2024
Gene Copy Number Alterations Identify Subsets of Mycosis Fungoides/Sézary Syndrome Patients with Worse Survival Outcomes
Kiwan A, Kewan T, Xu M, Siddon A, Girardi M, Sethi T, Foss F. Gene Copy Number Alterations Identify Subsets of Mycosis Fungoides/Sézary Syndrome Patients with Worse Survival Outcomes. Blood 2024, 144: 4440-4440. DOI: 10.1182/blood-2024-205144.Peer-Reviewed Original ResearchGene copy number alterationsAssociated with poor OSAbsolute lymphocyte countFluorescence in situ hybridization panelAssociated with worse OSCirculating tumor cellsFluorescence in situ hybridizationOverall survivalCopy number alterationsT cell receptorPoor OSSurvival outcomesTumor cellsMedian OSCox proportional hazardsBlood involvementATM deletionArid1a deletionT cellsElevated absolute lymphocyte countMedian absolute lymphocyte countAssociated with better OSMedian age of patientsMultivariate CPH modelZEB1 deletion
2015
Interim Absolute Lymphocyte Count (ALC) As a Predictor of Survival in Hodgkin Lymphoma
Sethi T, Nguyen V, Morgan D, Greer J, Reddy N. Interim Absolute Lymphocyte Count (ALC) As a Predictor of Survival in Hodgkin Lymphoma. Blood 2015, 126: 2640. DOI: 10.1182/blood.v126.23.2640.2640.Peer-Reviewed Original ResearchProgression-free survivalAbsolute lymphocyte countClassical Hodgkin lymphomaNodular sclerosis Hodgkin lymphomaSuperior progression-free survivalOverall survivalHodgkin's lymphomaLymphocyte countAdvanced-stage Hodgkin lymphomaMixed cellularity Hodgkin's lymphomaCompletion of chemotherapyInitial chemotherapy treatmentMedian overall survivalAdvanced stage diseaseCompletion of therapyFirst-line chemotherapyStage Hodgkin lymphomaKaplan-Meier methodPredictors of survivalImmune effector cellsLog-rank testTime of apheresisNew therapeutic agentsTerms of histologyALC recovery