2023
CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder
Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.Peer-Reviewed Original ResearchOpioid use disorderOrbital frontal cortexDNA methylationKEGG enrichment analysisUse disordersMCPH lociTreatment of OUDGene OntologyEnrichment analysisOpioid-related drugsCpG sitesDrug targetsOxidative bisulfite sequencingImportant biological pathwaysDrug interaction analysisDrug-gene interaction databaseNervous system developmentSmoking statusBrain BankCortical neuronsFrontal cortexNeuronal nucleiHuman studiesGene regulationMethylome analysis
2019
Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
Maldonado MBC, de Rezende Neto NB, Nagamatsu ST, Carazzolle MF, Hoff JL, Whitacre LK, Schnabel RD, Behura SK, McKay SD, Taylor JF, Lopes FL. Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation. PLOS ONE 2019, 14: e0222329. PMID: 31513639, PMCID: PMC6742455, DOI: 10.1371/journal.pone.0222329.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsCpG islandsDNA methylationReference genome sequence assemblyDatabase of SNPsCpG sitesBull Genomes ProjectGenome sequence assemblyDivergent feed efficiencyBovine phenotypesEpigenetic polymorphismEpigenetic controlEpigenetic regulationIntergenic regionNearby genesMethylation targetsGenomic sequencesMethylation patternsSequence assemblyGenome ProjectMethylation profilesMethylation sitesSNP databaseDifferential expressionVariant annotation