2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresIn vitro and in vivo NMR based metabolomics in Parkinson's disease
Chaudhary S, Kumari S, Kumaran S, Goyal V, Jain S, Kaloiya G. In vitro and in vivo NMR based metabolomics in Parkinson's disease. Journal Of Magnetic Resonance Open 2022, 10: 100050. DOI: 10.1016/j.jmro.2022.100050.Peer-Reviewed Original ResearchNon-motor symptomsParkinson's diseaseMetabolic alterationsCognitive impairmentCommon non-motor symptomCerebral metabolic alterationsPathophysiological progressionPD subgroupsEarly diagnosisEarly changesDisease pathophysiologyBrain metabolitesSpecific biomarkersNeurodegenerative diseasesDiseaseMagnetic resonance spectroscopy techniquesSymptomsImpairmentAlterationsNon-invasive characterizationPathophysiologyDementiaDiagnosisProgressionBiomarkersCerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2020
Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment
Chaudhary S, Kumaran S, Goyal V, Kalaivani M, Kaloiya G, Sagar R, Mehta N, Srivastava A, Jagannathan N. Frontal lobe metabolic alterations characterizing Parkinson’s disease cognitive impairment. Neurological Sciences 2020, 42: 1053-1064. PMID: 32729012, DOI: 10.1007/s10072-020-04626-9.Peer-Reviewed Original ResearchConceptsFrontal gray matterParkinson's disease cognitive impairmentN-acetyl aspartateHealthy controlsGray matterCognitive impairmentMetabolic alterationsFrontal WMLC Model softwareProton magnetic resonance spectroscopic imagingFrontal white matter regionsCognitive biomarkersCholinergic neural transmissionPD-CN groupsMagnetic resonance spectroscopic imagingWhite matter regionsNeuro-metabolismPD dementiaFunctional impairmentPD-CIFunction lossNeural transmissionTotal creatineNormal cognitionTotal cholineDomain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment
Chaudhary S, Kumaran S, Kaloiya G, Goyal V, Sagar R, Kalaivani M, Jaganathan N, Mehta N, Srivastava A. Domain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment. Journal Of Clinical Neuroscience 2020, 75: 99-105. PMID: 32192853, DOI: 10.1016/j.jocn.2020.03.015.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentCognitive impairmentVisuospatial functionCognitive domain specificitySpecific cognitive impairmentsCognitive Assessment testMontreal Cognitive Assessment (MoCA) testStage of MCIExecutive functionPD clinical scoresDigit spanPD-MCIPD cognitionFronto-striatalRecall domainsDomain specificityCognitive AssessmentPD groupPotential confoundsCognitionCognitive pathophysiologyCortical syndromesCategorization of subjectsMemoryNormal cognition