2023
Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia
Sasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.Peer-Reviewed Case Reports and Technical NotesThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original Research
2022
Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography
Ahn S, Ta K, Thorn S, Onofrey J, Melvinsdottir I, Lee S, Langdon J, Sinusas A, Duncan J. Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography. Medical Image Analysis 2022, 84: 102711. PMID: 36525845, PMCID: PMC9812938, DOI: 10.1016/j.media.2022.102711.Peer-Reviewed Original ResearchConceptsSpatial transformer networkMotion trackingNoisy displacement fieldReliable motion estimationMotion tracking methodCardiac strain analysisTransformer networkDisplacement fieldDisplacement pathsMotion fieldTracking methodMotion estimationExperimental resultsStrain analysisSuperior performanceTemporal constraintsCardiac motionTrackingRegularization functionDependent featuresEchocardiography imagesNetworkPrior assumptionsFieldQuantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study
Yousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.Peer-Reviewed Original ResearchIncreasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction
Xie H, Thorn S, Chen X, Zhou B, Liu H, Liu Z, Lee S, Wang G, Liu YH, Sinusas AJ, Liu C. Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction. Journal Of Nuclear Cardiology 2022, 30: 86-100. PMID: 35508796, DOI: 10.1007/s12350-022-02972-z.Peer-Reviewed Original ResearchConceptsDeep learningReconstruction qualityImage reconstructionDeep learning methodsDeep neural networksDeep learning resultsImage qualityNetwork trainingSPECT image reconstructionNeural networkLearning methodsHigh image resolutionImage volumesClinical softwareImage metricsImage resolutionReconstruction resultsImproved image qualityTesting dataLearning resultsNetwork resultsPhysical phantomStationary imagingDifferent subjectsLearning
2021
Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.
Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.Peer-Reviewed Original ResearchConceptsReduced Myocardial Flow ReserveMyocardial flow reserveRaynaud's phenomenonPrimary Raynaud's phenomenonSecondary Raynaud's phenomenonPatient controlsHealthy participantsFlow reservePositron Emission Tomography/Computed TomographyEmission Tomography/Computed TomographyTomography/Computed TomographyPositron emission tomography/Impaired Myocardial Flow ReserveCoronary microvascular dysfunctionLarge prospective studiesMultivariable logistic regressionEmission tomography/PET/CTSSc-RPMicrovascular dysfunctionClinical predictorsIndependent predictorsSystemic sclerosisPrognostic valueProspective study
2020
Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients
Liu H, Thorn S, Wu J, Fazzone-Chettiar R, Sandoval V, Miller EJ, Sinusas AJ, Liu YH. Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients. Journal Of Nuclear Cardiology 2020, 28: 1236-1248. PMID: 32715416, DOI: 10.1007/s12350-020-02278-y.Peer-Reviewed Original Research
2019
A robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomography
Liu H, Wu J, Sun J, Wu T, Fazzone‐Chettiar R, Thorn S, Sinusas AJ, Liu Y. A robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomography. Medical Physics 2019, 46: 5002-5013. PMID: 31444909, DOI: 10.1002/mp.13783.Peer-Reviewed Original Research
2018
Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT
Wu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn S, Zonouz TH, Liu YH, Lampert R, Sinusas AJ, Carson RE, Liu C. Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT. Journal Of Nuclear Medicine 2018, 59: 1574-1580. PMID: 29476001, DOI: 10.2967/jnumed.117.202143.Peer-Reviewed Original Research
2016
T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1
Hu C, Sinusas AJ, Huber S, Thorn S, Stacy MR, Mojibian H, Peters DC. T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1. Journal Of Cardiovascular Magnetic Resonance 2016, 19: 63. PMID: 28821300, PMCID: PMC5563030, DOI: 10.1186/s12968-017-0375-1.Peer-Reviewed Original ResearchAlgorithmsAnimalsCardiomyopathiesComputer SimulationContrast MediaFeasibility StudiesFemaleFibrosisHeart AtriaHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedModels, CardiovascularMonte Carlo MethodOrganometallic CompoundsPhantoms, ImagingPredictive Value of TestsReproducibility of ResultsSus scrofaQuantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method
Wu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine 2016, 57: 1226-1232. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.Peer-Reviewed Original Research3-IodobenzylguanidineAdultAgedAlgorithmsArtifactsComputer SimulationFemaleHeartHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularModels, StatisticalMyocardiumRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityTissue DistributionTomography, Emission-Computed, Single-PhotonEditorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue?
