2021
Novel homozygous variant in BMP1 associated with a rare osteogenesis imperfecta phenotype
Choksi I, Cox A, Robinson C, Bale A, Carpenter T. Novel homozygous variant in BMP1 associated with a rare osteogenesis imperfecta phenotype. Osteoporosis International 2021, 32: 1239-1244. PMID: 33624138, DOI: 10.1007/s00198-021-05838-1.Peer-Reviewed Original ResearchConceptsVertebral compression fracturesNovel homozygous variantOsteogenesis imperfectaMultiple vertebral compression fracturesZ-scoreHomozygous variantBilateral tibial fracturesLumbar spine BMDTotal hip BMDEffectiveness of bisphosphonatesFemoral neck BMDHeight z-scoreHomozygous missense variantBroad phenotypic spectrumBisphosphonate therapyBP therapySpinal osteopeniaSymptomatic reliefClinical presentationRecurrent fracturesSpine BMDTibial fracturesCompression fracturesHip BMDNeck BMD
2019
Severity of reduced bone mineral density and risk of fractures in long‐term survivors of childhood leukemia and lymphoma undergoing guideline‐recommended surveillance for bone health
Bloomhardt HM, Sint K, Ross WL, Rotatori J, Ness K, Robinson C, Carpenter TO, Chow EJ, Kadan‐Lottick N. Severity of reduced bone mineral density and risk of fractures in long‐term survivors of childhood leukemia and lymphoma undergoing guideline‐recommended surveillance for bone health. Cancer 2019, 126: 202-210. PMID: 31536650, DOI: 10.1002/cncr.32512.Peer-Reviewed Original ResearchConceptsLow bone mineral densityReduced bone mineral densityBone mineral densityLymphoma survivorsMineral densityLumbar spine BMD Z-scoreChildhood leukemia/lymphomaPatient/treatment factorsSpine BMD Z-scoreDual-energy X-ray absorptiometryGuideline-recommended surveillanceBMD Z-scoresLong-term survivorsRisk of fractureCross-sectional studyLeukemia/lymphomaLong bone fracturesX-ray absorptiometrySurvivorship clinicBone healthMultivariable analysisMean ageChronic conditionsMedical recordsWhite race
2016
Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade
Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C. Pigment epithelium‐derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. The FASEB Journal 2016, 30: 2837-2848. PMID: 27127101, PMCID: PMC4970601, DOI: 10.1096/fj.201500027r.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorOsteogenesis imperfecta type VIWnt/β-catenin signalingBone massOI type VIΒ-catenin signalingAbility of PEDFTrabecular bone volume/total volumeType VIBone volume/total volumeWild-type miceEpithelium-derived factorBone plasticityPEDF-knockout miceMesenchymal stem cell commitmentBone volume fractionKO micePEDF peptidesStem cell commitmentFluorescent protein reporterCombination of Wnt3aMouse modelWnt modulatorsBone mineralizationMice
2014
Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY
Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surgery For Obesity And Related Diseases 2014, 10: 878-884. PMID: 24969093, PMCID: PMC4113565, DOI: 10.1016/j.soard.2014.01.021.Peer-Reviewed Original ResearchConceptsBone turnover markersDiet-induced obeseWeeks of ageSham surgeryBone lossPeptide YYRYGB animalsBone volumeHigher serum parathyroid hormoneLower trabecular bone volumeMale Sprague-Dawley ratsBone mass differencesElevated peptide YYHigher serum CTXVitamin D malabsorptionSerum parathyroid hormoneGastric bypass surgeryLow serum bicarbonateVitamin D deficiencyNormal calcium dietCortical bone volumeSham control ratsTrabecular bone volumeSprague-Dawley ratsMetabolic bone disease
2013
Determination of mesenchymal stem cell fate by pigment epithelium‐derived factor (PEDF) results in increased adiposity and reduced bone mineral content
Gattu AK, Swenson ES, Iwakiri Y, Samuel VT, Troiano N, Berry R, Church CD, Rodeheffer MS, Carpenter TO, Chung C. Determination of mesenchymal stem cell fate by pigment epithelium‐derived factor (PEDF) results in increased adiposity and reduced bone mineral content. The FASEB Journal 2013, 27: 4384-4394. PMID: 23887690, PMCID: PMC3804749, DOI: 10.1096/fj.13-232900.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorMesenchymal stem cell fateHuman MSCsMesenchymal stem cell differentiationStem cell fateStem cell differentiationEpithelium-derived factorCell fateOsteogenesis imperfecta type VISignal transductionMSC differentiationNegative regulatorSERPINF1 geneProtein productsOsteoblast differentiationCell differentiationOsteoblast precursorsHuman diseasesPEDF-knockout micePeroxisome proliferator-activated receptorDifferentiation patternsMurine MSCsProliferator-activated receptorAdipocyte markersControl-treated cells
2012
Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants
Abrams SA, Hawthorne KM, Rogers SP, Hicks PD, Carpenter TO. Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants. BMC Pediatrics 2012, 12: 6. PMID: 22248486, PMCID: PMC3271033, DOI: 10.1186/1471-2431-12-6.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBone DensityFetal BloodHispanic or LatinoHumansInfantInfant, NewbornTexasVitamin DVitaminsWhite PeopleConceptsBone mineral contentBone mineral densityVitamin D supplementationD supplementationVitamin DHispanic infantsDaily vitamin D intakeCaucasian infantsIU/dayVitamin D intakeVitamin D3 supplementationVitamin D statusMonths of lifeNon-Hispanic CaucasiansD intakeD statusD3 supplementationSupplementation interventionsBone healthCord serumMineral densityInfantsFirst monthFirst weekBone mineralization
