2019
Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma
Wong PF, Wei W, Gupta S, Smithy JW, Zelterman D, Kluger HM, Rimm DL. Multiplex quantitative analysis of cancer-associated fibroblasts and immunotherapy outcome in metastatic melanoma. Journal For ImmunoTherapy Of Cancer 2019, 7: 194. PMID: 31337426, PMCID: PMC6651990, DOI: 10.1186/s40425-019-0675-0.Peer-Reviewed Original ResearchConceptsProgression-free survivalBest overall responseSmooth muscle actinOverall survivalCell countQuantitative immunofluorescenceImmune markersImmunotherapy outcomesMelanoma patientsSignificant progression-free survivalAnti-PD-1 therapyAbsence of immunotherapyPretreatment tumor specimensImmune checkpoint blockadeCell death 1Cancer-associated fibroblast (CAF) populationNegative prognostic biomarkerCancer-associated fibroblastsWhole tissue sectionsOverall responseOS associationCAF parametersCheckpoint blockadeImmune dysregulationDeath-1
2018
Semi-supervised identification of cancer subgroups using survival outcomes and overlapping grouping information
Wei W, Sun Z, da Silveira W, Yu Z, Lawson A, Hardiman G, Kelemen L, Chung D. Semi-supervised identification of cancer subgroups using survival outcomes and overlapping grouping information. Statistical Methods In Medical Research 2018, 28: 2137-2149. PMID: 29336210, PMCID: PMC6922004, DOI: 10.1177/0962280217752980.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAustraliaDatabases, FactualFemaleGenomicsHumansOvarian NeoplasmsSurvival AnalysisConceptsCancer subgroupsAustralian Ovarian Cancer StudyHigh-grade serous ovarian cancerCancer patient subgroupsSerous ovarian cancerMolecular featuresOvarian Cancer StudyCancer Genome AtlasSurvival outcomesTreatment of cancerCancer patientsPatient subgroupsOvarian cancerPersonalized treatmentCancer progressionGenome AtlasCancer studiesKey molecular featuresSubgroupsCancerClear benefitTreatmentPatientsClinicians