2024
Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease
Kumari S, Rana B, Kumaran S, Chaudhary S, Jain S, Srivastava A, Rajan R. Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease. Neuroscience 2024, 551: 217-228. PMID: 38843989, DOI: 10.1016/j.neuroscience.2024.05.029.Peer-Reviewed Original ResearchVolume-based morphometryGray matter volumeMachine learningMagnetic resonance imagingClassification accuracyGray matter atrophySham controlsSupport vector machine (SVM)-based algorithmContralateral rotational behaviorUnilateral 6-hydroxydopamineIncrease classification accuracyAssociated with progressionMatter volumeModel of Parkinson's diseaseParkinson's diseaseBrain regionsBasal ganglia-thalamocortical circuitsPD modelSubcortical brain regionsGMV changesGray matter volume atrophyBrain morphometric changesInternal capsuleStudy of alterationsSubstantia nigra
2019
Saccadic Eye Movements in Young-Onset Parkinson’s Disease - A BOLD fMRI Study
Srivastava A, Sharma R, Goyal V, Chaudhary S, Sood S, Kumaran S. Saccadic Eye Movements in Young-Onset Parkinson’s Disease - A BOLD fMRI Study. Neuro-Ophthalmology 2019, 44: 89-99. PMID: 32395155, PMCID: PMC7202441, DOI: 10.1080/01658107.2019.1652656.Peer-Reviewed Original ResearchYoung-onset Parkinson's diseaseSaccadic eye movementsFunctional magnetic resonance imagingEye movementsParkinson's diseaseLevel-dependent (BOLD) fMRISaccadic tasksFunctional imagingFrontal gyrusGroup of patientsStatistical parametric mapping softwareMedial frontal gyrusMagnetic resonance imagingOnset Parkinson's diseaseBOLD fMRI studiesParietal cortical activityMiddle frontal gyrusSaccadic circuitryControl subjectsCingulate gyrusCortical areasReflexive saccadesPatientsAbnormal activationControl group