2021
Preoperative evaluation of geriatric patients undergoing liver transplantation
Akhtar S. Preoperative evaluation of geriatric patients undergoing liver transplantation. Current Opinion In Anaesthesiology 2021, 35: 96-104. PMID: 34878418, DOI: 10.1097/aco.0000000000001084.Peer-Reviewed Original ResearchConceptsLiver transplantationNonalcoholic steatohepatitisGeriatric patientsElderly patientsPreoperative evaluationIncidence of NASHAge-related physiological changesPercent of patientsHepatitis C virusPortopulmonary hypertensionCirrhotic cardiomyopathyHepatopulmonary syndromeMultiple comorbiditiesPulmonary evaluationMetabolic syndromeFrailty evaluationPractice advisoryHepatocellular carcinomaPatientsTransplantationSyndromePhysiological changesHypertensionComorbiditiesSteatohepatitisNeurological Aging and Pharmacological Management of Geriatric Patients
Akhtar S. Neurological Aging and Pharmacological Management of Geriatric Patients. Current Anesthesiology Reports 2021, 11: 381-386. DOI: 10.1007/s40140-021-00497-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Pharmacological considerations in the elderly
Akhtar S. Pharmacological considerations in the elderly. Current Opinion In Anaesthesiology 2018, 31: 11-18. PMID: 29189287, DOI: 10.1097/aco.0000000000000544.Peer-Reviewed Original ResearchConceptsAnesthetic drugsNeurophysiological changesPoor perioperative outcomesCurrent practice patternsLarge database studiesDepth of anesthesiaIntraoperative hypotensionPerioperative outcomesElderly patientsAnesthetic medicationsDose adjustmentCNS depressionGeriatric patientsPractice patternsDrug managementPharmacologic studiesReceptor levelsPharmacological considerationsCurrent recommendationsDatabase studyElderly populationFunctional connectivityAnesthetic dosingHypotensionDrugs
2017
Cardiovascular System
Akhtar S, Ebert T. Cardiovascular System. 2017, 161-178. DOI: 10.1007/978-3-319-66878-9_11.ChaptersCardiovascular diseaseCardiovascular systemBest possible patient outcomesFrequency of dysrhythmiasPerioperative stress responseCoronary blood flowValvular heart diseaseAge-related disease processesPossible patient outcomesCardiac conduction systemAge-related changesElderly patientsCardiovascular reserveMyocardial dysfunctionDiastolic fillingCardiac functionHeart diseasePatient outcomesPathophysiological principlesCardiovascular stressHeart rateNeuroendocrine responsesAutonomic regulationBlood flowDisease process
2016
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Akhtar S, Heng J, Dai F, Schonberger RB, Burg MM. A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? Drugs & Aging 2016, 33: 737-746. PMID: 27581549, DOI: 10.1007/s40266-016-0394-x.Peer-Reviewed Original ResearchConceptsDoses of fentanylOlder patientsFemale patientsInduction dosesGeneral anesthesiaObservational studyTertiary care academic hospitalElderly surgical patientsIncidence of hypotensionDose of propofolRetrospective observational studyOld female patientIntravenous anesthetic agentPost-induction hypotensionAge-associated differencesQuality improvement effortsResultsOlder patientsVasopressor therapyElderly patientsSurgical patientsYounger patientsBlood pressureHemodynamic outcomesASA-PSStudy designWe
2015
Geriatric Pharmacology
Akhtar S, Ramani R. Geriatric Pharmacology. Anesthesiology Clinics 2015, 33: 457-469. PMID: 26315631, DOI: 10.1016/j.anclin.2015.05.004.Peer-Reviewed Original ResearchConceptsElderly patientsLong-term outcomesEnd-organ sensitivityFurther pharmacologic studiesOlder patientsAnesthetic medicationsGeriatric pharmacologyPharmacologic studiesAnesthetic drugsPatientsDrug overdosingDecreased volumePhysiologic processesContinuous variablesTrue extentMedicationsAnesthetics
2012
Vascular Surgery: Endovascular and Major Vascular Surgery
Akhtar S. Vascular Surgery: Endovascular and Major Vascular Surgery. 2012, 235-253. DOI: 10.1007/978-1-4614-3888-5_16.ChaptersElderly patientsVascular surgeryAdverse eventsPerioperative managementMajor vascular surgeryPerioperative adverse eventsComplex medical historyElderly patient presentingHigh-risk procedureNoncardiac surgerySignificant comorbiditiesCardiac eventsPreoperative evaluationPatient presentingMedical historyVascular proceduresSurgeryPatientsHealthy counterpartsSignificant proportionSame age cohortAge cohortsRiskComorbiditiesEndovascular
2010
Pain Management in Elderly Patients
Akhtar S, Rappa R, Ghori M. Pain Management in Elderly Patients. 2010, 699-713. DOI: 10.1007/978-0-387-87579-8_32.ChaptersPhysiologic changesNormal physiologic changesExtremes of ageNormal physiological changesProgressive physiological changesPhysiological changesChronological ageElderly patientsPhysiologic reservePain managementMedical conditionsNormal physiologyAgeCognitive changesInjuryBiological ageDiseaseBirth datePhysiological degenerationSame individualPhysiological processesPatientsDegenerationIndividuals