2010
Rapid Correction of Bone Mass after Parathyroidectomy in an Adolescent with Primary Hyperparathyroidism
Vanstone MB, Udelsman RD, Cheng DW, Carpenter TO. Rapid Correction of Bone Mass after Parathyroidectomy in an Adolescent with Primary Hyperparathyroidism. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: e347-e350. PMID: 21106715, DOI: 10.1210/jc.2010-1723.Peer-Reviewed Original ResearchMeSH Keywords25-Hydroxyvitamin D 2Absorptiometry, PhotonAdenomaAdolescentBone and BonesBone DensityHumansHydronephrosisHyperparathyroidism, PrimaryKidneyKidney CalculiLithotripsyMalePainParathyroid NeoplasmsParathyroidectomyRadionuclide ImagingRadiopharmaceuticalsSpineTechnetium Tc 99m SestamibiTrabecular MeshworkUltrasonographyConceptsBone mineral densityPrimary hyperparathyroidismMineral densityElevated parathyroid hormone levelsLarge tertiary care centerDual-energy X-ray absorptiometryBiochemical evaluationEnergy X-ray absorptiometryDual-phase technetiumRight foot painParathyroid hormone levelsTertiary care centerDiagnosis of hyperparathyroidismTime of diagnosisMain outcome measurementsX-ray absorptiometryBone mineral contentFlank painFoot painGross hematuriaRenal ultrasonographyVague symptomatologyMale presentingThyroid bedOsteoporotic fractures
2005
Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes
Sabbagh Y, Carpenter TO, Demay MB. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 9637-9642. PMID: 15976027, PMCID: PMC1172249, DOI: 10.1073/pnas.0502249102.Peer-Reviewed Original ResearchConceptsParathyroid hormone levelsMineral ion homeostasisRachitic changesHormone levelsAbnormal mineral ion homeostasisDihydroxyvitamin D levelsVitamin D deficiencyDegree of hypophosphatemiaHypertrophic chondrocyte layerVitamin D receptorHypertrophic chondrocytesNormal phosphorus levelsGrowth plate maturationD deficiencyD levelsNormal calciumD receptorChondrocyte layerHypophosphatemiaVDR actionChondrocyte apoptosisNull miceRicketsCaspase-mediated apoptosisHypercalcemia