2008
Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells
Zhang Y, Thorn S, DaSilva JN, Lamoureux M, deKemp RA, Beanlands RS, Ruel M, Suuronen EJ. Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells. Circulation Cardiovascular Imaging 2008, 1: 197-204. PMID: 19808543, DOI: 10.1161/circimaging.108.781120.Peer-Reviewed Original ResearchConceptsPositron emission tomographyIschemic hind limbIschemic hind limb musclesCirculating Progenitor CellsHind limbProgenitor cellsRats 2 weeksFemoral artery ligationNonspecific tissueHind limb musclesMechanism of actionEarly posttransplantationCollagen matrixSmall animal positron emission tomographyArtery ligationMinutes postinjectionProgenitor cell retentionAnimal positron emission tomographyLimb musclesCell therapyHuman CPCsTarget tissuesPosttransplantationTomographyFDG
2005
Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders.
Yoshinaga K, Chow BJ, dekemp RA, Thorn S, Ruddy TD, Davies RA, DaSilva JN, Beanlands R. Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders. Current Pharmaceutical Design 2005, 11: 903-32. PMID: 15777243, DOI: 10.2174/1381612053381800.Peer-Reviewed Original ResearchConceptsVivo pharmacokinetic studyDrug deliveryMolecular probesCardiovascular diseaseEffect of therapyAccuracy of PETPET/CTNon-invasive imaging modalityEvaluation of drugsMolecular imagingPositron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyPotential of PETNon-invasive modalityMechanism of actionPharmacokinetic studyCardiac molecular imagingEarly drug developmentAdvantages of PETDrug therapyDisease progressionSerial evaluationDrug treatmentReceptor levels