Yang Zhou, PhD, MPH
Associate Research ScientistCards
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Research
Publications
2026
A107-13 Myeloid Chitinase 3-like-1 Expression in Pulmonary Arterial Hypertension: A Potential Mechanism in Disease Development
Dunlop M, Norbrun C, Sorkhdini P, Yang D, Hou Y, Yang A, Singh N, Ventetuolo C, Zhou Y. A107-13 Myeloid Chitinase 3-like-1 Expression in Pulmonary Arterial Hypertension: A Potential Mechanism in Disease Development. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.5626. DOI: 10.1093/ajrccm/aamag162.5626.Peer-Reviewed Original ResearchPulmonary arterial hypertensionPeripheral blood mononuclear cellsBone marrow-derived macrophagesHuman peripheral blood mononuclear cellsArterial hypertensionAssociated with worse hemodynamicsPulmonary arterial hypertension patientsImmune responseVascular remodelingHuman monocytesFresh human peripheral blood mononuclear cellsMice exposed to hypoxiaExpression of IL13RA2Chitinase 3-like 1Immune cell compositionProinflammatory immune responseBlood mononuclear cellsExpression of CD14Glycolytic activityWild-typeInnate immune responsePAH patientsCHI3L1 levelsWT micePositive monocytesA109-14 Type 2 Innate Immunity Promotes the Development of Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
Zhou Y, Sorkhdini P, Klubock-Shukla K, Yang D, Yang A, Norbrun C, Costa S, Introne W, Gochuico B, Belenky P, Beura L. A109-14 Type 2 Innate Immunity Promotes the Development of Pulmonary Fibrosis in Hermansky-Pudlak Syndrome. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2414. DOI: 10.1093/ajrccm/aamag162.2414.Peer-Reviewed Original ResearchHermansky-Pudlak syndromeDevelopment of pulmonary fibrosisSpontaneous lung fibrosisType 2 innate immunityInnate lymphoid cellsPulmonary fibrosisLung fibrosisFibroproliferative repairILC2 activationImmune systemLymphoid cellsMouse modelSPF miceHermansky-Pudlak syndrome patientHermansky-Pudlak syndrome type 1Pale ear miceEffector T cellsType II innate lymphoid cellsDefective protein traffickingFibrotic lung diseaseHPS-1 patientsAutosomal recessive disorderMicrobial exposureGut-lung axisT cellsBispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis
Jeong H, Sadanaga T, Lee J, Kamle S, Ma B, Zhou Y, Shin S, Elias J, Lee C. Bispecific targeting of CHI3L1 and PD-1 as a therapeutic strategy for pulmonary fibrosis. JCI Insight 2026 PMID: 42048160, DOI: 10.1172/jci.insight.201609.Peer-Reviewed Original ResearchPD-L1Pulmonary fibrosisMyofibroblast transformationPD-1Macrophage activationBispecific targetingAnti-PD-1 antibodyTherapeutic strategiesPD-1/PD-L1 pathwayAnti-PD-1PD-1/PD-L1M2-like macrophage polarizationAnti-fibrotic efficacyWild-type controlsCo-culture studiesBleomycin challengeImmune cellsM2 macrophagesTransgenic miceERK pathwayMyofibroblast differentiationCHI3L1FibrosisMacrophage polarizationCo-CultureRare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor
Balfe E, Torbey A, Stepniewski T, Zhou Y, Kohlenbach L, Sency J, Inoue A, Slosky L, Selent J, Barak L, Gross J. Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor. Molecular Pharmacology 2026, 108: 100119. PMID: 41980512, DOI: 10.1016/j.molpha.2026.100119.Peer-Reviewed Original ResearchG protein-coupled receptorsIntracellular loop 2Canonical G-proteinsLoop 2Drug targetsPharmaceutical drug targetsRhodopsin-like G protein-coupled receptorsMolecular dynamics simulationsEvolutionary conservationResidue motifGenetic toolsResonance-energy transferMembrane proteinsMissense mutationsKinase activityLoop flexibilityMotifRare variantsReceptor surface expressionG-proteinGPCR regulationDynamics simulationsG protein couplingMutationsGhrelin receptor
2025
Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection
Yang A, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman M, Boyd D, Zhou Y. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection. ELife 2025, 14: rp104359. PMID: 41439508, PMCID: PMC12736948, DOI: 10.7554/elife.104359.Peer-Reviewed Original ResearchConceptsPhospholipid scramblase 1Influenza A Virus InfectionInfluenza A virusCiliated airway epithelial cellsInterferon-stimulated genesAirway epithelial cellsScramblase 1Epithelial cellsCell surfaceSingle-cell RNA sequencing dataProtein-protein interactionsA virusRNA sequencing dataVirus-host interactionsSusceptible to IAV infectionAnti-flu activityIFN-LInterferon lambda receptor 1Sequence dataAnti-influenza drugsIAV strainsPulmonary epithelial cellsTranscriptome analysisBody weight lossExpression compartmentsPhospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection
