2003
Positive influence of AP-2α transcription factor on cadherin gene expression and differentiation of the ocular surface
West-Mays J, Sivak J, Papagiotas S, Kim J, Nottoli T, Williams T, Fini M. Positive influence of AP-2α transcription factor on cadherin gene expression and differentiation of the ocular surface. Differentiation 2003, 71: 206-216. PMID: 12694203, PMCID: PMC2517417, DOI: 10.1046/j.1432-0436.2003.710302.x.Peer-Reviewed Original Research
1999
AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle
West-Mays J, Zhang J, Nottoli T, Hagopian-Donaldson S, Libby D, Strissel K, Williams T. AP-2αTranscription Factor Is Required for Early Morphogenesis of the Lens Vesicle. Developmental Biology 1999, 206: 46-62. PMID: 9918694, DOI: 10.1006/dbio.1998.9132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAquaporinsChimeraDNA-Binding ProteinsEyeEye ProteinsGene Expression Regulation, DevelopmentalHistocytochemistryHomeodomain ProteinsImmunohistochemistryLens, CrystallineMembrane GlycoproteinsMiceMice, KnockoutMorphogenesisPaired Box Transcription FactorsPAX6 Transcription FactorPhenotypeRepressor ProteinsTranscription Factor AP-2Transcription FactorsConceptsOcular defectsGanglion cell layerAP-2alphaRetinoic acid-responsive geneNeural retinaChimeric miceOcular tissuesOcular phenotypeDorsal retinalOptic cupCell layerLens vesicleAP-2 transcription factorsEyesEarly morphogenesisSurface ectodermLens developmentKnockout embryosCurrent studyAP-2 proteinsAcid-responsive genesExpression patternsPersistent adhesionTranscription factorsComplete lack
1998
AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
Nottoli T, Hagopian-Donaldson S, Zhang J, Perkins A, Williams T. AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13714-13719. PMID: 9811866, PMCID: PMC24885, DOI: 10.1073/pnas.95.23.13714.Peer-Reviewed Original ResearchConceptsAP-2Neural tubePleiotropic developmental abnormalitiesAP-2 geneCritical new roleLimb pattern formationRange of phenotypesBody wallLethal phenotypeKnockout miceMorphogenic pathwaysChimeric miceEye formationDevelopmental mechanismsHomozygous disruptionLimb duplicationsTeratogenic levelsDefective developmentDevelopmental abnormalitiesRetinoic acidPhenotypeMechanism of actionIndependent requirementsPattern formationChimeras