2021
Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis
Matye D, Wang H, Luo W, Sharp R, Chen C, Gu L, Jones K, Ding W, Friedman J, Li T. Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1001-1019. PMID: 33965587, PMCID: PMC8346663, DOI: 10.1016/j.jcmgh.2021.04.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile Acids and SaltsCholesterolCombined Modality TherapyDependovirusDisease Models, AnimalFibroblast Growth FactorsFructoseGene Expression ProfilingGene Expression RegulationGenetic TherapyGenetic VectorsMaleMethylaminesMiceNon-alcoholic Fatty Liver DiseaseThiazepinesTreatment OutcomeConceptsNonalcoholic steatohepatitisBile acid synthesisTherapeutic efficacyFGF19 analogueASBT inhibitorTreatment-associated adverse eventsFecal bile acid excretionASBT inhibitionDiet-induced nonalcoholic steatohepatitisHepatic bile acid synthesisWeight lossBile acid excretionGrowth factor 15Experimental nonalcoholic steatohepatitisDiet-fed miceFurther clinical studiesNew treatment strategiesIntestinal lipid absorptionAdverse eventsAdipose inflammationMetabolic improvementTreatment attenuatesLipid malabsorptionClinical findingsTreatment strategies
2014
Hu Antigen R (HuR) Is a Positive Regulator of the RNA-binding Proteins TDP-43 and FUS/TLS Implications for Amyotrophic Lateral Sclerosis*
Lu L, Zheng L, Si Y, Luo W, Dujardin G, Kwan T, Potochick N, Thompson S, Schneider D, King P. Hu Antigen R (HuR) Is a Positive Regulator of the RNA-binding Proteins TDP-43 and FUS/TLS Implications for Amyotrophic Lateral Sclerosis*. Journal Of Biological Chemistry 2014, 289: 31792-31804. PMID: 25239623, PMCID: PMC4231657, DOI: 10.1074/jbc.m114.573246.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAmyotrophic Lateral SclerosisAnimalsAstrocytesCell LineCell Line, TumorCell SurvivalCulture Media, ConditionedCystic Fibrosis Transmembrane Conductance RegulatorDNA-Binding ProteinsELAV ProteinsELAV-Like Protein 1Gene Expression RegulationHumansHypoxiaMiceMotor NeuronsPhenotypeRNARNA-Binding Protein FUSConceptsAmyotrophic lateral sclerosis