Yang A, Ramos-Rodriguez L, Sorkhdini P, Yang D, Norbrun C, Majid S, Lee S, Zhang Y, Holtzman M, Boyd D, Zhou Y. Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection. ELife 2025, 14 DOI: 10.7554/elife.104359.3.Peer-Reviewed Original ResearchPhospholipid scramblase 1Influenza A Virus InfectionInfluenza A virusCiliated airway epithelial cellsInterferon-stimulated genesAirway epithelial cellsScramblase 1Epithelial cellsCell surfaceSingle-cell RNA sequencing dataProtein-protein interactionsA virusRNA sequencing dataVirus-host interactionsSusceptible to IAV infectionAnti-flu activityIFN-LInterferon lambda receptor 1Sequence dataAnti-influenza drugsPulmonary epithelial cellsIAV strainsTranscriptome analysisBody weight lossExpression compartmentsEvolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021
Thomas A, Rhoads A, Mayer E, O’Reilly S, Harbeck N, Curigliano G, Zhou Y, Adam V, Chan N, Conway K, Ignatiadis M, Kalinsky K, DeMichele A, Romitti P. Evolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010–2021. Npj Breast Cancer 2025, 11: 127. PMID: 41233330, PMCID: PMC12615583, DOI: 10.1038/s41523-025-00835-7.Peer-Reviewed Original ResearchHR-positive breast cancerBreast cancerSurveillance, EpidemiologyLocally advanced operable breast cancerEarly-stage breast cancerRisk assessment toolAxillary lymph node dissectionHR-positive/HER2-negativeLocally advanced diseaseOperable breast cancerInvasive lobular cancerLymph node dissectionReceptor-based subtypesIncidence patternsAssessment toolDisease burdenChemotherapy useLobular cancerNode dissectionReceptor statusClinical questionsChemotherapy benefitAdvanced diseaseHR-positiveAnatomical disease burdenVirtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators
Zhou Y, Wetsel W, Olson S, Barak L. Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators. Journal Of Chemical Information And Modeling 2025, 65: 9713-9722. PMID: 40934869, PMCID: PMC12478865, DOI: 10.1021/acs.jcim.5c00972.Peer-Reviewed Original ResearchConceptsVirtual compound screeningAllosteric compoundsDopamine D1 receptorsSide effect profileCentral nervous system disordersChemical librariesTreatment of PDIntracellular loop 2Nervous system disordersD1 receptorsDopamine receptorsParkinson's diseaseD1RG protein activationPD therapySide effectsSystem disordersCompound screeningGold standardDrug screening platformDrug activityTherapeutic targetCompoundsL-DOPAAllosteric modulatorsWhen Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury
Yang A, Zhou Y. When Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 163-165. PMID: 39903843, PMCID: PMC12334875, DOI: 10.1165/rcmb.2025-0006ed.Commentaries, Editorials and LettersArrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
Guo R, Chen O, Zhou Y, Bang S, Chandra S, Li Y, Chen G, Xie R, He W, Xu J, Zhou R, Song S, Person K, Moore M, Alwin A, Spasojevic I, Jackson M, Olson S, Caron M, Slosky L, Wetsel W, Barak L, Ji R. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell 2025, 188: 4332-4349.e21. PMID: 40393456, PMCID: PMC12335375, DOI: 10.1016/j.cell.2025.04.038.Peer-Reviewed Original ResearchConceptsRodent models of postoperative painSpinal cord nociceptive neuronsModel of postoperative painRodent modelsC-fiber responsesConditioned place preferenceAction potential firingOpioid withdrawal symptomsPrimary sensory neuronsExcitatory synaptic transmissionChronic pain managementAllosteric modulatorsInflammatory painNeuropathic painNociceptive neuronsPlace preferenceOpioid analgesiaPostoperative painG protein-biased agonistsNMDA receptorsChronic painC-fibersAnalgesic effectPsychostimulant effectsWithdrawal symptoms
Clinical Trials
Current Trials
Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
IRB ID1603017333RoleSub InvestigatorPrimary Completion Date06/16/2036Recruiting Participants
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