2024
Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence
Keding T, Russell J, Zhu X, He Q, Li J, Herringa R. Diverging Effects of Violence Exposure and Psychiatric Symptoms on Amygdala-Prefrontal Maturation during Childhood and Adolescence. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39182725, DOI: 10.1016/j.bpsc.2024.08.003.Peer-Reviewed Original ResearchBasolateral amygdalaFunctional connectivityPsychiatric symptomsViolence exposureCircuit maturationOrbitofrontal cortex functional connectivityDevelopment of psychiatric symptomsResting-state functional connectivityEffects of violence exposureAmygdala-prefrontal cortexSeverity of psychopathologyBrain age gap estimationIncreased psychiatric symptomsPhiladelphia Neurodevelopmental CohortThreat appraisal processEffects of adversityExposure to violenceNeurobiological correlatesAssociated with delayed maturationBrain circuitryNeurodevelopmental mechanismsPsychiatric riskIndividual differencesNeurodevelopmental CohortAtypical neurodevelopmentFamilial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2021
Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder
George G, Keding T, Heyn S, Herringa R. Longitudinal hippocampal circuit change differentiates persistence and remission of pediatric posttraumatic stress disorder. Depression And Anxiety 2021, 39: 8-18. PMID: 34843625, PMCID: PMC8763137, DOI: 10.1002/da.23229.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderFunctional magnetic resonance imagingPosttraumatic stress disorderTD youthHippocampal activationStress disorderFunctional connectivityEmotional processing taskFunctional brain substratesHippocampal functional connectivityFunctional connectivity analysisFunctional brain abnormalitiesPTSD youthEmotion processingThreat stimuliNeutral imagesPediatric PTSDBrain substratesPTSD groupActivation findingsConnectivity analysisProcessing tasksVisual cortexLongitudinal studyYouthNeurobehavioral correlates of impaired emotion recognition in pediatric PTSD
Heyn SA, Schmit C, Keding TJ, Wolf R, Herringa RJ. Neurobehavioral correlates of impaired emotion recognition in pediatric PTSD. Development And Psychopathology 2021, 34: 946-956. PMID: 33487187, PMCID: PMC9717496, DOI: 10.1017/s0954579420001704.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPediatric posttraumatic stress disorderTD youthFunctional connectivityImplicit emotion processing taskEmotion recognition taskImpaired emotion recognitionFunctional magnetic resonance imagingEmotion processing taskSample of youthNeutral facesAngry expressionsVisual attentionFMRI taskEmotion recognitionNeurobehavioral correlatesStress disorderNeurological substrateRecognition taskProcessing tasksYouth experienceMultimethod approachYouthImpaired abilityThreat recognition
2018
T57. Abnormal Development of Amygdala Functional Connectivity During Emotion Processing in Pediatric Post-Traumatic Stress Disorder
Keding T, Motzkin J, Herringa R. T57. Abnormal Development of Amygdala Functional Connectivity During Emotion Processing in Pediatric Post-Traumatic Stress Disorder. Biological Psychiatry 2018, 83: s150-s151. DOI: 10.1016/j.biopsych.2018.02.393.Peer-Reviewed Original Research