2024
Impact of dosing schedules on performance of rotavirus vaccines in Ghana
Asare E, Al-Mamun M, Armah G, Lopman B, Pitzer V. Impact of dosing schedules on performance of rotavirus vaccines in Ghana. Science Advances 2024, 10: eadn4176. PMID: 39661683, PMCID: PMC11633732, DOI: 10.1126/sciadv.adn4176.Peer-Reviewed Original ResearchConceptsVaccine dosing schedulesDosing scheduleDoses of RV1Median percentage reductionImprove vaccine performanceRotavirus vaccine impactThird doseRotavirus vaccineRotarix vaccineVaccine impactAdditional doseVaccine effectivenessVaccine performanceVaccineRotavirusRV1Percentage reductionChildrenRotarixImpact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions
Pitzer V, Ndeketa L, Asare E, Hungerford D, Lopman B, Jere K, Cunliffe N. Impact of rotavirus vaccination in Malawi from 2012 to 2022 compared to model predictions. Npj Vaccines 2024, 9: 227. PMID: 39562592, PMCID: PMC11576906, DOI: 10.1038/s41541-024-01008-6.Peer-Reviewed Original ResearchRotavirus-associated gastroenteritisRotavirus-negative childrenRotavirus-negative controlsImpact of rotavirus vaccinationVaccination coverageRotavirus vaccine impactAcute gastroenteritis casesNational immunization programPre-vaccination dataVaccine introductionRotavirus vaccineVaccine impactAcute gastroenteritisVaccine effectivenessGastroenteritis casesLow-income settingsImmunization programsVaccine
2023
Predicting indirect effects of rotavirus vaccination programs on rotavirus mortality among children in 112 countries
Kraay A, Chaney D, Deshpande A, Pitzer V, Lopman B. Predicting indirect effects of rotavirus vaccination programs on rotavirus mortality among children in 112 countries. Npj Vaccines 2023, 8: 32. PMID: 36871093, PMCID: PMC9985632, DOI: 10.1038/s41541-023-00632-y.Peer-Reviewed Original ResearchRotavirus vaccinationVaccine coveragePost-vaccine introductionHigh vaccine coverageRotavirus vaccination programLow vaccine coverageBirth rateWHO European RegionRotavirus deathsRotavirus mortalityRotavirus vaccineMiddle-income countriesVaccine impactDiarrhea deathsVaccination programIndirect protectionVaccinationEffect estimatesMortalityWestern Pacific RegionRegression analysisDirect protectionIncome countriesDeathHigh birth rate
2022
Comparison of model predictions of typhoid conjugate vaccine public health impact and cost-effectiveness
Burrows H, Antillón M, Gauld J, Kim J, Mogasale V, Ryckman T, Andrews J, Lo N, Pitzer V. Comparison of model predictions of typhoid conjugate vaccine public health impact and cost-effectiveness. Vaccine 2022, 41: 965-975. PMID: 36586741, PMCID: PMC9880559, DOI: 10.1016/j.vaccine.2022.12.032.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioRoutine vaccinationVaccine impactPublic health impactOne-time catchPotential public health impactHigh-incidence settingsTyphoid fever casesCost-effectiveness ratioMonths of ageHealth impactsModel-predicted outcomesPrimary outcomeChronic carriersIncidence settingsSymptomatic casesVaccine introductionEndemic settingsVaccine deploymentFever casesVaccinationTyphoid casesIncremental costTyphoid transmissionMonthsPredicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis
Kraay A, Steele M, Baker J, Hall E, Deshpande A, Saidzosa B, Mukaratirwa A, Boula A, Mpabalwani E, Kiulia N, Tsolenyanu E, Enweronu-Laryea C, Abebe A, Beyene B, Tefera M, Willilo R, Batmunkh N, Pastore R, Mwenda J, Antoni S, Cohen A, Pitzer V, Lopman B. Predicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis. Vaccine 2022, 40: 6631-6639. PMID: 36210251, PMCID: PMC10351612, DOI: 10.1016/j.vaccine.2022.09.072.Peer-Reviewed Original ResearchConceptsRotavirus vaccinationRotavirus positivityVaccine introductionOne-dose scheduleTwo-dose seriesRotavirus burdenRotavirus casesRotavirus gastroenteritisHospital admissionMiddle-income countriesVaccine impactVaccinated individualsLong-term impactMortality burdenPercent reductionVaccinationLife yearsIndirect protectionLow-income countriesLong-term magnitudePositivityDeathBurdenYearsIntroduction Data