Young-Ri Shim
Postdoctoral AssociateAbout
Research
Publications
2026
Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration
Shim Y, Kim H, Kim M, Lee J, Kim K, Choi S, Chung K, Lee E, Lee K, Byun J, Oh J, Han J, Byun J, Park J, Kim W, Lee Y, Jeong W. Glutamate excreted by LepR⁺ BM-MSCs mitigates alcohol-associated liver disease by promoting IL-1R2⁺ monocyte migration. Clinical And Molecular Hepatology 2026 PMID: 42315151, DOI: 10.3350/cmh.2026.0425.Peer-Reviewed Original Research
2025
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Yang K, Kim K, Ryu T, Shim Y, Kim H, Choi S, Kim M, Chung K, Lee E, Lee K, Jeon J, Kim P, Kim Y, Ku T, Jeong H, Nam K, Lim G, Choi D, Kim S, Eun H, Kim W, Jeong W. Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells. Nature Communications 2025, 16: 5546. PMID: 40595616, PMCID: PMC12216207, DOI: 10.1038/s41467-025-60820-3.Peer-Reviewed Original Research
2024
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Hong S, Kim K, Shim Y, Park J, Choi S, Min H, Lee S, Song J, Kang S, Jeong W, Seong R, Kim S. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex. Cell Communication And Signaling 2024, 22: 526. PMID: 39478550, PMCID: PMC11524019, DOI: 10.1186/s12964-024-01907-0.Peer-Reviewed Original ResearchCX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression
Jeong J, Choi S, Shim Y, Kim H, Lee Y, Yang K, Kim K, Kim M, Chung K, Kim S, Byun J, Eun H, Jeong W. CX3CR1+ macrophages interact with HSCs to promote HCC through CD8+ T-cell suppression. Hepatology 2024, 82: 655-668. PMID: 40833997, PMCID: PMC12356560, DOI: 10.1097/hep.0000000000001021.Peer-Reviewed Original Research
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
Kim H, Shim Y, Kim H, Yang K, Ryu T, Kim K, Choi S, Kim M, Woo C, Chung K, Hong S, Shin H, Suh J, Jung Y, Hwang G, Kim W, Kim S, Eun H, Seong J, Jeong W. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original ResearchComprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease
Yang K, Kim H, Shim Y, Ryu T, Kim C. Comprehensive transcriptomic analysis and meta-analysis identify therapeutic effects of N-acetylcysteine in nonalcoholic fatty liver disease. Frontiers In Pharmacology 2023, 14: 1186582. PMID: 37256235, PMCID: PMC10225598, DOI: 10.3389/fphar.2023.1186582.Peer-Reviewed Original ResearchExosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice
Kim H, Shim Y, Choi S, Falana T, Yoo J, Ahn S, Park M, Seo H, Choi C, Jeong W. Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice. Pharmaceutics 2023, 15: 636. PMID: 36839957, PMCID: PMC9965399, DOI: 10.3390/pharmaceutics15020636.Peer-Reviewed Original ResearchThe Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies
Yang K, Kim H, Shim Y, Song M. The Efficacy of Panax ginseng for the Treatment of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies. Nutrients 2023, 15: 721. PMID: 36771427, PMCID: PMC9919883, DOI: 10.3390/nu15030721.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCatecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Kim H, Shim Y, Choi S, Kim M, Lee G, You H, Choi W, Yang K, Ryu T, Kim K, Kim M, Woo C, Chung K, Hong S, Eun H, Kim S, Ko G, Park J, Gao B, Kim W, Jeong W. Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. Experimental & Molecular Medicine 2023, 55: 158-170. PMID: 36631664, PMCID: PMC9898237, DOI: 10.1038/s12276-022-00921-x.Peer-Reviewed Original Research
2021
Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells
Choi W, Ryu T, Lee J, Shim Y, Kim M, Kim H, Kim Y, Yang K, Kim K, Choi S, Kim W, Kim S, Eun H, Jeong W. Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells. Hepatology 2021, 74: 2170-2185. PMID: 33932306, DOI: 10.1002/hep.31875.Peer-Reviewed Original Research
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