Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study
Lv Y, Zhang Y, Li X, Gao X, Ren Y, Deng L, Xu L, Zhou J, Wu B, Wei Y, Cui X, Xu Z, Guo Y, Qiu Y, Ye L, Chen C, Wang J, Li C, Luo Y, Yin Z, Mao C, Yu Q, Lu H, Kraus V, Zeng Y, Tong S, Shi X. Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. European Heart Journal 2024, 45: 2145-2154. PMID: 38626306, PMCID: PMC11212828, DOI: 10.1093/eurheartj/ehae206.Peer-Reviewed Original ResearchChinese Longitudinal Healthy Longevity SurveyHigher body mass indexAssociation of body mass indexBody mass indexNon-CVD mortalityOldest-old peopleWaist circumferenceOldest-oldMortality riskMendelian randomizationSingle-nucleotide polymorphismsInverse relationship of BMIStudies of body mass indexRelationship of body mass indexCardiovascular diseaseOptimal body mass indexMass indexAssociated with body mass indexCardiovascular disease mortalityMendelian randomization studiesAssociated with decreased mortality riskGenetic risk scoreNon-linear MR analysisLower mortality riskJoint effect analysisSerum 25-Hydroxyvitamin D and Risk of Disability in Activities of Daily Living among the Oldest-Old: An Observational and Mendelian Randomization Study
Li X, Chen C, Zhang Y, Wang J, Cui X, Xu L, Zhou J, Deng L, Zhang M, Lv Y, Yu Q, Shi X. Serum 25-Hydroxyvitamin D and Risk of Disability in Activities of Daily Living among the Oldest-Old: An Observational and Mendelian Randomization Study. Journal Of Nutrition 2024, 154: 1004-1013. PMID: 38246357, DOI: 10.1016/j.tjnut.2024.01.016.Peer-Reviewed Original ResearchActivities of daily livingRisk of disabilityChinese oldest-oldOldest-oldMendelian randomizationDaily livingRisk of ADL disabilityActivities of daily living statusIncidence of physical disabilityBaseline ADL statusSample Mendelian randomizationMendelian randomization studiesGenetic risk scoreInverse causal relationshipPoor health conditionsFollow-up interviewsADL disabilityGenetic instrumentsMR analysisADL statusNonlinear MRSerum 25-hydroxyvitamin DBiomarkers Cohort StudyOlder adultsHealth conditions