2021
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice
Ribera J, Portolés I, Córdoba-Jover B, Rodríguez-Vita J, Casals G, González-de la Presa B, Graupera M, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernández-Checa JC, Soria G, Tudela R, Esteve-Codina A, Espadas G, Sabidó E, Jiménez W, Sessa WC, Morales-Ruiz M. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Communications Biology 2021, 4: 1192. PMID: 34654883, PMCID: PMC8519955, DOI: 10.1038/s42003-021-02722-w.Peer-Reviewed Original ResearchConceptsKey cellular processesIntracellular ATP productionCellular processesZebrafish embryosDownstream substratesATP biosynthesisProteome analysisMitochondrial membraneEndothelial cellsDHX15ATP productionRegulatory functionsDifferential expressionComplex IVascular regulatory functionEnergy metabolismVascular biologyTumor metastasisTherapeutical targetGene deficiencyPrimary tumor growthLower oxygen consumptionVascular physiologyDownregulation of VEGFCells
1997
Regulation of the NOS Gene Family
Papapetropoulos A, Sessa W. Regulation of the NOS Gene Family. 1997, 66-85. DOI: 10.1007/978-1-4615-6039-5_4.Peer-Reviewed Original ResearchMammalian cell biologyBasic cellular processesFive-electron oxidationNOS gene familyNitric oxide synthase (NOS) familyMammalian genomesSynthase familyGene familyCellular processesMolecular regulationDistinct genesCell biologyLower speciesRecent discoveryGenesNOS isoformsIsoformsRegulationNitric oxideComplex functionsGenomeRecent advancesExcellent reviewsFamilyBiology