2010
Rapid Correction of Bone Mass after Parathyroidectomy in an Adolescent with Primary Hyperparathyroidism
Vanstone MB, Udelsman RD, Cheng DW, Carpenter TO. Rapid Correction of Bone Mass after Parathyroidectomy in an Adolescent with Primary Hyperparathyroidism. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: e347-e350. PMID: 21106715, DOI: 10.1210/jc.2010-1723.Peer-Reviewed Original ResearchMeSH Keywords25-Hydroxyvitamin D 2Absorptiometry, PhotonAdenomaAdolescentBone and BonesBone DensityHumansHydronephrosisHyperparathyroidism, PrimaryKidneyKidney CalculiLithotripsyMalePainParathyroid NeoplasmsParathyroidectomyRadionuclide ImagingRadiopharmaceuticalsSpineTechnetium Tc 99m SestamibiTrabecular MeshworkUltrasonographyConceptsBone mineral densityPrimary hyperparathyroidismMineral densityElevated parathyroid hormone levelsLarge tertiary care centerDual-energy X-ray absorptiometryBiochemical evaluationEnergy X-ray absorptiometryDual-phase technetiumRight foot painParathyroid hormone levelsTertiary care centerDiagnosis of hyperparathyroidismTime of diagnosisMain outcome measurementsX-ray absorptiometryBone mineral contentFlank painFoot painGross hematuriaRenal ultrasonographyVague symptomatologyMale presentingThyroid bedOsteoporotic fractures
2008
Dual Energy X-ray Absorptiometry Interpretation and Reporting in Children and Adolescents: The 2007 ISCD Pediatric Official Positions
Gordon CM, Bachrach LK, Carpenter TO, Crabtree N, Fuleihan G, Kutilek S, Lorenc RS, Tosi LL, Ward KA, Ward LM, Kalkwarf HJ. Dual Energy X-ray Absorptiometry Interpretation and Reporting in Children and Adolescents: The 2007 ISCD Pediatric Official Positions. Journal Of Clinical Densitometry 2008, 11: 43-58. PMID: 18442752, DOI: 10.1016/j.jocd.2007.12.005.Peer-Reviewed Original Research
2007
Evaluation of bone and mineral disorders.
Ardeshirpour L, Cole DE, Carpenter TO. Evaluation of bone and mineral disorders. Pediatric Endocrinology Reviews : PER 2007, 5 Suppl 1: 584-98. PMID: 18167468.Peer-Reviewed Original ResearchConceptsParathyroid hormoneVitamin D homeostasisVitamin D metabolitesEvaluation of boneD homeostasisD metabolitesMineral disordersDiagnostic modalitiesHormonal imbalanceMetabolic diseasesDiagnostic acumenGenetic testingHereditary disorderSkeletal systemHormoneDisordersDiagnostic capabilitiesBoneConcise reviewCalciumWidespread useDiseaseImpairment
2006
A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls
Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D, Cohen D. A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4866-4872. PMID: 17018656, PMCID: PMC2995550, DOI: 10.1210/jc.2006-1391.Peer-Reviewed Original ResearchConceptsBone mineral contentHip bone mineral contentDietary Mg intakeMg supplementationBone massMg intakeSpinal bone mineral contentMid-late pubertyOld Caucasian girlDouble-blind trialClinical Research CenterPrimary outcome measureBone mineral densityCommunity pediatricians' officesSerum mineral levelsMagnesium oxide supplementationPill countDietary diariesTotal hipFemoral neckInterventional studyMineral densityHealthy girlsBone markersOutcome measures
2005
Relationships among Vitamin D Levels, Parathyroid Hormone, and Calcium Absorption in Young Adolescents
Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO. Relationships among Vitamin D Levels, Parathyroid Hormone, and Calcium Absorption in Young Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 5576-5581. PMID: 16076940, PMCID: PMC1283091, DOI: 10.1210/jc.2005-1021.Peer-Reviewed Original ResearchConceptsVitamin D statusCalcium absorptionD statusDihydroxyvitamin DVitamin D insufficiencyVitamin D levelsBone mineral densityCalcium absorption fractionYr of ageEffects of prebioticsD insufficiencySerum PTHPTH secretionD calciumParathyroid hormoneD levelsPediatric dataMineral densityMidpubertal boysYoung adolescentsPTHBone formationWhole bodyHigh rateAdolescents
2004
Multisystem study of 20 older adults with Williams syndrome
Cherniske EM, Carpenter TO, Klaiman C, Young E, Bregman J, Insogna K, Schultz RT, Pober BR. Multisystem study of 20 older adults with Williams syndrome. American Journal Of Medical Genetics Part A 2004, 131A: 255-264. PMID: 15534874, DOI: 10.1002/ajmg.a.30400.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone DensityFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWilliams SyndromeConceptsStandard oral glucose tolerance testingOral glucose tolerance testingNatural historyLong-term natural historyHigh-frequency sensorineural hearing lossFrequency sensorineural hearing lossOlder adultsAbnormal body habitusWilliams syndromeAbnormal glucose toleranceGlucose tolerance testingBone mineral densitySensorineural hearing lossMultiple organ systemsBrain MRI scansYears of ageDiverticular diseaseGastrointestinal symptomsSubclinical hypothyroidismGlucose toleranceMultimodal therapyDEXA scanningBody habitusMineral densityCardiovascular disease