Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study
Murphy N, Pham G, Weyland A, Engelhardt J, Kypriotakis G, Thomas Y, Kosten T, Moukaddam N, Mathew S, Swann A. Lithium reduces impulsive decision making in transdiagnostic patients at high risk for suicide attempt recurrence: A randomized, double blind, placebo-controlled, crossover study. Journal Of Affective Disorders Reports 2024, 17: 100833. DOI: 10.1016/j.jadr.2024.100833.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleTime perception tasksSuicidal behaviorImpulsive decisionsSuicide attemptsResponse latencySpectrum of suicidal behaviorsLethal suicidal behaviorMeasures of impulsivityLithium doseConservative response biasSevere suicide attemptsDouble-blind crossover designRandomized double-blind crossover designPrevent suicide riskEffects of lithiumPill placeboMemory taskBehavioral therapySuicide riskResponse biasAdjunctive behavioral therapySelf-harmAssociated with attemptsPrediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models
Miranda O, Fan P, Qi X, Wang H, Brannock M, Kosten T, Ryan N, Kirisci L, Wang L. Prediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models. Drug And Alcohol Dependence 2024, 255: 111066. PMID: 38217979, PMCID: PMC10853953, DOI: 10.1016/j.drugalcdep.2023.111066.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol use disorderComorbid post-traumatic stress disorderStress disorderUse disorderCognitive behavioral therapyElectronic medical recordsBehavioral therapyMental disordersNeighborhood-level social determinants of healthNeighborhood-level social determinantsSocial determinants of healthArea under the receiver operating curveDeterminants of healthVeteran dataMedical recordsDisordersPsychotherapyPrediction of adverse eventsVeteran statusPatient's increased riskHigh-risk populationAnalyzed electronic medical recordsUniversity of Pittsburgh Medical CenterAdverse events