Thorn SL, Sinusas AJ. Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue? Journal Of Nuclear Cardiology 2016, 24: 1085-1088. PMID: 26976143, DOI: 10.1007/s12350-016-0458-7.Peer-Reviewed Original Research
2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseVascular calcificationArterial calcificationOrphan diseaseCommon diseaseSequelae of diseaseEctopic vascular calcificationInternal elastic laminaPrevent mortalityRenal failureCardiac failureKidney diseaseSubcutaneous administrationRodent modelsAnimal modelsEctopic calcificationVascular wallLarge arteriesElastic laminaDiseaseCalcificationCalciphylaxisDecreased concentrationSclerosisArteryScatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators
Fan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-6911. PMID: 26632046, DOI: 10.1118/1.4934830.Peer-Reviewed Original ResearchConceptsDual-radionuclide imagingCrosstalk correction methodTEW methodLine source experimentDefect contrastSource experimentsMonte Carlo simulationsIncomplete charge collectionCadmium zinc telluride detectorsLow-energy tailImaging systemCarlo simulationsPinhole collimatorCardiac SPECT systemEnergy tailDetector effectsEnergy spectrumPoint source measurementsSPECT systemCZT detectorsTriple energy window (TEW) methodScatter modelDedicated cardiac SPECT systemsCorrection methodCrosstalk correction
2014
The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
Ahmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-4758. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.Peer-Reviewed Original ResearchConceptsMatrix therapyMouse myocardial infarction modelMyocardial infarction modelCardiac cell therapySynergistic therapeutic effectTherapeutic effectMyocardial perfusionParacrine propertiesInfarcted myocardiumAngiogenic cellsInfarction modelOverall efficacyTherapyCell therapyAngiogenic potentialCACSΑ5 integrinIntegrin α2EngraftmentIntegrin α5PerfusionCellsIntegrinsCollagen matrixCAC function
2012
18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography
Zhang Y, Dasilva JN, Hadizad T, Thorn S, Kuraitis D, Renaud JM, Ahmadi A, Kordos M, Dekemp RA, Beanlands RS, Suuronen EJ, Ruel M. 18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography. Cell Transplantation 2012, 21: 1821-1835. PMID: 22469629, DOI: 10.3727/096368911x637416.Peer-Reviewed Original ResearchConceptsCirculating Progenitor CellsPositron emission tomographyEmission tomographyCell therapyPET imagingCell transplantation groupProgenitor cellsCoronary artery ligationRat myocardial infarction modelInfarct border zoneHeart tissue sectionsMyocardial infarction modelBorder zoneCardiac cell therapyTransplantation groupIschemic/Artery ligationH posttransplantationBest modalityHuman progenitor cellsIntramyocardial injectionH postinjectionInjection siteTissue biodistributionInfarction model
2010
Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program
Klein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. Journal Of Nuclear Cardiology 2010, 17: 600-616. PMID: 20387135, DOI: 10.1007/s12350-010-9225-3.Peer-Reviewed Original Research
2009
In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome
Ha AC, Renaud JM, deKemp RA, Thorn S, DaSilva J, Garrard L, Yoshinaga K, Abraham A, Green MS, Beanlands RS, Gollob MH. In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome. Circulation Cardiovascular Imaging 2009, 2: 485-491. PMID: 19920047, DOI: 10.1161/circimaging.109.853291.Peer-Reviewed Original ResearchMeSH KeywordsAdultAMP-Activated Protein KinasesCase-Control StudiesEchocardiographyFemaleFluorodeoxyglucose F18Heart DiseasesHumansMaleMetabolic DiseasesMiddle AgedMutationMyocardiumPhenotypeRadiographic Image Interpretation, Computer-AssistedRubidium RadioisotopesStatistics, NonparametricSyndromeTomography, Emission-ComputedConceptsMyocardial glucose uptakeSignificant myocardial scarFDG-PET imagingPRKAG2 cardiac syndromeCardiac syndromeGlucose uptakeAdult patientsMyocardial scarMetabolic diseasesControl groupMedian blood glucoseEuglycemic hyperinsulinemic clampStable blood glucose levelsBlood glucose levelsInherited metabolic diseaseMin/Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyMyocardial glucose transportPerfusion scanBlood glucoseControl subjectsHyperinsulinemic clampAffected patientsDistinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen
Folmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR. Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen. Circulation Genomic And Precision Medicine 2009, 2: 457-466. PMID: 20031621, DOI: 10.1161/circgenetics.108.834564.Peer-Reviewed Original ResearchConceptsTransgenic miceR302Q mutationGlycogen contentAcute expressionCardiomyocyte-restricted expressionAMPK activationTransgenic adult miceNeonatal rat cardiomyocytesChronic modelWolff-ParkinsonGlycogen synthase activityWhite syndromeCardiac hypertrophyAdult miceGlycogen storage cardiomyopathyMyocardial glycogenDirect effectCompensatory alterationsRat cardiomyocytesFamilial formsMiceEarly signaling eventCardiomyopathyAMPK activityHeart
2008
Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells
Zhang Y, Thorn S, DaSilva JN, Lamoureux M, deKemp RA, Beanlands RS, Ruel M, Suuronen EJ. Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells. Circulation Cardiovascular Imaging 2008, 1: 197-204. PMID: 19808543, DOI: 10.1161/circimaging.108.781120.Peer-Reviewed Original ResearchConceptsPositron emission tomographyIschemic hind limbIschemic hind limb musclesCirculating Progenitor CellsHind limbProgenitor cellsRats 2 weeksFemoral artery ligationNonspecific tissueHind limb musclesMechanism of actionEarly posttransplantationCollagen matrixSmall animal positron emission tomographyArtery ligationMinutes postinjectionProgenitor cell retentionAnimal positron emission tomographyLimb musclesCell therapyHuman CPCsTarget tissuesPosttransplantationTomographyFDG