanHealthy volunteersBrain areasCrossover designCortisol levelsSerotonin1A receptorsMale subjectsFemale subjectsPatientsIncrease in Concentration of Waking Salivary Cortisol in Recovered Patients With Depression
Bhagwagar Z, Hafizi S, Cowen P. Increase in Concentration of Waking Salivary Cortisol in Recovered Patients With Depression. American Journal Of Psychiatry 2003, 160: 1890-1891. PMID: 14514508, DOI: 10.1176/appi.ajp.160.10.1890.Peer-Reviewed Original ResearchConceptsSalivary cortisol levelsCortisol levelsDepressed patientsAcute major depressionComorbid medical conditionsHPA axis abnormalitiesWithdrawal of medicationCoronary heart diseaseElevated plasma cortisol levelsHPA axis activityHealthy comparison subjectsPlasma cortisol levelsHealthy comparison groupClinical recoveryAxis abnormalitiesRecovered patientsAdrenal axisFurther episodesAxis activityHeart diseaseMajor depressionMedical conditionsComparison subjectsPatientsDepressed subjectsRisperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients.
Sharpley A, Bhagwagar Z, Hafizi S, Whale W, Gijsman H, Cowen P. Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients. The Journal Of Clinical Psychiatry 2003, 64: 192-6. PMID: 12633128, DOI: 10.4088/jcp.v64n0212.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAntidepressive AgentsAntipsychotic AgentsCross-Over StudiesDepressive DisorderDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedPersonality InventoryPlacebosPolysomnographyPsychiatric Status Rating ScalesRisperidoneSleep, REMTreatment OutcomeWakefulnessConceptsRapid eye movement (REM) sleepEye movement sleepDepressed patientsHealthy volunteersRisperidone treatmentMovement sleepREM sleepMedication-resistant depressed patientsTreatment-resistant depressed patientsConventional antidepressant medicationAntidepressant-like effectsAntipsychotic agent risperidoneDepression Rating ScaleMajor depressive disorderDSM-IV criteriaPatients meritRisperidone additionRisperidone augmentationAntidepressant medicationRisperidone administrationSingle doseTherapeutic dosesAugmentation agentsDepressive disorderHealthy subjects
2002
Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients
Bhagwagar Z, Hafizi S, Cowen P. Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients. Journal Of Affective Disorders 2002, 72: 249-255. PMID: 12450642, DOI: 10.1016/s0165-0327(01)00467-0.Peer-Reviewed Original ResearchConceptsGrowth hormone releaseDepressed patientsMajor depressionHormone releaseStress-induced cortisol secretionBrain serotonin functionPlasma GH levelsEffects of cortisolEffect of hydrocortisoneCross-over designStressful life eventsGH responseGH levelsSingle doseCortisol secretionGH releaseHealthy controlsSerotonin functionRecurrent depressionTRP infusionHealthy volunteersCortisol modulationDepressive symptomatologyDepressed subjectsEuthymic subjectsAcute administration of citalopram facilitates memory consolidation in healthy volunteers
Harmer C, Bhagwagar Z, Cowen P, Goodwin G. Acute administration of citalopram facilitates memory consolidation in healthy volunteers. Psychopharmacology 2002, 163: 106-110. PMID: 12185407, DOI: 10.1007/s00213-002-1151-x.Peer-Reviewed Original ResearchConceptsMemory consolidationCognitive actionsLong-term memory performanceAuditory Verbal Learning TestRecall/recognitionVerbal Learning TestVerbal memory testsSustained attention performanceFacilitate memory consolidationAttention performanceMemory testImmediate recallLearning TestMemory performanceCognitive functionMemory deficitsInformation processingGroups of subjectsSerotonergic neurotransmissionGroup designRecallNon-specific increaseSuccessful pharmacological treatmentDepressed patientsSymptom improvementState and trait abnormalities in serotonin function in major depression
Bhagwagar Z, Whale R, Cowen P. State and trait abnormalities in serotonin function in major depression. The British Journal Of Psychiatry 2002, 180: 24-28. PMID: 11772847, DOI: 10.1192/bjp.180.1.24.Peer-Reviewed Original ResearchConceptsCortisol responseHealthy controlsMajor depressionSerotonin functionRecovered subjectsAdrenal axis dysfunctionBrain serotonin functionPlacebo-controlled designMarker of vulnerabilityAxis dysfunctionClinical recoveryReuptake inhibitorsUnmedicated subjectsProlactin responseDepressed patientsEndocrine responsesNeuroendocrine studiesDepressed subjectsCitalopramDepressionPatientsSubjectsResponseDysfunctionNeurotransmission
2001
Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low
Rabiner E, Bhagwagar Z, Gunn R, Sargent P, Bench C, Cowen P, Grasby P. Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low. American Journal Of Psychiatry 2001, 158: 2080-2082. PMID: 11729033, DOI: 10.1176/appi.ajp.158.12.2080.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDepressive Disorder, MajorDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansMaleMiddle AgedPindololReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsTomography, Emission-ComputedTreatment OutcomeConceptsPositron emission tomographyDose of pindololClinical trialsDepressed patientsSelective serotonin reuptake inhibitorsSignificant occupancyPresent clinical trialSerotonin reuptake inhibitorsPindolol augmentationAntidepressant medicationReuptake inhibitorsPET evidenceEmission tomographyPindololTrialsDoseAutoreceptorsMedicationsPatientsInconsistent resultsEfficacyVast majorityDoses