2012
Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation
Shi X, Wang J, Yang Y, Ren Y, Zhou J, Li D. Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. Acta Biochimica Et Biophysica Sinica 2012, 44: 450-454. PMID: 22427462, DOI: 10.1093/abbs/gms017.Peer-Reviewed Original ResearchMeSH KeywordsCell Cycle ProteinsCentrosomeHumansMicrotubule-Associated ProteinsMicrotubule-Organizing CenterMicrotubulesConceptsCentrosomal proteinsMicrotubule assemblyMajor microtubule-organizing centerNovel centrosomal proteinDynamic cytoskeletal polymersMicrotubule-organizing centerMicrotubule elongationEukaryotic cellsMammalian cellsAnimal cellsMolecular detailsCep70Microtubule nucleationMolecular mechanismsCytoskeletal polymersMicrotubule lengthProteinMicrotubule numberAssemblyCellsCentrosomesElongationMicrotubulesMicrotubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity
Sun X, Li D, Yang Y, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. Microtubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity. The Journal Of Pathology 2012, 226: 666-673. PMID: 21989536, DOI: 10.1002/path.3026.Peer-Reviewed Original ResearchConceptsBreast cancerPaclitaxel sensitivityPaclitaxel-containing chemotherapyActivity of paclitaxelBreast cancer correlatesCaspase-3 activity analysisBreast cancer cell linesBreast cancer cellsAbility of paclitaxelCancer cell linesCell proliferation assaysCancer correlatesPathological responsePaclitaxelProliferation assaysCell cycle progressionCancer cellsClinical samplesMitotic indexCell linesCancerMicrotubule-dependent mechanismCycle progressionDrug paclitaxelMicrotubule-binding protein
2011
Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner
Li D, Xie S, Ren Y, Huo L, Gao J, Cui D, Liu M, Zhou J. Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner. Protein & Cell 2011, 2: 150-160. PMID: 21359602, PMCID: PMC4875255, DOI: 10.1007/s13238-011-1015-4.Peer-Reviewed Original ResearchConceptsHistone deacetylase 6Molecular mechanismsCell migrationEB1-dependent mannerEndothelial cell migrationCell motilityNovel playerCapillary-like structuresEndothelial cellsEndothelial tube formationNew capillary vesselsCell polarizationHDAC6 activityMicrotubule endsNew blood vesselsNovel insightsProtein 1Vascular endothelial cellsTube formationBlood vasculatureCapillary sproutingAngiogenic processChick embryosAngiogenesisImportant process