2000
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation
Bucci M, Gratton J, Rudic R, Acevedo L, Roviezzo F, Cirino G, Sessa W. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nature Medicine 2000, 6: 1362-1367. PMID: 11100121, DOI: 10.1038/82176.Peer-Reviewed Original ResearchConceptsCaveolin-1Signal transductionSmall-molecule mimicryCaveolae assemblyInternalization sequenceCoat proteinEndothelial cellsPhysiological importanceEndothelial nitric oxide synthase (eNOS) inhibitorTransductionCholesterol transportNitric oxide synthase inhibitorChimeric peptideInhibits nitric oxide synthesisOxide synthase inhibitorNitric oxide synthesisNew therapeutic approachesNitric oxide productionSelective inhibitionDomainPeptidesCaveolinAcute inflammationCellsSystemic administration
1999
Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters
Segal S, Brett S, Sessa W. Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters. American Journal Of Physiology 1999, 277: h1167-h1177. PMID: 10484439, DOI: 10.1152/ajpheart.1999.277.3.h1167.Peer-Reviewed Original ResearchConceptsCaveolin-3Caveolin-1Skeletal muscleCaveolin isoformsCoat proteinCaveolinFunctional interactionIntact organismEnzyme isoformsNitric oxide synthase activitySmooth muscle cellsMuscle fibersOxide synthase activityVascular smooth muscleSynthase activitySkeletal muscle fibersMuscle cellsIsoformsCell systemSystemic vasculatureVena cavaFemoral arteryAbdominal aortaPeripheral vasculatureEndothelial cells