2001
Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy
Kain Z, Sevarino F, Rinder C, Pincus S, Alexander G, Ivy M, Heninger G. Preoperative Anxiolysis and Postoperative Recovery in Women Undergoing Abdominal Hysterectomy. Anesthesiology 2001, 94: 415-422. PMID: 11374599, DOI: 10.1097/00000542-200103000-00009.Peer-Reviewed Original ResearchConceptsMorning of surgeryAbdominal hysterectomyPostoperative painAnalgesia useTreatment groupsGroup differencesLate postoperative time pointsPatient-controlled analgesia consumptionSelf-reported postoperative painPatient-controlled analgesia usePostoperative clinical courseTime pointsPostoperative time pointsMillions of patientsMinimal beneficial effectsLittle objective dataAnalgesic consumptionRecovery parametersAnalgesia consumptionIntramuscular midazolamPostoperative outcomesPostoperative periodPostoperative recoveryAbdominal surgeryClinical course
2000
Attenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgery