Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81 PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaWhole genome sequencing study of identical twins discordant for psychosis
Ormond C, Ryan N, Hedman A, Cannon T, Sullivan P, Gill M, Hultman C, Heron E, Johansson V, Corvin A. Whole genome sequencing study of identical twins discordant for psychosis. Translational Psychiatry 2024, 14: 313. PMID: 39080272, PMCID: PMC11289105, DOI: 10.1038/s41398-024-02982-0.Peer-Reviewed Original ResearchConceptsCopy number variantsSequencing studiesGenic copy number variantsWhole-genome sequencing studiesRare genic copy number variantsDeleterious missense variantsWhole-genome sequencingExome sequencing studiesGenome sequencing studiesMZ twinsPost-zygotic eventsPairs of MZ twinsGenome sequenceIdentical genomesDNA variantsMissense variantsOverlapped genesPsychotic phenotypesPsychotic disordersBipolar disorderRare variantsMZ twin studiesPhenotypic discordanceTwin studiesTwin pairs